Brain Oxygen Optimization in Severe TBI, Phase 3
Public ClinicalTrials.gov record NCT03754114. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Brain Oxygen Optimization in Severe TBI (BOOST3): A Comparative Effectiveness Study to Test the Efficacy of a Prescribed Treatment Protocol Based on Monitoring the Partial Pressure of Brain Tissue Oxygen.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
BOOST3 is a randomized clinical trial to determine the comparative effectiveness of two strategies for monitoring and treating patients with traumatic brain injury (TBI) in the intensive care unit (ICU). The study will determine the safety and efficacy of a strategy guided by treatment goals based on both intracranial pressure (ICP) and brain tissue oxygen (PbtO2) as compared to a strategy guided by treatment goals based on ICP monitoring alone. Both of these alternative strategies are used in standard care. It is unknown if one is more effective than the other. In both strategies the monitoring and goals help doctors adjust treatments including the kinds and doses of medications and the amount of intravenous fluids given, ventilator (breathing machine) settings, need for blood transfusions, and other medical care. The results of this study will help doctors discover if one of these methods is more safe and effective.
Study identification
- NCT ID
- NCT03754114
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 1,094 participants
Conditions and interventions
Conditions
Interventions
Other
Eligibility (public fields only)
- Age range
- 14 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 28, 2019 (Actual)
- Primary completion
- Nov 1, 2027 (Estimated)
- Completion
- Nov 1, 2027 (Estimated)
- Last update posted
- May 5, 2026
2019 – 2027
United States locations
- U.S. sites
- 48
- U.S. states
- 26
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Ronald Reagan UCLA Medical Center | Los Angeles | California | 90095-7436 | — |
| Stanford University Medical Center | Palo Alto | California | 94305 | — |
| UC Davis Medical Center | Sacramento | California | 95817 | — |
| San Francisco General Hospital | San Francisco | California | 94143 | — |
| University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| Yale New Haven Hospital | New Haven | Connecticut | 06510 | — |
| UF Health Shands Hospital | Gainesville | Florida | 32608 | — |
| Grady Memorial Hospital | Atlanta | Georgia | 30303 | — |
| The Queen's Medical Center | Honolulu | Hawaii | 96813 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| St. Vincent Hospital | Indianapolis | Indiana | 46260 | — |
| Maine Medical Center | Portland | Maine | 04102 | — |
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02128 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| UMASS Memorial Medical Center | Worcester | Massachusetts | 01655 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Detroit Receiving Hospital | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital | Detroit | Michigan | 48201 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| Cooper University Hospital | Camden | New Jersey | 08103 | — |
| University of New Mexico Hospital | Albuquerque | New Mexico | 87131 | — |
| NewYork-Presbyterian Queens Hospital | Flushing | New York | 11355 | — |
| North Shore University Hospital | Manhasset | New York | 11030 | — |
| NYP Columbia University Medical Center | New York | New York | 10032 | — |
| Strong Memorial Hospital | Rochester | New York | 14642 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| Jacobi Medical Center | The Bronx | New York | 10461 | — |
| University of North Carolina Medical Center | Chapel Hill | North Carolina | 27514 | — |
| Duke University Hospital | Durham | North Carolina | 27710 | — |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45219 | — |
| OSU Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Oregon Health & Science University Hospital | Portland | Oregon | 97239 | — |
| Penn Presbyterian Medical Center | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| UPMC Presbyterian Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Parkland Hospital | Dallas | Texas | 75235 | — |
| Ben Taub General Hospital | Houston | Texas | 77030 | — |
| University of Texas Health Science Center San Antonio | San Antonio | Texas | 78229 | — |
| University of Utah Healthcare | Salt Lake City | Utah | 84132 | — |
| VCU Medical Center | Richmond | Virginia | 23298 | — |
| Harborview Medical Center | Seattle | Washington | 98104 | — |
| WVU Healthcare Ruby Memorial Hospital | Morgantown | West Virginia | 26506 | — |
| Froedtert Hospital | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03754114, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 5, 2026 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03754114 live on ClinicalTrials.gov.