A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy
Public ClinicalTrials.gov record NCT03767244. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of Apalutamide in Subjects With High-risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to determine if treatment with apalutamide plus androgen deprivation therapy (ADT) before and after radical prostatectomy (RP) with pelvic lymph node dissection (pLND) in participants with high-risk localized or locally advanced prostate cancer results in an improvement in pathological complete response (pCR) rate and metastasis-free survival (MFS) as compared to placebo plus ADT.
Study identification
- NCT ID
- NCT03767244
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2,517 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 11, 2019 (Actual)
- Primary completion
- Dec 1, 2026 (Estimated)
- Completion
- Oct 13, 2028 (Estimated)
- Last update posted
- Sep 25, 2026
2019 – 2028
United States locations
- U.S. sites
- 44
- U.S. states
- 22
- U.S. cities
- 39
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| University of Southern California | Los Angeles | California | 90033 | — |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | — |
| University of California Los Angeles | Los Angeles | California | 90095 | — |
| University of California Irvine Medical Center Chao Family Comprehensive Cancer Center | Orange | California | 92868 | — |
| UC Davis Medical Center | Sacramento | California | 95817 | — |
| AdventHealth Medical Group Urology of Denver | Denver | Colorado | 80210 | — |
| Colorado Clinical Research | Lakewood | Colorado | 80228 | — |
| Stamford Hospital | Stamford | Connecticut | 06904 | — |
| Urology Specialists LLC | Hialeah | Florida | 33002 | — |
| Mayo Clinic - Division Of Hematology/oncology | Jacksonville | Florida | 32224 | — |
| Miami Cancer Institute at Baptist Health / Baptist Health Medical Group | Miami | Florida | 33176 | — |
| Advent Health | Orlando | Florida | 32804 | — |
| Emory University Winship Cancer Institute | Atlanta | Georgia | 30322-1013 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Ochsner LSU Health Shreveport - Regional Urology | Shreveport | Louisiana | 71106 | — |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02115 | — |
| Beth Isreal Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Michigan Institute of Urology, PC | Troy | Michigan | 48084 | — |
| Saint Louis University | St Louis | Missouri | 63110 | — |
| Urology Cancer Center, PC | Omaha | Nebraska | 68130 | — |
| Albany Medical College | Albany | New York | 12208 | — |
| Great Lakes Physician PC d/b/a Western New York Urology Associates | Cheektowaga | New York | 14225 | — |
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10065 | — |
| Weill Cornell Medical College | New York | New York | 10065 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27599 | — |
| Duke University School of Medicine | Durham | North Carolina | 27705 | — |
| Medication Management LLC | Greensboro | North Carolina | 27403 | — |
| Carolina Urology Partners, PLLC | Huntersville | North Carolina | 28078 | — |
| Cleveland VA Medical Center | Cleveland | Ohio | 44106 | — |
| Oklahoma City VAMC | Oklahoma City | Oklahoma | 73104 | — |
| MidLantic Urology | Bala-Cynwyd | Pennsylvania | 19004 | — |
| Omega Medical Research | Warwick | Rhode Island | 02886 | — |
| Ralph H. Johnson Veterans Affairs Medical Center | Charleston | South Carolina | 29401 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29403 | — |
| Greenville Health | Greenville | South Carolina | 29605 | — |
| Carolina Urologic Research Center | Myrtle Beach | South Carolina | 29572 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| VA North Texas Health Care System | Dallas | Texas | 75216 | — |
| MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Virginia Urology | Richmond | Virginia | 23235 | — |
| Urology of Virginia, PLCC | Virginia Beach | Virginia | 23462 | — |
| CAMC Memorial Hospital, Charleston Area Medical Center Physicians | Charleston | West Virginia | 25304 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 159 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03767244, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 25, 2026 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03767244 live on ClinicalTrials.gov.