Trial to Evaluate Reduction in Inflammation in Patients With Advanced Chronic Renal Disease Utilizing Antibody Mediated IL-6 Inhibition
Public ClinicalTrials.gov record NCT03926117. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate Reduction in Inflammation in Patients With Advanced Chronic Renal Disease Utilizing Antibody Mediated IL-6 Inhibition
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Patients with chronic kidney disease, who have evidence of systemic inflammation with increased cardiovascular risk, will be enrolled into this trial. The purpose of this trial is to determine a dose to select for a potential cardiovascular outcome trial with Ziltivekimab. Doses to be tested will be 7.5 mg, 15 mg and 30 mg subcutaneous monthly compared to placebo for six months.
Study identification
- NCT ID
- NCT03926117
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 264 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 3, 2019 (Actual)
- Primary completion
- Jun 26, 2020 (Actual)
- Completion
- Jun 26, 2020 (Actual)
- Last update posted
- Dec 31, 2025
2019 – 2020
United States locations
- U.S. sites
- 49
- U.S. states
- 23
- U.S. cities
- 43
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Central Alabama Research | Birmingham | Alabama | 35205 | — |
| Aventiv Research | Mesa | Arizona | 85210 | — |
| Arizona Kidney Disease and Hypertension Center | Phoenix | Arizona | 85016 | — |
| Elite Clinical Studies | Phoenix | Arizona | 85018 | — |
| North America Research Institute | Lynwood | California | 90262 | — |
| North America Research Institute | Riverside | California | 92503 | — |
| Apex Research of Riverside | Riverside | California | 92505 | — |
| North America Research Institute | San Dimas | California | 91773 | — |
| Western Nephrology and Metabolic Bone Disease, PC | Arvada | Colorado | 80002 | — |
| AMPM Research Clinic | Miami | Florida | 33169 | — |
| Ocala Cardiovascular Research | Ocala | Florida | 34474 | — |
| Florida Premier Research Institue, LLC | Winter Park | Florida | 32789 | — |
| Southeastern Clinical Research Institute, LLC | Augusta | Georgia | 30901 | — |
| Columbus Regional Research Institute | Columbus | Georgia | 31904 | — |
| Investigator Research by Design, LLC | Chicago | Illinois | 60643 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| Clinical Trials of America, LLC - West Monroe | Monroe | Louisiana | 71201 | — |
| Capital Nephrology | Greenbelt | Maryland | 20770 | — |
| Onyx Clinical Research | Caro | Michigan | 48723 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| St. Clair Nephrology Research | Roseville | Michigan | 48066 | — |
| Nephrology Research of Michigan | Saint Clair Shores | Michigan | 48081 | — |
| DaVita Clinical Research | Minneapolis | Minnesota | 55404 | — |
| Julia and Israel Waldbaum Dialysis Center | Great Neck | New York | 11021 | — |
| Northport VAMC | Northport | New York | 11768 | — |
| DaVita Clinical Research | The Bronx | New York | 10461 | — |
| Mountain Kidney and Hypertension Associates | Asheville | North Carolina | 28801 | — |
| Metrolina Nephrology Associates, PA | Charlotte | North Carolina | 28207 | — |
| Metrolina Nephrology Associates | Charlotte | North Carolina | 28277 | — |
| Southeastern Nephrology - Whiteville | Whiteville | North Carolina | 28472 | — |
| Southeastern Nephrology Associates - Wilmington | Wilmington | North Carolina | 28401 | — |
| Summit Research Group, LLC | Stow | Ohio | 44224 | — |
| Northeast Clinical Research Center | Allentown | Pennsylvania | 18104 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Piedmont Research Partners, LLC | Fort Mill | South Carolina | 29707 | — |
| Mountain View CLinical Research - Greer | Greer | South Carolina | 29651 | — |
| Knoxville Kidney Center, PLLC | Knoxville | Tennessee | 37923 | — |
| Nephrology Associates, PC | Nashville | Tennessee | 37205 | — |
| Renal Disease Research Institute | Dallas | Texas | 75246 | — |
| Vilo Research Group, Inc | Houston | Texas | 77017 | — |
| Biopharma Informatick Inc. Research Center | Houston | Texas | 77043 | — |
| Juno Research, LLC - Northwest | Houston | Texas | 77070 | — |
| North Hills Medical Research, Inc | North Richland Hills | Texas | 76180 | — |
| Clinical Advancement Center, PLLC | San Antonio | Texas | 78212 | — |
| San Antonio Kidney Disease Center Physicians Group, PLLC | San Antonio | Texas | 78229 | — |
| University of Vermont | Burlington | Vermont | 05401 | — |
| Southside Urology and Nephrology | Danville | Virginia | 25241 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| Clinical Investigation Specialist, Inc | Kenosha | Wisconsin | 53142 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03926117, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 31, 2025 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03926117 live on ClinicalTrials.gov.