A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
Public ClinicalTrials.gov record NCT03811561. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Long-term Effects of Semaglutide on Diabetic Retinopathy in Subjects With Type 2 Diabetes
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will look at the long-term effects of semaglutide (active medicine) on diabetic eye disease when compared to placebo (dummy medicine). The study will be performed in people with type 2 diabetes. Participants will either get semaglutide or placebo in addition to their diabetes medicines - which treatment the participant gets is decided by chance. Participants will inject the study medicine using a pen-injector. The medicine must be injected in a skin fold in the stomach, thigh or upper arm once a week. The study will last for 5 years.
Study identification
- NCT ID
- NCT03811561
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,500 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 8, 2019 (Actual)
- Primary completion
- Nov 7, 2027 (Estimated)
- Completion
- Nov 7, 2027 (Estimated)
- Last update posted
- Oct 7, 2026
2019 – 2027
United States locations
- U.S. sites
- 72
- U.S. states
- 27
- U.S. cities
- 57
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Synexus Rsch /Cnt Phnx Med C | Phoenix | Arizona | 85050 | — |
| Del Sol Research Management, LLC | Tucson | Arizona | 85715 | — |
| South Arizona VA Healthcare System | Tucson | Arizona | 85723 | — |
| Synexus Cln Rsrch Inc - Orange Gro FP | Tucson | Arizona | 85741 | — |
| Southern California Res Ctr | Coronado | California | 92118 | — |
| FDRC | Costa Mesa | California | 92627 | — |
| Advanced Investigative Medicine, Inc. | Hawthorne | California | 90250 | — |
| Diabetes/Lipid Mgmt & Res Ctr | Huntington Beach | California | 92648 | — |
| Scripps Whittier Diabetes Inst | La Jolla | California | 92037 | — |
| Torrance Clin Res Inst, Inc. | Lomita | California | 90717 | — |
| Angel City Research, Inc. | Los Angeles | California | 90010 | — |
| Downtown LA Res Ctr. Inc. | Los Angeles | California | 90017 | — |
| Riverside University Health System Medical Center | Moreno Valley | California | 92555 | — |
| Rancho Cucamonga Clinical Research | Rancho Cucamonga | California | 91730-3063 | — |
| Clinical Trials Research_Sacramento_0 | Sacramento | California | 95821 | — |
| UCLA Diabetes Center at Santa Monica | Santa Monica | California | 90404 | — |
| Coastal Metabolic Research Center | Ventura | California | 93003 | — |
| Diablo Clinical Research, Inc. | Walnut Creek | California | 94598 | — |
| Barbara Davis Center | Aurora | Colorado | 80045 | — |
| Rocky Mount Reg VA Med-DN | Aurora | Colorado | 80045 | — |
| Chase Medical Research LLC | Waterbury | Connecticut | 06708 | — |
| Innovative Research of W FL | Clearwater | Florida | 33756 | — |
| Est Cst Inst for Rsrch,Jksnvil | Jacksonville | Florida | 32216 | — |
| Reyes Clinical Research, Inc | Miami | Florida | 33175 | — |
| Renstar Medical Research | Ocala | Florida | 34471 | — |
| Atlanta Diabetes Associates | Atlanta | Georgia | 30318 | — |
| Endo Res Solutions Inc | Roswell | Georgia | 30076 | — |
| Apex Medical Research Inc | Chicago | Illinois | 60607 | — |
| The University Of Chicago | Chicago | Illinois | 60637 | — |
| American Health Network of Indiana, LLC_Avon | Avon | Indiana | 46123 | — |
| American Health Network of Indiana, LLC_Greenfield | Greenfield | Indiana | 46140 | — |
| Iowa Diab & Endo Res Center | West Des Moines | Iowa | 50266 | — |
| VA Medical Center | Lexington | Kentucky | 40502 | — |
| Kentucky Diabetes-Endocrinology Center | Lexington | Kentucky | 40503 | — |
| The Research Group of Lexington LLC | Lexington | Kentucky | 40503 | — |
| L-MARC Research Center | Louisville | Kentucky | 40213 | — |
| Four Rivers Clinical Research Inc | Paducah | Kentucky | 42001 | — |
| MedStar Hlth Res Institute | Hyattsville | Maryland | 20782 | — |
| Brigham & Women's Hospital | Boston | Massachusetts | 02115 | — |
| Boston Medical Center_Cary | Boston | Massachusetts | 02118 | — |
| Joslin Center For Diabetes | Boston | Massachusetts | 02215 | — |
| Joslin Diabetes Center | Boston | Massachusetts | 02215 | — |
| Michigan Medicine | Ann Arbor | Michigan | 48105 | — |
| Synexus Clinical Research US, Inc._Tempe_0 | Richfield | Minnesota | 55432 | — |
| Diabetes & Endo Specialists Inc | Chesterfield | Missouri | 63017 | — |
| Palm Research Center Inc-Vegas | Las Vegas | Nevada | 89148 | — |
| Southern New Hampshire Diabete | Nashua | New Hampshire | 03060 | — |
| Lovelace Scientific Resources Inc | Albuquerque | New Mexico | 87108 | — |
| University of New Mexico | Albuquerque | New Mexico | 87131 | — |
| NYC Research, Inc. | New York | New York | 10016 | — |
| Mountain Diabetes & Endocrine Center | Asheville | North Carolina | 28803 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27514 | — |
| OnSite Clinical Solutions, LLC | Charlotte | North Carolina | 28226 | — |
| Your Diabetes Endocrine Nutrition Group, Inc. | Mentor | Ohio | 44060 | — |
| University of Toledo Medical Center | Toledo | Ohio | 43614 | — |
| Harold Hamm Diabetes Center | Oklahoma City | Oklahoma | 73104 | — |
| Aria Endocrine Metabolic Assoc | Philadelphia | Pennsylvania | 19114 | — |
| Tristar Clin Investigations, PC | Philadelphia | Pennsylvania | 19114 | — |
| Holston Medical Group Pc | Bristol | Tennessee | 37620-7352 | — |
| Univ Diab & Endo Consultants | Chattanooga | Tennessee | 37411 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| Vanderbilt Diab Obes Clin Tri | Nashville | Tennessee | 37212 | — |
| Central Texas Clinical Research | Austin | Texas | 78705 | — |
| Texas Diab & Endo, P.A. | Austin | Texas | 78731 | — |
| Velocity Clinical Res-Dallas | Dallas | Texas | 75230 | — |
| UT Southwestern Med Cntr | Dallas | Texas | 75390-9302 | — |
| Clinical Trials of Texas, LLC | San Antonio | Texas | 78229 | — |
| VIP Trials | San Antonio | Texas | 78230 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| Simcare Medical Research, LLC | Sugar Land | Texas | 77478 | — |
| Synexus Clinical Research US, INC. | Murray | Utah | 84107 | — |
| MultiCare Inst for Res & Innov | Spokane | Washington | 99202 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 158 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03811561, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 7, 2026 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03811561 live on ClinicalTrials.gov.