ClinicalTrials.gov record
A Phase 3 Study to Evaluate the Efficacy and Safety of MGL-3196 (Resmetirom) in Patients With NASH and Fibrosis
ClinicalTrials.gov ID: NCT03900429
Public ClinicalTrials.gov record NCT03900429. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multinational, Double-Blind, Randomized, Placebo-Controlled Study of MGL-3196 (Resmetirom) in Patients With Non-Alcoholic Steatohepatitis (NASH) and Fibrosis to Resolve NASH and Reduce Progression to Cirrhosis and/or Hepatic Decompensation
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A double-blind placebo controlled randomized Phase 3 study to determine if 80 or 100 mg of MGL-3196 as compared with placebo resolves NASH and/or reduces fibrosis on liver biopsy and prevents progression to cirrhosis and/or advanced liver disease
Study identification
- NCT ID
- NCT03900429
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,759 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 28, 2019 (Actual)
- Primary completion
- Jan 2028 (Estimated)
- Completion
- Jan 2028 (Estimated)
- Last update posted
- Jun 1, 2026
2019 – 2028
United States locations
- U.S. sites
- 90
- U.S. states
- 23
- U.S. cities
- 72
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35249 | — |
| East Valley Family Physicians | Chandler | Arizona | 85224 | — |
| The Institute for Liver Health - Chandler | Chandler | Arizona | 85224 | — |
| The Institute for Liver Health - Glendale | Glendale | Arizona | 85306 | — |
| Desert Clinical Research | Mesa | Arizona | 85213 | — |
| Adobe Gastroenterology | Tucson | Arizona | 85712 | — |
| The Institute for Liver Health - Tucson | Tucson | Arizona | 85712 | — |
| Arkansas Gastroenterology | North Little Rock | Arkansas | 72117 | — |
| Fresno Clinical Research Center | Fresno | California | 93720 | — |
| National Research Institute - Huntington Park | Huntington Park | California | 90255 | — |
| University of California San Diego | La Jolla | California | 92037 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| National Research Institute - Los Angeles | Los Angeles | California | 90057 | — |
| Ruane Clinical Research | Los Angeles | California | 90057 | — |
| Stanford University School of Medicine | Palo Alto | California | 94304 | — |
| National Research Institute - Panorama City | Panorama City | California | 91402 | — |
| Alliance Clinical Research | Poway | California | 92064 | — |
| San Fernando Valley Health Institute | Van Nuys | California | 91405 | — |
| Colorado Springs Family Practice | Colorado Springs | Colorado | 80909 | — |
| South Denver Gastroenterology - Swedish Medical Center Office | Englewood | Colorado | 80113 | — |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | — |
| Covenant Metabolic Specialists - Fort Myers | Fort Myers | Florida | 33912 | — |
| University of Florida Hepatology Research at CTRB | Gainesville | Florida | 32610 | — |
| Nature Coast Clinical Research | Inverness | Florida | 34452 | — |
| Florida Research Institute | Lakewood Rch | Florida | 34211 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Miami Dade Medical Research Institute | Miami | Florida | 33176 | — |
| Bioclinica Research - Orlando | Orlando | Florida | 32806 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Covenant Research | Sarasota | Florida | 34240 | — |
| Bioclinica Research - The Villages | The Villages | Florida | 32162 | — |
| GI Specialists of Georgia | Marietta | Georgia | 30060 | — |
| Clinical Research - Chicago | Chicago | Illinois | 60602 | — |
| Northwestern Medical Faculty Foundation | Chicago | Illinois | 60611 | — |
| The University of Chicago Medicine | Chicago | Illinois | 60637 | — |
| University of Kansas Medical Center Research Institute | Fairway | Kansas | 66205 | — |
| Kansas Medical Clinic - Gastroenterology | Topeka | Kansas | 66606 | — |
| Texas Digestive Disease Consultants - Gastroenterology Associates - Baton Rouge | Baton Rouge | Louisiana | 70809 | — |
| Tandem Clinical Research | Marrero | Louisiana | 70072 | — |
| Tulane University School of Medicine | New Orleans | Louisiana | 70112 | — |
| Ochsner Medical Center | New Orleans | Louisiana | 70121 | — |
| Clinical Trials of America | West Monroe | Louisiana | 71291 | — |
| Walter Reed National Military Medical Center | Bethesda | Maryland | 20889 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Gastrointestinal Associates and Endoscopy Center - Madison | Flowood | Mississippi | 39232 | — |
| Southern Therapy and Advanced Research | Jackson | Mississippi | 39216 | — |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| St. Luke's Hospital Of Kansas City | Kansas City | Missouri | 64111 | — |
| Kansas City Research Institute | Kansas City | Missouri | 64131 | — |
| Saint Louis University | St Louis | Missouri | 63104 | — |
| Clinical Research US - Henderson | Henderson | Nevada | 89052 | — |
| Mt. Sinai Medical Center | New York | New York | 10029 | — |
| New York Presbyterian Hospital | New York | New York | 10065 | — |
| University of North Carolina Medical Center - Chapel Hill | Charlotte | North Carolina | 27599 | — |
| Duke University Medical Center | Durham | North Carolina | 27705 | — |
| Cumberland Research Associates | Fayetteville | North Carolina | 28304 | — |
| Lucas Research | Morehead City | North Carolina | 28557 | — |
| Consultants for Clinical Research | Cincinnati | Ohio | 45249 | — |
| Aventiv Research - Columbus | Columbus | Ohio | 43213 | — |
| Awasty Research Network | Marion | Ohio | 43302 | — |
| Premier Medical Group - Clarksville | Clarksville | Tennessee | 37040 | — |
| Gastro One - Germantown - Centre Oak Way | Germantown | Tennessee | 38138 | — |
| Associates in Gastroenterology | Hermitage | Tennessee | 37076 | — |
| Gastrointestinal Associates - Knoxville | Knoxville | Tennessee | 37909 | — |
| South Texas Research Institute - Brownsville | Brownsville | Texas | 78520 | — |
| Dallas Research Center | Dallas | Texas | 75234 | — |
| Liver Center of Texas | Dallas | Texas | 75234 | — |
| Texas Digestive Disease Consultants - Dallas | Dallas | Texas | 75234 | — |
| The Liver Institute at Methodist Dallas Medical Center | Dallas | Texas | 75234 | — |
| South Texas Research Institute | Edinburg | Texas | 78539 | — |
| Brooke Army Medical Center | Fort Sam Houston | Texas | 78234 | — |
| Texas Digestive Disease Consultants - Fort Worth | Fort Worth | Texas | 76104 | — |
| Liver Associates of Texas | Houston | Texas | 77030 | — |
| Doctor's Hospital at Renaissance | McAllen | Texas | 78504 | — |
| Plano Research Center | Plano | Texas | 75093 | — |
| Pinnacle Clinical Research - Austin | Rollingwood | Texas | 78746 | — |
| Pinnacle Clinical Research | San Antonio | Texas | 78229 | — |
| San Antonio Research Center | San Antonio | Texas | 78229 | — |
| The Texas Liver Institute | San Antonio | Texas | 78229 | — |
| Texas Digestive Disease Consultants - San Marcos | San Marcos | Texas | 78666 | — |
| Impact Research Institute | Waco | Texas | 76710 | — |
| Texas Digestive Disease Consultants - Bay Area Gastroenterology | Webster | Texas | 77598 | — |
| Wasatch Peak Family Practice | Layton | Utah | 84041 | — |
| Salt Lake City Research Center | Murray | Utah | 84123 | — |
| University of Utah Hospital | Salt Lake City | Utah | 84132 | — |
| University of Virginia Health System | Charlottesville | Virginia | 22903 | — |
| Bon Secours St. Mary's Hospital of Richmond | Richmond | Virginia | 23226 | — |
| Hunter Holmes McGuire Veterans Administration Medical Center | Richmond | Virginia | 23249 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23249 | — |
| Liver Institute Northwest | Seattle | Washington | 98105 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 157 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03900429, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 1, 2026 · Synced Oct 30, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03900429 live on ClinicalTrials.gov.