ClinicalTrials.gov record
Phase 3 Study of Sitravatinib Plus Nivolumab vs Docetaxel in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer
ClinicalTrials.gov ID: NCT03906071
Public ClinicalTrials.gov record NCT03906071. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 17, 2026, 2:40 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase 3 Study of Sitravatinib in Combination With Nivolumab Versus Docetaxel in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer With Disease Progression On or After Platinum-Based Chemotherapy and Checkpoint Inhibitor Therapy SAPPHIRE
Study identification
- NCT ID
- NCT03906071
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Mirati Therapeutics Inc.
- Industry
- Enrollment
- 577 participants
Conditions and interventions
Interventions
- Docetaxel Drug
- Nivolumab Biological
- Sitravatinib Drug
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 14, 2019
- Primary completion
- Mar 19, 2023
- Completion
- Sep 29, 2025
- Last update posted
- Oct 20, 2025
2019 – 2025
United States locations
- U.S. sites
- 133
- U.S. states
- 34
- U.S. cities
- 112
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 005-164 | Birmingham | Alabama | 35243 | — |
| Clearview Cancer Institute - Huntsville | Huntsville | Alabama | 35805 | — |
| Palo Verde Cancer Specialists - Glendale | Glendale | Arizona | 85304 | — |
| The Oncology Institute of Hope & Innovation - Tucson | Tucson | Arizona | 85745 | — |
| Yuma Regional Medical Center | Yuma | Arizona | 85364 | — |
| Local Institution - 005-174 | Jonesboro | Arkansas | 72401 | — |
| NEA Baptist Fowler Family Center for Cancer Care | Jonesboro | Arkansas | 72401 | — |
| Highlands Oncology Group - Springdale | Springdale | Arkansas | 72762 | — |
| Comprehensive Blood and Cancer Center - Bakersfield | Bakersfield | California | 93309 | — |
| Local Institution - 005-118 | Beverly Hills | California | 90211 | — |
| Local Institution - 005-171 | Fresno | California | 93720 | — |
| Providence Medical Foundation - Virginia K. Crosson Cancer Center - Fullerton | Fullerton | California | 92835 | — |
| Local Institution - 005-096 | Long Beach | California | 90813 | — |
| Cancer and Blood Specialty Clinic | Los Alamitos | California | 90720 | — |
| Los Angeles Hematology Oncology Medical Group | Los Angeles | California | 90017 | — |
| Local Institution - 005-185 | Los Angeles | California | 90095 | — |
| Local Institution - 005-072 | Newport Beach | California | 92663 | — |
| Local Institution - 005-109 | Northridge | California | 91325 | — |
| Local Institution - 005-177 | Redlands | California | 92373 | — |
| Local Institution - 005-112 | Riverside | California | 92501 | — |
| University of California San Francisco | San Francisco | California | 94143 | — |
| Local Institution - 005-176 | San Marcos | California | 92069 | — |
| Local Institution - 005-192 | Torrance | California | 90505 | — |
| Local Institution - 005-090 | West Covina | California | 91790 | — |
| Local Institution - 005-105 | Whittier | California | 90602 | — |
| Local Institution - 005-097 | Lafayette | Colorado | 80026 | — |
| Eastern Connecticut Hematology and Oncology Associates | Norwich | Connecticut | 06360 | — |
| Michael and Dianne Bienes Comprehensive Cancer Center | Fort Lauderdale | Florida | 33308 | — |
| Local Institution - 005-120 | Fort Myers | Florida | 33901 | — |
| Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| Watson Clinic Cancer and Research Center | Lakeland | Florida | 33805 | — |
| Mount Sinai Health System | Miami Beach | Florida | 33140 | — |
| Local Institution - 005-120E | Naples | Florida | 34102 | — |
| Local Institution - 005-079 | Ocala | Florida | 34474 | — |
| Local Institution - 005-104 | Orlando | Florida | 32804 | — |
| SCRI - Florida Cancer Specialists - North Region Research Office | St. Petersburg | Florida | 33705 | — |
| SCRI - Florida Cancer Specialists - Panhandle Research Office | Tallahassee | Florida | 32308 | — |
| Local Institution - 005-154 | West Palm Beach | Florida | 33401 | — |
| University Cancer & Blood Center (UCBC) - Athens | Athens | Georgia | 30607 | — |
| Local Institution - 005-146 | Atlanta | Georgia | 30318 | — |
| John B. Amos Cancer Center Research | Columbus | Georgia | 31904 | — |
| Local Institution - 005-119 | Marietta | Georgia | 30060 | — |
| Straub Medical Center | Honolulu | Hawaii | 96813 | — |
| Local Institution - 005-191 | Coeur d'Alene | Idaho | 83814 | — |
| Local Institution - 005-151 | Chicago | Illinois | 60625-3645 | — |
| Local Institution - 005-110 | Evanston | Illinois | 60201 | — |
| Local Institution - 005-198 | Niles | Illinois | 60714 | — |
| Orchard Healthcare Research | Skokie | Illinois | 60077 | — |
| Healthcare Research Network - Tinley Park | Tinley Park | Illinois | 60487 | — |
| Fort Wayne Medical Oncology and Hematology - Fort Wayne South Office | Fort Wayne | Indiana | 46804 | — |
| Local Institution - 005-122 | Goshen | Indiana | 46526 | — |
| Franciscan Health Cancer Center Indianapolis | Indianapolis | Indiana | 46237 | — |
| Local Institution - 005-150 | Lafayette | Indiana | 47904 | — |
| Local Institution - 005-169 | Westwood | Kansas | 66205 | — |
| Local Institution - 005-098 | Wichita | Kansas | 67214 | — |
| Commonwealth Cancer Center - Frankfort | Danville | Kentucky | 40422 | — |
| Local Institution - 005-153 | Louisville | Kentucky | 40241 | — |
| New England Cancer Specialists - Scarborough | Scarborough | Maine | 04074 | — |
| Local Institution - 005-178 | Rockville | Maryland | 20850-6535 | — |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Local Institution - 005-127 | Minneapolis | Minnesota | 55404 | — |
| Local Institution - 005-159 | Saint Louis Park | Minnesota | 55426-5000 | — |
| Jackson Oncology Associates - The Hederman Cancer Center | Jackson | Mississippi | 39202 | — |
| Central Care Cancer Center - Bolivar | Bolivar | Missouri | 65613 | — |
| Kansas City Care Health Center - Research Medical Campus | Kansas City | Missouri | 64132 | — |
| Sisters of Charity of Leavenworth Health St. Marys | Billings | Montana | 59102 | — |
| Saint Francis Cancer Treatment Center | Grand Island | Nebraska | 68803 | — |
| Methodist Hospital - Omaha | Omaha | Nebraska | 68114 | — |
| The Oncology Institute of Hope & Innovation - Henderson | Henderson | Nevada | 89052 | — |
| Local Institution - 005-152 | Henderson | Nevada | 89074 | — |
| Local Institution - 005-142 | Florham Park | New Jersey | 07932 | — |
| Local Institution - 005-163 | Little Silver | New Jersey | 07739 | — |
| Cooperman Barnabas Medical Center | Livingston | New Jersey | 07039 | — |
| Regional Cancer Care Associates - Sparta | Sparta | New Jersey | 07871 | — |
| Local Institution - 005-123 | Johnson City | New York | 13790 | — |
| Local Institution - 005-182 | Lake Success | New York | 11042 | — |
| New York Cancer & Blood Specialists - Port Jefferson Medical Oncology | Port Jefferson Station | New York | 11776 | — |
| Local Institution - 005-107 | Stony Brook | New York | 11794 | — |
| Local Institution - 005-196 | Canton | Ohio | 44708 | — |
| USOR - Oncology Hematology Care - Blue Ash | Cincinnati | Ohio | 45242 | — |
| Local Institution - 005-181 | Columbus | Ohio | 43210 | — |
| Tricounty Hematology and Oncology - Massillon | Massillon | Ohio | 44646 | — |
| Local Institution - 005-103 | Toledo | Ohio | 43623 | — |
| Local Institution - 005-088 | Oklahoma City | Oklahoma | 73120 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Local Institution - 005-073 | Portland | Oregon | 97239 | — |
| USOR - Alliance Cancer Specialists - Horsham (Abington Hematology Oncology Associates) | Horsham | Pennsylvania | 19044 | — |
| Local Institution - 005-186 | Philadelphia | Pennsylvania | 19111 | — |
| Local Institution - 005-137A | Dickson | Tennessee | 37055 | — |
| Local Institution - 005-137B | Dickson | Tennessee | 37055 | — |
| Local Institution - 005-137C | Dickson | Tennessee | 37055 | — |
| Local Institution - 005-137D | Dickson | Tennessee | 37055 | — |
| Local Institution - 005-137E | Dickson | Tennessee | 37055 | — |
| Local Institution - 005-137F | Dickson | Tennessee | 37055 | — |
| Local Institution - 005-137G | Dickson | Tennessee | 37055 | — |
| Local Institution - 005-137H | Dickson | Tennessee | 37055 | — |
| Local Institution - 005-137I | Dickson | Tennessee | 37055 | — |
| Local Institution - 005-137J | Dickson | Tennessee | 37055 | — |
| Local Institution - 005-137K | Dickson | Tennessee | 37055 | — |
| Local Institution - 005-137L | Dickson | Tennessee | 37055 | — |
| Local Institution - 005-137M | Hendersonville | Tennessee | 37075 | — |
| Local Institution - 005-195 | Memphis | Tennessee | 38120 | — |
| Local Institution - 005-137 | Nashville | Tennessee | 37203 | — |
| Local Institution - 005-134 | Austin | Texas | 78745 | — |
| Local Institution - 005-075 | Beaumont | Texas | 77702 | — |
| Local Institution - 005-128 | Dallas | Texas | 75203 | — |
| Local Institution - 005-129 | Dallas | Texas | 75231 | — |
| Local Institution - 005-126 | Dallas | Texas | 75246 | — |
| USOR - Texas Oncology Northeast Texas - Denison | Denison | Texas | 75020 | — |
| Local Institution - 005-124 | Denton | Texas | 76201 | — |
| The Center for Cancer & Blood Disorders - Fort Worth | Fort Worth | Texas | 76104 | — |
| Oncology Consultants - Texas Medical Center | Houston | Texas | 77030 | — |
| Local Institution - 005-076 | Houston | Texas | 77070 | — |
| Millennium Research and Clinical Development | Houston | Texas | 77090 | — |
| USOR - US Oncology Investigational Products Center | Irving | Texas | 75063 | — |
| Local Institution - 005-125 | McKinney | Texas | 75071 | — |
| Texas Oncology - San Antonio Medical Center | San Antonio | Texas | 78240 | — |
| USOR - Texas Oncology - Sugar Land | Sugar Land | Texas | 77479 | — |
| USOR - Texas Oncology Northeast Texas - Cancer and Research Institute - Tyler | Tyler | Texas | 75702 | — |
| Local Institution - 005-144 | Charlottesville | Virginia | 22903 | — |
| Hematology Oncology Associates of Fredericksburg | Fredericksburg | Virginia | 24408 | — |
| Virginia Cancer Institute - West End | Richmond | Virginia | 23229 | — |
| Overlake Medical Center and Clinics | Bellevue | Washington | 98004 | — |
| Local Institution - 005-082 | Everett | Washington | 98201 | — |
| Local Institution - 005-111 | Seattle | Washington | 98109--1023 | — |
| Local Institution - 005-187 | Spokane | Washington | 99218 | — |
| Local Institution - 005-081 | Tacoma | Washington | 98405 | — |
| Northwest Medical Specialties - Tacoma | Tacoma | Washington | 98405 | — |
| Local Institution - 005-136 | Vancouver | Washington | 98684 | — |
| ThedaCare Regional Cancer Center | Appleton | Wisconsin | 54911 | — |
| Local Institution - 005-116 | Madison | Wisconsin | 53792 | — |
| Froedtert Hospital | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 128 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03906071, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 20, 2025 · Synced May 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03906071 live on ClinicalTrials.gov.