First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia
Public ClinicalTrials.gov record NCT04067336. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1/2 First in Human Study of the Menin-MLL(KMT2A) Inhibitor KO-539 in Patients With Relapsed or Refractory Acute Myeloid Leukemia
Study identification
- NCT ID
- NCT04067336
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Kura Oncology, Inc.
- Industry
- Enrollment
- 263 participants
Conditions and interventions
Conditions
Interventions
- Itraconazole Drug
- Midazolam Drug
- Ziftomenib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 11, 2019
- Primary completion
- Oct 15, 2028
- Completion
- Oct 15, 2028
- Last update posted
- Apr 20, 2026
2019 – 2028
United States locations
- U.S. sites
- 23
- U.S. states
- 17
- U.S. cities
- 21
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | Recruiting |
| Mayo Clinic | Phoenix | Arizona | 85054 | Withdrawn |
| University of Southern California | Los Angeles | California | 90033 | Withdrawn |
| UCLA Ronald Reagan Medical Center | Los Angeles | California | 90095 | Recruiting |
| Mayo Clinic | Jacksonville | Florida | 32224 | Active, not recruiting |
| Robert H. Lurie Comprehensive Cancer Center of Northwestern University | Chicago | Illinois | 60611 | Recruiting |
| Indiana University Melvin and Bren Simon Comprehensive Cancer Center | Indianapolis | Indiana | 46202 | Withdrawn |
| University of Maryland Greenebaum Comprehensive Cancer Center | Baltimore | Maryland | 21201 | Active, not recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Recruiting |
| University of Michigan Hospitals | Ann Arbor | Michigan | 48109 | Active, not recruiting |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | Recruiting |
| Mayo Clinic | Rochester | Minnesota | 55905 | Completed |
| Hackensack University Medical Center - John Theurer Cancer Center | Hackensack | New Jersey | 07601 | Recruiting |
| Roswell Park Comprehensive Cancer Center | Buffalo | New York | 14203 | Recruiting |
| Weill Cornell Medical College - NY Presbyterian Hospital | New York | New York | 10021 | Completed |
| The Mount Sinai Hospital | New York | New York | 10029 | Recruiting |
| Duke Cancer Institute | Durham | North Carolina | 27710 | Completed |
| Oklahoma University Health - Stephenson Cancer Center | Oklahoma City | Oklahoma | 73117 | Recruiting |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | Recruiting |
| Vanderbilt-Ingram Cancer Center | Nashville | Tennessee | 37232 | Active, not recruiting |
| Harold C. Simmons Comprehensive Cancer Center - UT Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109 | Completed |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 33 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04067336, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 20, 2026 · Synced Apr 29, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04067336 live on ClinicalTrials.gov.