Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)
Public ClinicalTrials.gov record NCT04047628. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter Randomized Controlled Trial of Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Treatment-Resistant Relapsing Multiple Sclerosis (ITN077AI)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multi-center prospective rater-masked (blinded) randomized controlled trial of 156 participants, comparing the treatment strategy of Autologous Hematopoietic Stem Cell Transplantation (AHSCT) to the treatment strategy of Best Available Therapy (BAT) for treatment-resistant relapsing multiple sclerosis (MS). Participants will be randomized at a 1 to 1 (1:1) ratio. All participants will be followed for 72 months after randomization (Day 0, Visit 0).
Study identification
- NCT ID
- NCT04047628
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 156 participants
Conditions and interventions
Conditions
Interventions
- Autologous Hematopoietic Stem Cell Transplantation Procedure
- Best Available Therapy (BAT) Biological
Procedure · Biological
Eligibility (public fields only)
- Age range
- 18 Years to 55 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 17, 2020 (Actual)
- Primary completion
- Oct 2026 (Estimated)
- Completion
- Oct 2029 (Estimated)
- Last update posted
- Sep 16, 2026
2020 – 2029
United States locations
- U.S. sites
- 23
- U.S. states
- 16
- U.S. cities
- 21
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Stanford Multiple Sclerosis Center | Palo Alto | California | 94304 | Recruiting |
| Rocky Mountain Multiple Sclerosis Center, University of Colorado School of Medicine | Aurora | Colorado | 80045 | Recruiting |
| Northwestern University | Evanston | Illinois | 60208 | Recruiting |
| University of Massachusetts Memorial Medical Center | Worcester | Massachusetts | 01655 | Recruiting |
| Henry Ford Neuroscience Institute | Detroit | Michigan | 48202 | Recruiting |
| University of Minnesota Multiple Sclerosis Center | Minneapolis | Minnesota | 55455 | Active, not recruiting |
| Mayo Clinic | Rochester | Minnesota | 55905 | Recruiting |
| John L. Trotter Multiple Sclerosis Center, Washington University School of Medicine in St. Louis | St Louis | Missouri | 63110 | Recruiting |
| Corinne Goldsmith Dickinson Center for Multiple Sclerosis at Mount Siinai | New York | New York | 10029 | Recruiting |
| Rochester Multiple Sclerosis Center, University of Rochester | Rochester | New York | 14620 | Not yet recruiting |
| Duke University Medical Center | Durham | North Carolina | 27710 | Active, not recruiting |
| University of Cincinnati (UC) Waddell Center for Multiple Sclerosis | Cincinnati | Ohio | 45219 | Recruiting |
| Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic | Cleveland | Ohio | 44195 | Recruiting |
| Multiple Sclerosis Center, Oregon Health & Science University | Portland | Oregon | 97239 | Recruiting |
| Penn Comprehensive MS Center, Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | Recruiting |
| University of Texas Southwestern Medical Center: Division of Multiple Sclerosis and Neuroimmunology | Dallas | Texas | 75390 | Recruiting |
| Maxine Mesigner Multiple Sclerosis Comprehensive Care Center, Baylor College of Medicine Medical Center | Houston | Texas | 77030 | Recruiting |
| University of Virginia | Charlottesville | Virginia | 22903 | Recruiting |
| Virginia Commonwealth University Multiple Sclerosis Treatment and Research Center | Richmond | Virginia | 23219 | Recruiting |
| Clinical Research Division, Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109 | Active, not recruiting |
| Multiple Sclerosis Center, Swedish Neuroscience Institute | Seattle | Washington | 98122 | Recruiting |
| Multiple Sclerosis Center at Northwest Hospital | Seattle | Washington | 98133 | Recruiting |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04047628, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 16, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04047628 live on ClinicalTrials.gov.