Pediatric Long-Term Follow-up and Rollover Study
Public ClinicalTrials.gov record NCT03975829. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open Label, Multi-center Roll-over Study to Assess Long-term Effect in Pediatric Patients Treated With Tafinlar (Dabrafenib) and/or Mekinist (Trametinib)
Study identification
- NCT ID
- NCT03975829
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 4
- Lead sponsor
- Novartis Pharmaceuticals
- Industry
- Enrollment
- 165 participants
Conditions and interventions
Conditions
- Anaplastic Astrocytoma
- Anaplastic Ganglioglioma
- Anaplastic Oligodendroglioma
- Anaplastic Pleomorphic Xanthoastrocytoma
- Angiocentric Glioma
- Astrocytoma
- Central Neurocytoma
- Cerebellar Liponeurocytoma
- Chordoid Glioma of Third Ventricle
- Desmoplastic Infantile Astrocytoma and Ganglioglioma
- Diffuse Astrocytoma
- Dysplastic Gangliocytoma of Cerebrellum
- Extraventricular Neurocytoma
- Gangliocytoma
- Ganglioglioma
- Giant Cell Astrocytoma
- Glioblastoma
- Neurofibromatosis Type 1
- Oligodendroglioma, Childhood
- Papillary Glioneuronal Tumor
- Pilocytic Astrocytoma
- Pleomorphic Xanthoastrocytoma
- Rosette-forming Glioneuronal Tumor
Interventions
- dabrafenib Drug
- trametinib Drug
Drug
Eligibility (public fields only)
- Age range
- 1 Year to 99 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 3, 2019
- Primary completion
- Nov 4, 2026
- Completion
- Nov 4, 2026
- Last update posted
- May 4, 2026
2019 – 2026
United States locations
- U.S. sites
- 12
- U.S. states
- 11
- U.S. cities
- 11
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Phoenix Children s Hospital | Phoenix | Arizona | 85016 | Active, not recruiting |
| Childrens National Hospital | Washington D.C. | District of Columbia | 20010 | Active, not recruiting |
| Nicklaus Childrens Hospital | Miami | Florida | 33155 | Active, not recruiting |
| Indiana Uni School of Medicine | Indianapolis | Indiana | 46202-2810 | Active, not recruiting |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | Active, not recruiting |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | Active, not recruiting |
| University of Minnesota | Minneapolis | Minnesota | 55455 | Active, not recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Recruiting |
| Memorial Sloan Kettering Cancer Ctr | New York | New York | 10065 | Active, not recruiting |
| Cinn Children Hosp Medical Center | Cincinnati | Ohio | 45206 | Active, not recruiting |
| St Jude Childrens Research Hospital | Memphis | Tennessee | 38105 | Active, not recruiting |
| Texas Childrens Hospital | Houston | Texas | 77030 | Completed |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 43 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03975829, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 4, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03975829 live on ClinicalTrials.gov.