A Study to Evaluate the Safety and Efficacy of Upadacitinib in Participants With Giant Cell Arteritis
Public ClinicalTrials.gov record NCT03725202. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Upadacitinib in Subjects With Giant Cell Arteritis: SELECT-GCA
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study consists of two periods. The objective of Period 1 is to evaluate the efficacy of upadacitinib in combination with a 26-week corticosteroid (CS) taper regimen compared to placebo in combination with a 52-week CS taper regimen, as measured by the proportion of participants in sustained remission at Week 52, and to assess the safety and tolerability of upadacitinib in participants with giant cell arteritis (GCA). The objective of Period 2 is to evaluate the safety and efficacy of continuing versus withdrawing upadacitinib in maintaining remission in participants who achieved sustained remission in Period 1.
Study identification
- NCT ID
- NCT03725202
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 429 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 24, 2019 (Actual)
- Primary completion
- Feb 6, 2024 (Actual)
- Completion
- Mar 11, 2025 (Actual)
- Last update posted
- Feb 24, 2026
2019 – 2025
United States locations
- U.S. sites
- 53
- U.S. states
- 26
- U.S. cities
- 49
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Rheum Assoc of North Alabama /ID# 168668 | Huntsville | Alabama | 35801 | — |
| Arizona Arthritis and Rheumatology Research - Glendale Office /ID# 204702 | Glendale | Arizona | 85306-9802 | — |
| VA Long Beach Healthcare System /ID# 203833 | Long Beach | California | 90822-5201 | — |
| Robin K. Dore MD, Inc /ID# 201950 | Tustin | California | 92780 | — |
| Denver Arthritis Clinic /ID# 171552 | Denver | Colorado | 80230 | — |
| Duplicate_Western Connecticut Health Network- Germantown Rd /ID# 205071 | Danbury | Connecticut | 06810-5038 | — |
| Rheumatology Associates of South Florida (RASF) - Clinical Research /ID# 169040 | Boca Raton | Florida | 33486 | — |
| Lakes Research, LLC /ID# 210442 | Miami | Florida | 33014 | — |
| Ctr Arthritis & Rheumatic Dise /ID# 168667 | Miami | Florida | 33173 | — |
| Medallion Clinical Research Institute, LLC /ID# 168666 | Naples | Florida | 34102 | — |
| Omega Research Group /ID# 201903 | Orlando | Florida | 32808 | — |
| IRIS Research and Development, LLC /ID# 169406 | Plantation | Florida | 33324 | — |
| Clinical Research of West Florida - Tampa /ID# 201899 | Tampa | Florida | 33606-1246 | — |
| Clinical Research of West Florida, Inc /ID# 201901 | Tampa | Florida | 33606-1246 | — |
| Duplicate_University of South Florida /ID# 207077 | Tampa | Florida | 33612-2201 | — |
| Lovelace Scientific Resources /ID# 169041 | Venice | Florida | 34292 | — |
| Arthritis and Rheumatology /ID# 170295 | Atlanta | Georgia | 30342 | — |
| Institute of Arthritis Research /ID# 168490 | Idaho Falls | Idaho | 83404 | — |
| Duplicate_Rush University Medical Center /ID# 224581 | Chicago | Illinois | 60612 | — |
| Ochsner Clinic Foundation /ID# 200723 | Baton Rouge | Louisiana | 70836-6455 | — |
| The Arthritis & Diabetes Clinic, Inc. /ID# 171199 | Monroe | Louisiana | 71203 | — |
| Ochsner Clinic Foundation-New Orleans /ID# 171200 | New Orleans | Louisiana | 70121 | — |
| Louisiana State Univ HSC /ID# 202646 | Shreveport | Louisiana | 71130 | — |
| Rheumatology Associates PA - Portland /ID# 225011 | Portland | Maine | 04102-2643 | — |
| The Center for Rheumatology and Bone Research /ID# 168652 | Wheaton | Maryland | 20902 | — |
| University of Michigan Hospitals /ID# 168645 | Ann Arbor | Michigan | 48109-5008 | — |
| Wayne State University Health Center /ID# 212755 | Detroit | Michigan | 48201-2153 | — |
| Henry Ford Medical Center - New Center One /ID# 207456 | Detroit | Michigan | 48202-3046 | — |
| Duplicate_AA Medical Research Center - Grand Blanc /ID# 201854 | Grand Blanc | Michigan | 48439 | — |
| Duplicate_West Michigan Rheumatology /ID# 168647 | Grand Rapids | Michigan | 49546 | — |
| Clinvest Research LLC /ID# 208182 | Springfield | Missouri | 65807 | — |
| Physician Research Collaboration, LLC /ID# 168610 | Lincoln | Nebraska | 68516 | — |
| University Clinical Research Center /ID# 202504 | Somerset | New Jersey | 08873-3448 | — |
| University of Rochester Medical Center /ID# 213527 | Rochester | New York | 14642 | — |
| Marietta Memorial Hospital /ID# 210834 | Marietta | Ohio | 45750-1635 | — |
| STAT Research, Inc. /ID# 200436 | Vandalia | Ohio | 45377-9464 | — |
| University of Pennsylvania /ID# 168655 | Philadelphia | Pennsylvania | 19104-5502 | — |
| Piedmont Arthritis Clinic, PA /ID# 212431 | Greenville | South Carolina | 29601 | — |
| Articularis Healthcare Group, Inc d/b/a Low Country Rheumatology /ID# 212761 | Summerville | South Carolina | 29486-7887 | — |
| West Tennessee Research Institute /ID# 209256 | Jackson | Tennessee | 38305 | — |
| Arthritis Associates of Kingsport /ID# 212756 | Kingsport | Tennessee | 37660 | — |
| Allen Arthritis /ID# 225527 | Allen | Texas | 75013 | — |
| Tekton Research, L.L.C /ID# 201801 | Austin | Texas | 78745 | — |
| Precision Comprehensive Clinical Research Solutions /ID# 201798 | Colleyville | Texas | 76034 | — |
| West Texas Clinical Research /ID# 204834 | Lubbock | Texas | 79424 | — |
| Arthritis and Rheumatology Institute, PLLC /ID# 214612 | Plano | Texas | 75093-6419 | — |
| Baylor Scott & White Center for Diagnostic Medicine /ID# 213529 | Temple | Texas | 76508 | — |
| University of Vermont Medical Center /ID# 211179 | Burlington | Vermont | 05401-1473 | — |
| Carilion Clinic /ID# 212928 | Roanoke | Virginia | 24016 | — |
| Kadlec Clinic Rheumatology /ID# 201618 | Kennewick | Washington | 99336 | — |
| University of Washington /ID# 201619 | Seattle | Washington | 98109 | — |
| Aurora Rheumatology and Immunotherapy Center /ID# 201853 | Franklin | Wisconsin | 53132 | — |
| Froedtert Memorial Lutheran Hospital /ID# 224557 | Milwaukee | Wisconsin | 53226-3522 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 119 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03725202, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 24, 2026 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03725202 live on ClinicalTrials.gov.