Testing the Addition of a New Anti-Cancer Drug, Niraparib, to the Usual Treatment (Hormone and Radiation Therapy) for Prostate Cancer With a High Chance of Recurring
Public ClinicalTrials.gov record NCT04037254. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized Phase II Trial of Niraparib With Standard Combination Radiotherapy and Androgen Deprivation Therapy (ADT) in High Risk Prostate Cancer (With Initial Phase I) (NADIR*) *Randomized Phase II Trial of Niraparib With Standard Combination Androgen DeprIvation Therapy (ADT) and Radiotherapy in High Risk Prostate Cancer (With Initial Phase I)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a phase I-II trial to find the safety and activity of adding a new drug (neraparib) to the usual treatment (radiation combined with male hormone deprivation therapy) in lowering the chance of prostate cancer growing or returning. Niraparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA) when it becomes damaged. Blocking PARP may help keep cancer cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy. Adding niraparib to the usual care may lower the chance of prostate cancer growing or returning.
Study identification
- NCT ID
- NCT04037254
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 22 participants
Conditions and interventions
Conditions
Interventions
- Gonadotrophin Releasing Hormone Biological
- Intensity-Modulated Radiation Therapy Radiation
- Niraparib Drug
Biological · Radiation · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 8, 2019 (Actual)
- Primary completion
- Jul 1, 2024 (Actual)
- Completion
- Dec 23, 2025 (Actual)
- Last update posted
- Jul 10, 2026
2019 – 2025
United States locations
- U.S. sites
- 94
- U.S. states
- 22
- U.S. cities
- 80
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | — |
| University of Arizona Cancer Center-Orange Grove Campus | Tucson | Arizona | 85704 | — |
| University of Arizona Cancer Center-North Campus | Tucson | Arizona | 85719 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Fremont - Rideout Cancer Center | Marysville | California | 95901 | — |
| University of California Davis Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| City of Hope Upland | Upland | California | 91786 | — |
| Helen F Graham Cancer Center | Newark | Delaware | 19713 | — |
| Medical Oncology Hematology Consultants PA | Newark | Delaware | 19713 | — |
| George Washington University Medical Center | Washington D.C. | District of Columbia | 20037 | — |
| Grady Health System | Atlanta | Georgia | 30303 | — |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Emory Saint Joseph's Hospital | Atlanta | Georgia | 30342 | — |
| CTCA at Southeastern Regional Medical Center | Newnan | Georgia | 30265 | — |
| Alton Memorial Hospital | Alton | Illinois | 62002 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Rush MD Anderson Cancer Center | Chicago | Illinois | 60612 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa | 52242 | — |
| University of Kansas Cancer Center | Kansas City | Kansas | 66160 | — |
| University of Kansas Cancer Center-Overland Park | Overland Park | Kansas | 66210 | — |
| University of Kansas Hospital-Westwood Cancer Center | Westwood | Kansas | 66205 | — |
| University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| Central Maryland Radiation Oncology in Howard County | Columbia | Maryland | 21044 | — |
| UM Baltimore Washington Medical Center/Tate Cancer Center | Glen Burnie | Maryland | 21061 | — |
| Massachusetts General Hospital Cancer Center | Boston | Massachusetts | 02114 | — |
| McLaren Cancer Institute-Bay City | Bay City | Michigan | 48706 | — |
| Henry Ford Cancer Institute-Downriver | Brownstown | Michigan | 48183 | — |
| McLaren Cancer Institute-Clarkston | Clarkston | Michigan | 48346 | — |
| Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Michigan | 48038 | — |
| Henry Ford Medical Center-Fairlane | Dearborn | Michigan | 48126 | — |
| Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Weisberg Cancer Treatment Center | Farmington Hills | Michigan | 48334 | — |
| McLaren Cancer Institute-Flint | Flint | Michigan | 48532 | — |
| Singh and Arora Hematology Oncology PC | Flint | Michigan | 48532 | — |
| Karmanos Cancer Institute at McLaren Greater Lansing | Lansing | Michigan | 48910 | — |
| Mid-Michigan Physicians-Lansing | Lansing | Michigan | 48912 | — |
| McLaren Cancer Institute-Lapeer Region | Lapeer | Michigan | 48446 | — |
| McLaren Cancer Institute-Macomb | Mount Clemens | Michigan | 48043 | — |
| Henry Ford Medical Center-Columbus | Novi | Michigan | 48377 | — |
| McLaren Cancer Institute-Northern Michigan | Petoskey | Michigan | 49770 | — |
| McLaren-Port Huron | Port Huron | Michigan | 48060 | — |
| Henry Ford Macomb Health Center - Shelby Township | Shelby | Michigan | 48315 | — |
| Henry Ford West Bloomfield Hospital | West Bloomfield | Michigan | 48322 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Siteman Cancer Center at Saint Peters Hospital | City of Saint Peters | Missouri | 63376 | — |
| Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | 63141 | — |
| University of Kansas Cancer Center - North | Kansas City | Missouri | 64154 | — |
| University of Kansas Cancer Center - Lee's Summit | Lee's Summit | Missouri | 64064 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Siteman Cancer Center-South County | St Louis | Missouri | 63129 | — |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| AtlantiCare Health Park-Cape May Court House | Cape May Court House | New Jersey | 08210 | — |
| AtlantiCare Surgery Center | Egg Harbor | New Jersey | 08234 | — |
| Rutgers New Jersey Medical School | Newark | New Jersey | 07101 | — |
| Holy Name Hospital | Teaneck | New Jersey | 07666 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| The New York Hospital Medical Center of Queens | Flushing | New York | 11355 | — |
| Highland Hospital | Rochester | New York | 14620 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Stony Brook University Medical Center | Stony Brook | New York | 11794 | — |
| Summa Health System - Akron Campus | Akron | Ohio | 44304 | — |
| Summa Health System - Barberton Campus | Barberton | Ohio | 44203 | — |
| University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | 45219 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Summa Health Medina Medical Center | Medina | Ohio | 44256 | — |
| University of Cincinnati Cancer Center-West Chester | West Chester | Ohio | 45069 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | 19317 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | — |
| Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | 17837 | — |
| Lewistown Hospital | Lewistown | Pennsylvania | 17044 | — |
| Eastern Regional Medical Center | Philadelphia | Pennsylvania | 19124 | — |
| University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC-Shadyside Hospital | Pittsburgh | Pennsylvania | 15232 | — |
| Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | 18711 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Prisma Health Cancer Institute - Faris | Greenville | South Carolina | 29605 | — |
| Saint Francis Cancer Center | Greenville | South Carolina | 29607 | — |
| Prisma Health Cancer Institute - Eastside | Greenville | South Carolina | 29615 | — |
| Self Regional Healthcare | Greenwood | South Carolina | 29646 | — |
| Prisma Health Cancer Institute - Greer | Greer | South Carolina | 29650 | — |
| Prisma Health Cancer Institute - Seneca | Seneca | South Carolina | 29672 | — |
| West Virginia University Healthcare | Morgantown | West Virginia | 26506 | — |
| Froedtert Menomonee Falls Hospital | Menomonee Falls | Wisconsin | 53051 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Zablocki Veterans Administration Medical Center | Milwaukee | Wisconsin | 53295 | — |
| Drexel Town Square Health Center | Oak Creek | Wisconsin | 53154 | — |
| ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | 53066 | — |
| UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | 53188 | — |
| Froedtert West Bend Hospital/Kraemer Cancer Center | West Bend | Wisconsin | 53095 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04037254, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 10, 2026 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04037254 live on ClinicalTrials.gov.