A Study to Compare Safety and Efficacy of Upadacitinib to Dupilumab in Adult Participants With Moderate to Severe Atopic Dermatitis
Public ClinicalTrials.gov record NCT03738397. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3b Multicenter, Randomized, Double-Blind, Double-Dummy, Active Controlled Study Comparing the Safety and Efficacy of Upadacitinib to Dupilumab in Adult Subjects With Moderate to Severe Atopic Dermatitis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate upadacitinib compared to dupilumab (Dupixent®) in adults with moderate to severe atopic dermatitis (AD) who are candidates for systemic therapy.
Study identification
- NCT ID
- NCT03738397
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 673 participants
Conditions and interventions
Conditions
Interventions
- Upadacitinib Biological
- Dupilumab Biological
- Placebo to dupilumab Drug
- Placebo to upadacitinib Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years to 76 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 21, 2019 (Actual)
- Primary completion
- Aug 27, 2020 (Actual)
- Completion
- Dec 9, 2020 (Actual)
- Last update posted
- Mar 15, 2024
2019 – 2020
United States locations
- U.S. sites
- 52
- U.S. states
- 24
- U.S. cities
- 46
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clinical Research Center AL /ID# 210277 | Birmingham | Alabama | 35209-6802 | — |
| University of Arkansas for Medical Sciences /ID# 211688 | Little Rock | Arkansas | 72205 | — |
| Tien Q Nguyen MD, Inc /ID# 208934 | Fountain Valley | California | 92708-3701 | — |
| UCSF Fresno /ID# 213253 | Fresno | California | 93701-2302 | — |
| Jonathan Corren, MD. INC /ID# 208987 | Los Angeles | California | 90025-4749 | — |
| California Allergy and Asthma Medical Group /ID# 213680 | Los Angeles | California | 90025-7014 | — |
| Dermatology Research Associates /ID# 209097 | Los Angeles | California | 90045 | — |
| Los Angelos Cataract Center /ID# 208524 | Los Angeles | California | 90056 | — |
| Dermatology Clinical Trials /ID# 214622 | Newport Beach | California | 92660-7853 | — |
| UC Davis Health /ID# 209285 | Sacramento | California | 95816 | — |
| Ucsd /Id# 208990 | San Diego | California | 92103 | — |
| Clinical Science Institute /ID# 211022 | Santa Monica | California | 90404-2102 | — |
| The Community Research of South Florida /ID# 211145 | Hialeah | Florida | 33016-1897 | — |
| Miami Dermatology and Laser Institute /ID# 212938 | Miami | Florida | 33173-3570 | — |
| Florida International Rsrch cr /ID# 211562 | Miami | Florida | 33173 | — |
| Progressive Medical Research /ID# 211994 | Port Orange | Florida | 32127 | — |
| GCP Research /ID# 216020 | St. Petersburg | Florida | 33705 | — |
| Clinical Research Trials of Florida, Inc. /ID# 210751 | Tampa | Florida | 33607 | — |
| Integrated Clinical Research LLC /ID# 208831 | West Palm Beach | Florida | 33406-6063 | — |
| Georgia Pollens Clinical Research Centers, Inc /ID# 211092 | Albany | Georgia | 31707-1282 | — |
| Meridian Clinical Research Dermatology /ID# 213251 | Savannah | Georgia | 31406-2632 | — |
| Northwestern University Feinberg School of Medicine /ID# 208680 | Chicago | Illinois | 60611-2927 | — |
| Medical Dermatology Associates of Chicago /ID# 210265 | Chicago | Illinois | 60654-6903 | — |
| Sneeze, Wheeze, & Itch Associates, LLC /ID# 212058 | Normal | Illinois | 61761 | — |
| Dawes Fretzin, LLC /ID# 209187 | Indianapolis | Indiana | 46256 | — |
| Beacon Clinical Research, LLC /ID# 209280 | Quincy | Massachusetts | 02169 | — |
| Clarkston Skin Research /ID# 208739 | Clarkston | Michigan | 48346 | — |
| Henry Ford Health System /ID# 208741 | Detroit | Michigan | 48202 | — |
| Clinical Research Institute, Inc /ID# 210852 | Minneapolis | Minnesota | 55402-2606 | — |
| Allergy, Asthma & Immunology Associates, PC /ID# 213481 | Lincoln | Nebraska | 68505-2343 | — |
| Skin Specialists, PC /ID# 208843 | Omaha | Nebraska | 68144 | — |
| Dartmouth-Hitchcock Medical Center /ID# 213727 | Lebanon | New Hampshire | 03756 | — |
| Forest Hills Dermatology Group /ID# 209249 | Kew Gardens | New York | 11415 | — |
| Montefiore Medical Center /ID# 209647 | The Bronx | New York | 10467 | — |
| Wake Forest Univ HS /ID# 208892 | Winston-Salem | North Carolina | 27157 | — |
| Univ Hosp Cleveland /ID# 208852 | Cleveland | Ohio | 44106 | — |
| The Ohio State University /ID# 209254 | Columbus | Ohio | 43210-1257 | — |
| Southside Dermatology /ID# 212004 | Tulsa | Oklahoma | 74132 | — |
| Oregon Medical Res Center PC /ID# 208807 | Portland | Oregon | 97223 | — |
| Oregon Health and Science University /ID# 208809 | Portland | Oregon | 97239 | — |
| Medical University of South Carolina /ID# 211054 | Charleston | South Carolina | 29425 | — |
| Clinical Research Solutions, LLC /ID# 212542 | Jackson | Tennessee | 38305-2163 | — |
| Orion Clinical Research /ID# 208765 | Austin | Texas | 78759-4100 | — |
| DiscoveResearch, Inc. /ID# 213171 | Bryan | Texas | 77802 | — |
| Epiphany Dermatology - Fort Worth /ID# 211187 | Fort Worth | Texas | 76244-6548 | — |
| Sante Clinical Research /ID# 212970 | Kerrville | Texas | 78028-9640 | — |
| Stephen Miller, MD PA /ID# 210071 | San Antonio | Texas | 78249 | — |
| Sugar Land Allergy, Asthma, and Immunology Center /ID# 211153 | Sugar Land | Texas | 77479-3153 | — |
| University of Utah /ID# 209001 | Salt Lake City | Utah | 84112-5500 | — |
| Clinical Research Partners, LLC /ID# 212262 | Richmond | Virginia | 23220-4459 | — |
| Premier Clinical Research /ID# 212142 | Spokane | Washington | 99202 | — |
| West Virginia Research Inst /ID# 212730 | South Charleston | West Virginia | 25309 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 107 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03738397, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 15, 2024 · Synced Oct 16, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03738397 live on ClinicalTrials.gov.