A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (LUCERNE)
Public ClinicalTrials.gov record NCT03823300. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Multicenter, Randomized, Double-Masked, Active Comparator-Controlled Study to Evaluate the Efficacy and Safety of Faricimab in Patients With Neovascular Age-Related Macular Degeneration (LUCERNE)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate the efficacy, safety, durability, and pharmacokinetics of faricimab administered at intervals as specified in the protocol, compared with aflibercept once every 8 weeks (Q8W), in participants with neovascular age-related macular degeneration (nAMD).
Study identification
- NCT ID
- NCT03823300
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 658 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 11, 2019 (Actual)
- Primary completion
- Oct 5, 2020 (Actual)
- Completion
- Jan 7, 2022 (Actual)
- Last update posted
- Jul 11, 2025
2019 – 2022
United States locations
- U.S. sites
- 41
- U.S. states
- 22
- U.S. cities
- 39
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Associated Retina Consultants | Phoenix | Arizona | 85020 | — |
| Arizona Retina and Vitreous Consultants | Phoenix | Arizona | 85021 | — |
| Northern California Retina Vitreous Associates | Mountain View | California | 94040 | — |
| Retinal Consultants Med Group | Sacramento | California | 95825 | — |
| Orange County Retina Med Group | Santa Ana | California | 92705 | — |
| California Retina Consultants | Santa Barbara | California | 93103 | — |
| Colorado Retina Associates, PC | Golden | Colorado | 80401 | — |
| Retina Group of Florida | Fort Lauderdale | Florida | 33308 | — |
| Retina Care Specialists | Palm Beach Gardens | Florida | 33410 | — |
| Southern Vitreoretinal Assoc | Tallahassee | Florida | 32308 | — |
| Retina Associates of Florida, LLC | Tampa | Florida | 33609 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| Georgia Retina PC | Marietta | Georgia | 30060 | — |
| Retina Consultants of Hawaii | ‘Aiea | Hawaii | 96701 | — |
| University Retina and Macula Associates, PC | Oak Forest | Illinois | 60452 | — |
| Prairie Retina Center | Springfield | Illinois | 62704 | — |
| Raj K. Maturi, MD PC | Indianapolis | Indiana | 46290 | — |
| Wolfe Eye Clinic | West Des Moines | Iowa | 50266 | — |
| Maine Eye Center | Portland | Maine | 04101 | — |
| The Retina Care Center | Baltimore | Maryland | 21209 | — |
| Cumberland Valley Retina PC | Hagerstown | Maryland | 21740 | — |
| Retina Specialists | Towson | Maryland | 21204 | — |
| Ophthalmic Consultants of Boston | Boston | Massachusetts | 02114 | — |
| VitreoRetinal Surgery, PLLC. | Minneapolis | Minnesota | 55435 | — |
| Mid Atlantic Retina - Wills Eye Hospital | Cherry Hill | New Jersey | 08034 | — |
| Island Retina | Shirley | New York | 11967 | — |
| Retina Assoc of Cleveland Inc | Cleveland | Ohio | 44122 | — |
| The Ohio State University Havener Eye Institute | Columbus | Ohio | 43212 | — |
| Midwest Retina | Dublin | Ohio | 43016 | — |
| Palmetto Retina Center | West Columbia | South Carolina | 29169 | — |
| Southeastern Retina Associates Chattanooga | Chattanooga | Tennessee | 37421 | — |
| Retina Res Institute of Texas | Abilene | Texas | 79606 | — |
| Austin Retina Associates | Austin | Texas | 78705 | — |
| Austin Clinical Research LLC | Austin | Texas | 78750 | — |
| Retina Center of Texas | Grapevine | Texas | 76051 | — |
| Retina Consultants of Houston | The Woodlands | Texas | 77384 | — |
| Strategic Clinical Research Group, LLC | Willow Park | Texas | 76087 | — |
| Retina Associates of Utah, PLLC | Murray | Utah | 84107 | — |
| Piedmont Eye Center | Lynchburg | Virginia | 24502 | — |
| Wagner Kapoor Institute | Norfolk | Virginia | 23502 | — |
| Pacific Northwest Retina | Silverdale | Washington | 98383 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 96 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03823300, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 11, 2025 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03823300 live on ClinicalTrials.gov.