Zephyrus I: Evaluation of Efficacy and Safety of Pamrevlumab in Participants With Idiopathic Pulmonary Fibrosis (IPF)
Public ClinicalTrials.gov record NCT03955146. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Pamrevlumab in Subjects With Idiopathic Pulmonary Fibrosis (IPF)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 3 trial to evaluate the efficacy and safety of 30 milligrams (mg)/kilogram (kg) intravenous (IV) infusions of pamrevlumab administered every 3 weeks as compared to placebo in participants with IPF.
Study identification
- NCT ID
- NCT03955146
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 393 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 18, 2019 (Actual)
- Primary completion
- Mar 20, 2023 (Actual)
- Completion
- Aug 28, 2023 (Actual)
- Last update posted
- Sep 19, 2024
2019 – 2023
United States locations
- U.S. sites
- 60
- U.S. states
- 31
- U.S. cities
- 53
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Hospital | Birmingham | Alabama | 35294 | — |
| Banner University Medical Center - Phoenix | Phoenix | Arizona | 85006 | — |
| Norton Thoracic Institute | Phoenix | Arizona | 85013 | — |
| Pulmonary Associates, PA - Research | Phoenix | Arizona | 85032 | — |
| University of Arizona | Tucson | Arizona | 85724 | — |
| J&L Research | Conway | Arkansas | 72032 | — |
| Loma Linda University Health | Loma Linda | California | 92354 | — |
| David Geffen School of Medicine at UCLA | Los Angeles | California | 90095 | — |
| UC Davis Medical Center | Sacramento | California | 95817 | — |
| University of California San Diego | San Diego | California | 92103 | — |
| Stanford University Medical Center | Stanford | California | 94305 | — |
| University of Colorado Denver | Aurora | Colorado | 80045 | — |
| National Jewish Health | Denver | Colorado | 80207 | — |
| Yale University School of Medicine | New Haven | Connecticut | 06510 | — |
| Medstar Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| St. Francis Medical Center | Clearwater | Florida | 33765 | — |
| University of Florida Pulmonary, Critical Care & Sleep Medicine Division | Gainesville | Florida | 32610 | — |
| University of Florida Health, Jacksonville | Jacksonville | Florida | 32209 | — |
| Mayo Clinic | Jacksonville | Florida | 32224 | — |
| Pulmonary Disease Specialist, PA d/b/a, PDS Research | Kissimmee | Florida | 34741 | — |
| University of South Florida | Tampa | Florida | 33606 | — |
| Emory University | Atlanta | Georgia | 30322 | — |
| Piedmont Healthcare, Inc. | Austell | Georgia | 30106 | — |
| Northwestern University | Chicago | Illinois | 60612 | — |
| Loyola University of Chicago | Maywood | Illinois | 60153 | — |
| Indiana University School of Medicine | Indianapolis | Indiana | 46202 | — |
| The University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| University of Maryland, Baltimore | Baltimore | Maryland | 21201 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Spectrum Health | Grand Rapids | Michigan | 49546 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| The Lung Research Center, LLC | Chesterfield | Missouri | 63017 | — |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Albany Medical College | Albany | New York | 12208 | — |
| Pulmonary Health Physicians, PC | Liverpool | New York | 13088 | — |
| Pulmonix, LLC | Greensboro | North Carolina | 27403 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| Ohio State University | Columbus | Ohio | 43221 | — |
| INTEGRIS Baptist Medical Center | Oklahoma City | Oklahoma | 73112 | — |
| Legacy Research Institute | Portland | Oregon | 97210 | — |
| The Oregon Clinic | Portland | Oregon | 97220 | — |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Temple University | Philadelphia | Pennsylvania | 19140 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Lowcountry Lung and Critical Care, PA | Charleston | South Carolina | 29406 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Tennessee Comprehensive Lung and Sleep Center | Hendersonville | Tennessee | 37075 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37204 | — |
| Houston Pulmonary Sleep, Allergy and Asthma Associates | Cypress | Texas | 77429 | — |
| Baylor Scott and White Research Institute | Dallas | Texas | 75246 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| University of Texas - Houston | Houston | Texas | 77030 | — |
| UT Health San Antonio | San Antonio | Texas | 78229 | — |
| Renovatio Clinical | The Woodlands | Texas | 77380 | — |
| University of Utah Health | Salt Lake City | Utah | 84108 | — |
| The University of Vermont | Burlington | Vermont | 05405 | — |
| University of Washington | Seattle | Washington | 98195 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 65 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03955146, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 19, 2024 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03955146 live on ClinicalTrials.gov.