ClinicalTrials.gov record
MEK Inhibitor Mirdametinib (PD-0325901) in Patients With Neurofibromatosis Type 1 Associated Plexiform Neurofibromas
ClinicalTrials.gov ID: NCT03962543
Public ClinicalTrials.gov record NCT03962543. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 8, 2026, 8:09 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b Trial of the MEK 1/2 Inhibitor (MEKi) PD-0325901 in Adult and Pediatric Patients With Neurofibromatosis Type 1 (NF1)-Associated Inoperable Plexiform Neurofibromas (PNs) That Are Causing Significant Morbidity
Study identification
- NCT ID
- NCT03962543
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany
- Industry
- Enrollment
- 114 participants
Conditions and interventions
Interventions
- Mirdametinib (PD-0325901) oral capsule or dispersible tablet Drug
Drug
Eligibility (public fields only)
- Age range
- 2 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 28, 2019
- Primary completion
- Sep 19, 2023
- Completion
- Dec 21, 2028
- Last update posted
- May 5, 2026
2019 – 2028
United States locations
- U.S. sites
- 50
- U.S. states
- 29
- U.S. cities
- 45
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham/Children's of Alabama | Birmingham | Alabama | 35233 | — |
| Mayo Clinic Hospital | Phoenix | Arizona | 85054 | — |
| Arkansas Children's Hospital | Little Rock | Arkansas | 72202 | — |
| Children's Hospital Los Angeles | Los Angeles | California | 90027 | — |
| UCLA Oncology Center | Los Angeles | California | 90095 | — |
| University of California - Irvine Health | Orange | California | 92868-3201 | — |
| Children's Hospital of Orange County | Orange | California | 92868 | — |
| Lucile Packard Children's Hospital Stanford | Palo Alto | California | 94304 | — |
| University of California - Davis Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| Children's Hospital Colorado | Aurora | Colorado | 80045 | — |
| Nemours A. I. duPont Hospital for Children | Wilmington | Delaware | 19803 | — |
| Children's National Medical Center | Washington D.C. | District of Columbia | 20010 | — |
| University of Florida Clinical Research Center | Gainesville | Florida | 32610 | — |
| Nicklaus Children's Hospital | Miami | Florida | 33155 | — |
| AdventHealth Pediatric Oncology Hematology at Orlando | Orlando | Florida | 32804 | — |
| Orlando Health, Inc. | Orlando | Florida | 32806 | — |
| Johns Hopkins All Children's Hospital | St. Petersburg | Florida | 33701 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Children's Healthcare of Atlanta - Center for Advanced Pediatrics | Atlanta | Georgia | 30329 | — |
| University of Illinois Hospital and Health Systems | Chicago | Illinois | 60612 | — |
| University of Chicago Medical Centers | Chicago | Illinois | 60637 | — |
| IU Health Brain Tumor Infusion Clinic | Indianapolis | Indiana | 46202 | — |
| University of Iowa Hospitals & Clinics | Iowa City | Iowa | 52242 | — |
| Kosair Charities Pediatric Clinical Research Unit | Louisville | Kentucky | 40202 | — |
| University of Michigan CS Mott Children's Hospital | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| University of Minnesota/Masonic Cancer Center | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Washington University School of Medicine-Siteman Cancer Center | St Louis | Missouri | 63110 | — |
| St. Joseph's Univeristy Medical Center | Paterson | New Jersey | 07503 | — |
| Albany Medical Center | Albany | New York | 12208 | — |
| Children's Hospital at Montefiore | The Bronx | New York | 10467 | — |
| UNC Medical Center | Chapel Hill | North Carolina | 27514 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45219 | — |
| Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | 45229 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Nationwide Children's Hospital | Columbus | Ohio | 43205 | — |
| University of Oklahoma Health Sciences Center, Jimmy Everest Center for Cancer and Blood Disorders in Children | Oklahoma City | Oklahoma | 73104 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Children's Hospital of Pittsburgh UPMC | Pittsburgh | Pennsylvania | 15224 | — |
| Henry-Joyce Cancer Clinic | Nashville | Tennessee | 37232 | — |
| Children's Medical Center | Dallas | Texas | 75235 | — |
| Cook Children's Medical Center | Fort Worth | Texas | 76104 | — |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| University of Utah, Center for Clinical and Translational Sciences | Salt Lake City | Utah | 84108 | — |
| UVA Health, Division of Neuro-Oncology | Charlottesville | Virginia | 22903 | — |
| Children's Hospital of The King's Daughters | Norfolk | Virginia | 23510 | — |
| Swedish Medical Center - Cherry Hill Campus | Seattle | Washington | 98122 | — |
| MACC Fund Research Center | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03962543, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 5, 2026 · Synced May 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03962543 live on ClinicalTrials.gov.