A Study of Tepotinib Plus Osimertinib in Osimertinib Relapsed MET Amplified NSCLC (INSIGHT 2)
Public ClinicalTrials.gov record NCT03940703. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II, Two-arm Study to Investigate Tepotinib Combined With Osimertinib in MET Amplified, Advanced or Metastatic NSCLC Harboring Activating EGFR Mutations and Having Acquired Resistance to Prior Osimertinib Therapy (INSIGHT 2)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study was to assess the antitumor activity, safety, tolerability, and pharmacokinetics (PK) of the Mesenchymal-epithelial Transition Factor (MET) inhibitor tepotinib combined with the 3rd generation EGFR inhibitor osimertinib in participants with advanced or metastatic non-small cell lung cancer (NSCLC).
Study identification
- NCT ID
- NCT03940703
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 140 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 19, 2019 (Actual)
- Primary completion
- May 11, 2023 (Actual)
- Completion
- Jul 15, 2026 (Actual)
- Last update posted
- Aug 21, 2026
2019 – 2026
United States locations
- U.S. sites
- 49
- U.S. states
- 28
- U.S. cities
- 46
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Yuma Regional Medical Center | Yuma | Arizona | 85364 | — |
| Compassionate Care Research Group Inc - Edinger Medical Group, Inc. | Fountain Valley | California | 92708 | — |
| Memorial Care | Long Beach | California | 90806 | — |
| Ventura County Hematology Oncology Specialists | Oxnard | California | 93030 | — |
| Innovative Clinical Research Institute | Whittier | California | 92801 | — |
| Eastern Connecticut Hematology & Oncology Associates | Norwich | Connecticut | 06360 | — |
| Holy Cross | Fort Lauderdale | Florida | 33308 | — |
| Memorial Healthcare System | Hollywood | Florida | 33021 | — |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32256 | — |
| Ocala Oncology | Ocala | Florida | 34474 | — |
| University Cancer and Blood Center | Athens | Georgia | 30607 | — |
| Hawaii Cancer Care | Honolulu | Hawaii | 96813 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Fort Wayne Medical Oncology and Hematology | Fort Wayne | Indiana | 46845 | — |
| Community Health Network | Indianapolis | Indiana | 46250 | — |
| Beacon Health | South Bend | Indiana | 46601 | — |
| Norton Cancer Institute | Louisville | Kentucky | 40202 | — |
| Pontchartrain | Hammond | Louisiana | 70433 | — |
| Medstar Franklin Square Clinical Research Center | Baltimore | Maryland | 21237 | — |
| The Center for Cancer & Blood Disorders - Maryland | Bethesda | Maryland | 20817 | — |
| Frederick Health- James M Stockman Cancer Institute | Frederick | Maryland | 21702 | — |
| Boston Medical Center - Dept. Hematology/Oncology | Boston | Massachusetts | 02118 | — |
| Southcoast Center for Cancer Care | Fairhaven | Massachusetts | 02719 | — |
| Sparrow Hospital Herbert - Herman Cancer Center | Lansing | Michigan | 48912 | — |
| Central Care Cancer Center (CCCC) | Bolivar | Missouri | 65613 | — |
| St. Louis Cancer Care, LLP | Bridgeton | Missouri | 63044 | — |
| Mosaic Life Care | Saint Joseph | Missouri | 64507 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89169 | — |
| New Jersey Cancer Care and Blood Disorders | Belleville | New Jersey | 07109 | — |
| Summit Medical Group | Florham Park | New Jersey | 07932 | — |
| NYU Langone Clinical Cancer Center - NYU Langone Medical Center | New York | New York | 10016 | — |
| NYU Langone Clinical Cancer Center - NYU Langone Medical Cente | New York | New York | 10016 | — |
| Weill Cornell Medical College - Gastroenterology | New York | New York | 10021 | — |
| Southeastern Medical Oncology Center | Goldsboro | North Carolina | 27534 | — |
| University Hospitals Seidman | Cleveland | Ohio | 44106 | — |
| OhioHealth | Columbus | Ohio | 43214 | — |
| Oklahoma Cancer Specialists and Research Institute | Tulsa | Oklahoma | 74146 | — |
| Oregon Oncology Specialists | Salem | Oregon | 97301 | — |
| Gettysburg Cancer Center | Gettysburg | Pennsylvania | 17325 | — |
| Sanford Health | Sioux Falls | South Dakota | 57104 | — |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57108 | — |
| Baptist Cancer Center | Memphis | Tennessee | 38120 | — |
| Tennessee Oncology | Nashville | Tennessee | 37201 | — |
| Mary Crowley Cancer Research | Dallas | Texas | 75230 | — |
| University of Texas MD Anderson Cancer Center - Unit 432 Thoracic Head and Neck Medical Oncology | Houston | Texas | 77030 | — |
| Community Cancer Trials of Utah | Ogden | Utah | 84405 | — |
| Utah Cancer Specialists | Salt Lake City | Utah | 84106 | — |
| Hematology Oncology Associates of Fredericksburg | Fredericksburg | Virginia | 22408 | — |
| Northwest Medical Specialties | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 130 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03940703, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 21, 2026 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03940703 live on ClinicalTrials.gov.