ASCEND GO-2: Study of RVT-1401 for the Treatment of Participants With Active, Moderate to Severe Graves' Ophthalmopathy ( GO )
Public ClinicalTrials.gov record NCT03938545. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
ASCEND GO-2: A Phase 2b, Multicenter, Randomized, Double-blind, Placebo-controlled Study of RVT-1401 for the Treatment of Patients With Active, Moderate to Severe Graves' Ophthalmopathy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the current study is to assess the efficacy and safety/tolerability of three dose regimens of RVT-1401 in the treatment of active, moderate to severe GO participants. In addition, the study is designed to characterize the effect of RVT-1401 exposure on reduction in anti-TSHR IgG
Study identification
- NCT ID
- NCT03938545
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 65 participants
Conditions and interventions
Conditions
Interventions
- RVT-1401 (Administered via subcutaneous injection) Drug
- Placebo (Administered via subcutaneous injection) Other
Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 23, 2019 (Actual)
- Primary completion
- Feb 2, 2021 (Actual)
- Completion
- Apr 15, 2021 (Actual)
- Last update posted
- Sep 22, 2022
2019 – 2021
United States locations
- U.S. sites
- 12
- U.S. states
- 11
- U.S. cities
- 12
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Multispecialty Aesthetic Clinical Research Organziation (MACRO) | Beverly Hills | California | 90212 | — |
| Doheny Eye Center UCLA | Pasadena | California | 91105 | — |
| University of Miami Miller School of Medicine Bascom Palmer Eye Institute | Miami | Florida | 33136 | — |
| University of Iowa Hospitals & Clinics - Eye Clinic | Iowa City | Iowa | 52242 | — |
| University of Michigan - Kellogg Eye Center | Ann Arbor | Michigan | 48105 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Washington University School of Medicine - Center for Advanced Medicine (CAM) - Eye Center | St Louis | Missouri | 63146 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Oregon Health & Science University (OHSU) - Casey Eye Institute (CEI)-Marquam Hill | Portland | Oregon | 97239 | — |
| Eye Wellness Center | Houston | Texas | 77005 | — |
| Eyelid Center of Utah | Salt Lake City | Utah | 84102 | — |
| West Virginia University Eye Institute | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 13 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03938545, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 22, 2022 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03938545 live on ClinicalTrials.gov.