A Study of Daratumumab Plus Lenalidomide Versus Lenalidomide Alone as Maintenance Treatment in Participants With Newly Diagnosed Multiple Myeloma Who Are Minimal Residual Disease Positive After Frontline Autologous Stem Cell Transplant
Public ClinicalTrials.gov record NCT03901963. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Study of Daratumumab Plus Lenalidomide Versus Lenalidomide Alone as Maintenance Treatment in Patients With Newly Diagnosed Multiple Myeloma Who Are Minimal Residual Disease Positive After Frontline Autologous Stem Cell Transplant
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate conversion rate to minimal residual disease (MRD) negativity following the addition of daratumumab to lenalidomide relative to lenalidomide alone, when administered as maintenance treatment to anti-cluster of differentiation 38 (CD38) treatment naive participants with newly diagnosed multiple myeloma who are MRD positive as determined by next generation sequencing (NGS) at screening, following high-dose therapy (HDT) and autologous stem cell transplant (ASCT).
Study identification
- NCT ID
- NCT03901963
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 200 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 79 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 25, 2019
- Primary completion
- Apr 3, 2024
- Completion
- May 3, 2026
- Last update posted
- Jun 22, 2026
2019 – 2026
United States locations
- U.S. sites
- 70
- U.S. states
- 30
- U.S. cities
- 60
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama Birmingham | Birmingham | Alabama | 35294 | — |
| Arizona Oncology Associates, PC - HAL | Glendale | Arizona | 85308 | — |
| Cancer Treatment Center of America Phoenix | Goodyear | Arizona | 85338 | — |
| University of California San Diego (UCSD) - The Rebecca and John Moores Cancer Center | La Jolla | California | 92093 | — |
| UCLA David Geffen School of Medicine | Los Angeles | California | 90095 | — |
| University of California San Francisco | San Francisco | California | 94143 | — |
| Colorado Blood Cancer Institute | Denver | Colorado | 80218 | — |
| Rocky Mountain Cancer Centers | Denver | Colorado | 80218 | — |
| University of Colorado Health | Fort Collins | Colorado | 80528 | — |
| Yale University Medical Center | New Haven | Connecticut | 06510 | — |
| MedStar Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32256 | — |
| University of Miami Sylvester Cancer Center | Miami | Florida | 33136 | — |
| Miami Cancer Institute | Miami | Florida | 33176 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Cleveland Clinic Florida | Weston | Florida | 33331 | — |
| University Cancer And Blood Center LLC | Athens | Georgia | 30607 | — |
| Illinois Cancer Specialists | Niles | Illinois | 60714 | — |
| Cancer Treatment Centers of America | Zion | Illinois | 60099 | — |
| Fort Wayne Medical Oncology and Hematology American Oncology Partners | Fort Wayne | Indiana | 46804 | — |
| Franciscan Health | Indianapolis | Indiana | 46237-8601 | — |
| University of Kansas Cancer Center | Westwood | Kansas | 66160 | — |
| Norton Cancer Institute | Louisville | Kentucky | 40207 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| University of Maryland Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Henry Ford Cancer - Detroit Brigitte Harris Cancer Pavilion | Detroit | Michigan | 48202 | — |
| Cancer And Hematology Centers of Western Michigan PC | Grand Rapids | Michigan | 49503 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| HCA MidAmerica Division Inc Research Medical Center | Kansas City | Missouri | 64132 | — |
| Summit Medical Group/MD Anderson Cancer Center | Florham Park | New Jersey | 07932 | — |
| Rutgers, The State Univ of NJ-Robert Wood Johnson Medical School-The Cancer Institute of NJ (CINJ) | New Brunswick | New Jersey | 08901-1914 | — |
| New York Oncology Hematology | Albany | New York | 12206 | — |
| Northwell Health | Lake Success | New York | 11042 | — |
| NYU Winthrop | Mineola | New York | 11501 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| Montefiore Einstein Center for Cancer Care | The Bronx | New York | 10467 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27599-7305 | — |
| Levine Cancer Institute, Carolinas HealthCare System | Charlotte | North Carolina | 28204 | — |
| Novant Health Charlotte | Charlotte | North Carolina | 28204 | — |
| Novant Health | Winston-Salem | North Carolina | 27103 | — |
| Wake Forest Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Oncology Hematology Care | Cincinnati | Ohio | 45236 | — |
| Northwest Cancer Specialists PC | Portland | Oregon | 97227 | — |
| Oregon Health And Science University | Portland | Oregon | 97239 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107-4215 | — |
| Temple University Hospital Jeanes Campus | Philadelphia | Pennsylvania | 19111 | — |
| West Penn Hospital | Pittsburgh | Pennsylvania | 15224 | — |
| University Of Pittsburgh Medical Center UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| Reading Hospital/McGlinn Cancer Institute | West Reading | Pennsylvania | 19611 | — |
| Greenville Health System Cancer Institute | Greenville | South Carolina | 29615-4816 | — |
| Spartanburg Regional Health Services | Spartanburg | South Carolina | 29303 | — |
| Tennessee Oncology Chattanooga | Chattanooga | Tennessee | 37404 | — |
| Baptist Cancer Center | Memphis | Tennessee | 38120 | — |
| Tennessee Oncology | Nashville | Tennessee | 37203 | — |
| Texas Oncology-Central South | Austin | Texas | 78745 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75235 | — |
| Texas Oncology P A 1 | Dallas | Texas | 75246 | — |
| MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Mays Cancer Center (UT Health San Antonio) | San Antonio | Texas | 78229 | — |
| Texas Oncology P A | Tyler | Texas | 75702 | — |
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | — |
| University of Virginia Cancer Center - Emily Couric Clinical Cancer Center - Women's Oncology Clinic | Charlottesville | Virginia | 22903 | — |
| Virginia Cancer Specialists | Fairfax | Virginia | 22031 | — |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | — |
| VA Puget Sound Healthcare System | Seattle | Washington | 98108 | — |
| University of Washington | Seattle | Washington | 98109 | — |
| Cancer Care Northwest | Spokane | Washington | 99216 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03901963, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 22, 2026 · Synced Sep 29, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03901963 live on ClinicalTrials.gov.