Evaluation of Lasofoxifene Versus Fulvestrant in Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation
Public ClinicalTrials.gov record NCT03781063. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-Label, Randomized, Multicenter Study Evaluating the Activity of Lasofoxifene Relative to Fulvestrant for the Treatment of Pre- and Postmenopausal Women With Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation
Study identification
- NCT ID
- NCT03781063
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Sermonix Pharmaceuticals Inc.
- Industry
- Enrollment
- 100 participants
Conditions and interventions
Conditions
Interventions
- Fulvestrant Drug
- Lasofoxifene Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 19, 2019
- Primary completion
- May 7, 2025
- Completion
- May 7, 2025
- Last update posted
- Jan 27, 2026
2019 – 2025
United States locations
- U.S. sites
- 42
- U.S. states
- 24
- U.S. cities
- 39
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Arizona | Phoenix | Arizona | 85054 | — |
| Yuma Regional Medical Center (JIT) | Yuma | Arizona | 85364 | — |
| City of Hope Comprehensive Cancer | Duarte | California | 91010 | — |
| Compassionate Care Research Group | Fountain Valley | California | 92708 | — |
| UCSF Cancer Center | San Francisco | California | 94115 | — |
| Rocky Mountain Cancer Centers | Longmont | Colorado | 80501 | — |
| Mayo Clinic Florida | Jacksonville | Florida | 32224 | — |
| Miami Cancer Institute | Miami | Florida | 33176 | — |
| Ocala Oncology Center (JIT) | Oscala | Florida | 34474 | — |
| Florida Cancer Specialists | Tallahassee | Florida | 32308 | — |
| The Bond Clinic Cancer & Research Center. | Winter Haven | Florida | 33880 | — |
| Emory University | Atlanta | Georgia | 30322 | — |
| Hawaii Cancer Care (JIT) | Honolulu | Hawaii | 96813 | — |
| Robert H. Lurie Comprehensive Cancer Center of Northwestern University | Chicago | Illinois | 60611 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Illinois Cancer Care (JIT) | Peoria | Illinois | 61615 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Beacon Health (JIT) | South Bend | Indiana | 46601 | — |
| University of Louisville / James Graham Brown Cancer Center | Louisville | Kentucky | 40202 | — |
| FMH James M Stockman Cancer Institute (JIT) | Frederick | Maryland | 21702 | — |
| Mayo Clinic | Rochester | Minnesota | 55902 | — |
| Hattiesburg Clinic Hematology/Oncology | Hattiesburg | Mississippi | 39401 | — |
| Saint Luke's Cancer Institute | Kansas City | Missouri | 64111 | — |
| HCA Midwest Health | Kansas City | Missouri | 64132 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Comprehensive Cancer Centers of Nevada (JIT) | Las Vegas | Nevada | 89128 | — |
| New Jersey Cancer Care and Blood Disorders (JIT) | Belleville | New Jersey | 07203 | — |
| Summit Medical Group (JIT) | Florham Park | New Jersey | 07932 | — |
| Roswell Park Comprehensive Cancer Center | Buffalo | New York | 14263 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| TriHealth Cancer Institute | Cincinnati | Ohio | 45220 | — |
| The Ohio State University - Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| Ohio Health (JIT) | Columbus | Ohio | 43221 | — |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| Sanford Cancer Center (JIT) | Sioux Falls | South Dakota | 57104 | — |
| Tennessee Oncology Chattanooga | Chattanooga | Tennessee | 37404 | — |
| West Cancer Center | Germantown | Tennessee | 38138 | — |
| Tennessee Oncology/SCRI | Nashville | Tennessee | 37203 | — |
| Mary Crowley Cancer Research (JIT) | Dallas | Texas | 75230 | — |
| Oncology Consultants (JIT) | Houston | Texas | 77024 | — |
| Utah Cancer Specialists (JIT) | Salt Lake City | Utah | 84102 | — |
| Peninsula Cancer Institute | Newport News | Virginia | 23601 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 9 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03781063, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 27, 2026 · Synced May 4, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03781063 live on ClinicalTrials.gov.