Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE)
Public ClinicalTrials.gov record NCT03767348. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-Label, Multicenter, Phase 1/2 Study of RP1 as a Single Agent and in Combination With PD1 Blockade in Patients With Solid Tumors [IGNYTE]
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The Phase 2 study is a multicenter, open-label study of RP1 to further investigate safety and to estimate the efficacy of RP1 at the RP2D in combination with nivolumab in patients with Stage IIIb-IV unresectable melanoma, microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) solid tumors, non-melanoma skin cancer (NMSC), and non-small cell lung cancer (NSCLC).
Study identification
- NCT ID
- NCT03767348
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 340 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 20, 2017 (Actual)
- Primary completion
- Jun 2028 (Estimated)
- Completion
- Dec 2028 (Estimated)
- Last update posted
- Feb 13, 2026
2017 – 2028
United States locations
- U.S. sites
- 26
- U.S. states
- 18
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Birmingham Alabama | Birmingham | Alabama | 35294 | — |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | — |
| Mayo Clinic | Phoenix | Arizona | 85054 | — |
| Carti Cancer Center | Little Rock | Arkansas | 72205 | — |
| UC San Diego | La Jolla | California | 92093 | — |
| University of Southern California | Los Angeles | California | 90033 | — |
| UCLA | Los Angeles | California | 90095 | — |
| University of California, Irvine | Orange | California | 92868 | — |
| University of California- San Francisco | San Francisco | California | 94115 | — |
| Sylvester Comprehensive Cancer Center- University of Miami | Miami | Florida | 33136 | — |
| University of Iowa-Cancer Center Research | Iowa City | Iowa | 52242 | — |
| James Graham Brown Cancer Center- University of Louisville | Louisville | Kentucky | 40202 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| New York University Clinical Cancer Center | New York | New York | 10016 | — |
| Weill Cornell Medical College | New York | New York | 10065 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Duke Cancer Center | Durham | North Carolina | 27710 | — |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45267 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| MUSC Health | Charleston | South Carolina | 29425 | — |
| West Cancer Center | Germantown | Tennessee | 38138 | — |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Eccles Outpatient Care Center- Oncology Clinical Trials | Murray | Utah | 84107 | — |
| Intermountain Cancer Center- Saint George Cancer Center | St. George | Utah | 84790 | — |
| Seattle Cancer Care Alliance- University of Washington | Seattle | Washington | 98109 | — |
| University of Wisconsin-Carbone Cancer Center | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 25 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03767348, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 13, 2026 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03767348 live on ClinicalTrials.gov.