ClinicalTrials.gov record
A Study to Investigate the Safety and Efficacy of Elsubrutinib and Upadacitinib Given Alone or in Combination in Participants With Moderately to Severely Active Systemic Lupus Erythematosus (SLE)
ClinicalTrials.gov ID: NCT03978520
Public ClinicalTrials.gov record NCT03978520. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 5, 2026, 7:21 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Study to Investigate the Safety and Efficacy of Elsubrutinib and Upadacitinib Given Alone or in Combination (ABBV-599 Combination) in Subjects With Moderately to Severely Active Systemic Lupus Erythematosus
Study identification
- NCT ID
- NCT03978520
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- AbbVie
- Industry
- Enrollment
- 341 participants
Conditions and interventions
Conditions
Interventions
- Elsubrutinib Drug
- Placebo for elsubrutinib Drug
- Placebo for upadacitinib Drug
- Upadacitinib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 24, 2019
- Primary completion
- Jan 18, 2022
- Completion
- Jul 13, 2022
- Last update posted
- Jul 20, 2023
2019 – 2022
United States locations
- U.S. sites
- 47
- U.S. states
- 23
- U.S. cities
- 43
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Arthritis & Rheumatology Research, PLLC /ID# 214522 | Mesa | Arizona | 85210-6871 | — |
| AZ Arthritis and Rheumotology Research, PLLC /ID# 211329 | Phoenix | Arizona | 85032-9306 | — |
| AZ Arthritis and Rheumotology Research, PLLC /ID# 214267 | Phoenix | Arizona | 85032-9306 | — |
| Arthritis and Rheumatism Associates /ID# 211411 | Jonesboro | Arkansas | 72401-6251 | — |
| Wallace Rheumatic Studies Center, LLC /ID# 211600 | Beverly Hills | California | 90211 | — |
| Arthritis & Osteo Medical Ctr /ID# 228235 | La Palma | California | 90623-1728 | — |
| Valerius Medical Group & Research Center /ID# 211599 | Los Alamitos | California | 90720-5402 | — |
| East Bay Rheumatology Medical /ID# 211638 | San Leandro | California | 94578 | — |
| The Lundquist Institute at Harbor-UCLA Medical Center /ID# 213402 | Torrance | California | 90502 | — |
| Medvin Clinical Research /ID# 211996 | Tujunga | California | 91042-2706 | — |
| Inland Rheum Clin Trials Inc. /ID# 213617 | Upland | California | 91786 | — |
| University of Colorado Hospital /ID# 211314 | Aurora | Colorado | 80045 | — |
| Yale University /ID# 212824 | New Haven | Connecticut | 06510 | — |
| Medstar Health Research Institute /ID# 213335 | Washington D.C. | District of Columbia | 20010 | — |
| Arthritis & Rheumatic Disease Specialties /ID# 214052 | Aventura | Florida | 33180 | — |
| LeJenue Research Associates /ID# 212327 | Miami | Florida | 33126 | — |
| Ctr Arthritis & Rheumatic Dise /ID# 212326 | Miami | Florida | 33173 | — |
| Millennium Research /ID# 219099 | Ormond Beach | Florida | 32174 | — |
| IRIS Research and Development, LLC /ID# 213053 | Plantation | Florida | 33324 | — |
| West Broward Rheumatology Associates /ID# 211881 | Tamarac | Florida | 33321 | — |
| BayCare Medical Group, Inc. /ID# 218818 | Tampa | Florida | 33614-7101 | — |
| Affinity Clinical Research /ID# 211496 | Oak Brook | Illinois | 60523-1245 | — |
| Deerbrook Medical Associates /ID# 212251 | Vernon Hills | Illinois | 60061 | — |
| Qualmedica Research, LLC /ID# 214765 | Evansville | Indiana | 47714-0805 | — |
| University of Iowa Hospitals and Clinics /ID# 215246 | Iowa City | Iowa | 52242 | — |
| The Center for Rheumatology and Bone Research /ID# 211610 | Wheaton | Maryland | 20902 | — |
| Beth Israel Deaconess Medical Center /ID# 212321 | Boston | Massachusetts | 02215-5400 | — |
| Henry Ford Health System /ID# 211676 | Detroit | Michigan | 48202 | — |
| June DO, PC /ID# 211674 | Lansing | Michigan | 48910 | — |
| West County Rheumatology /ID# 225051 | St Louis | Missouri | 63131-1703 | — |
| NYU Langone Ambulatory Care Brooklyn Heights /ID# 211548 | Brooklyn | New York | 11201 | — |
| NYU Langone Orthopedic Center /ID# 213620 | New York | New York | 10016-2772 | — |
| Ohio State University - Wexner Medical Center /ID# 211636 | Columbus | Ohio | 43210-1229 | — |
| STAT Research, Inc. /ID# 211404 | Vandalia | Ohio | 45377-9464 | — |
| Premier Rheumatology of Oklahoma /ID# 213850 | Tulsa | Oklahoma | 74136-2117 | — |
| Allegheny Health Network Research Institute /ID# 211607 | Pittsburgh | Pennsylvania | 15224 | — |
| Univ TN Health Sciences Ctr /ID# 212177 | Memphis | Tennessee | 38103 | — |
| Dr. Ramesh Gupta /ID# 213381 | Memphis | Tennessee | 38119 | — |
| Tekton Research, Inc. /ID# 211521 | Austin | Texas | 78745 | — |
| Tekton Research, Inc. /ID# 214182 | Austin | Texas | 78745 | — |
| Trinity Universal Research Associates - Carrollton /ID# 211527 | Carrollton | Texas | 75007 | — |
| Accurate Clinical Management /ID# 213571 | Houston | Texas | 77084 | — |
| West Texas Clinical Research /ID# 211529 | Lubbock | Texas | 79424 | — |
| SW Rheumatology Res. LLC /ID# 211520 | Mesquite | Texas | 75150 | — |
| Carilion Clinic /ID# 213500 | Roanoke | Virginia | 24016 | — |
| Virginia Mason Medical Center /ID# 211457 | Seattle | Washington | 98101 | — |
| Rheumatology and Pulmonary Clinic /ID# 211398 | Beckley | West Virginia | 25801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 113 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03978520, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 20, 2023 · Synced May 5, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03978520 live on ClinicalTrials.gov.