Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive to Hormonal Therapy

ClinicalTrials.gov ID: NCT04071236

Public ClinicalTrials.gov record NCT04071236. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:52 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase I and Randomized Phase II Trial of Radium-223 Dichloride, M3814, &Amp; Avelumab in Advanced Metastatic Castrate-Resistant Prostate Cancer (mCRPC)

Study identification

NCT ID: NCT04071236
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: National Cancer Institute (NCI); NIH
Enrollment: 90 participants

Conditions and interventions

Conditions

Interventions

Avelumab Drug
Biospecimen Collection Procedure
Bone Scan Procedure
Computed Tomography Procedure
Magnetic Resonance Imaging Procedure
Peposertib Drug
Questionnaire Administration Other
Radium Ra 223 Dichloride Radiation

Drug · Procedure · Other + 1 more

Eligibility (public fields only)

Age range: 18 Years and older
Sex: Male
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 13, 2020
Primary completion: Apr 29, 2027
Completion: Apr 29, 2027
Last update posted: Apr 28, 2026

2020 – 2027

United States locations

U.S. sites: 32
U.S. states: 14
U.S. cities: 27

Facility	City	State	ZIP	Site status
City of Hope Comprehensive Cancer Center	Duarte	California	91010	Recruiting
Los Angeles General Medical Center	Los Angeles	California	90033	Recruiting
USC / Norris Comprehensive Cancer Center	Los Angeles	California	90033	Active, not recruiting
UC Irvine Health/Chao Family Comprehensive Cancer Center	Orange	California	92868	Recruiting
University of California Davis Comprehensive Cancer Center	Sacramento	California	95817	Active, not recruiting
UM Sylvester Comprehensive Cancer Center at Aventura	Aventura	Florida	33180	Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables	Coral Gables	Florida	33146	Recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach	Deerfield Beach	Florida	33442	Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	33136	Recruiting
UM Sylvester Comprehensive Cancer Center at Kendall	Miami	Florida	33176	Recruiting
UM Sylvester Comprehensive Cancer Center at Plantation	Plantation	Florida	33324	Recruiting
Emory University Hospital Midtown	Atlanta	Georgia	30308	Active, not recruiting
Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	30322	Active, not recruiting
Emory Saint Joseph's Hospital	Atlanta	Georgia	30342	Active, not recruiting
University of Kansas Clinical Research Center	Fairway	Kansas	66205	Active, not recruiting
University of Kansas Cancer Center	Kansas City	Kansas	66160	Active, not recruiting
University of Kansas Cancer Center-Overland Park	Overland Park	Kansas	66210	Active, not recruiting
University of Kansas Hospital-Westwood Cancer Center	Westwood	Kansas	66205	Active, not recruiting
University of Kentucky/Markey Cancer Center	Lexington	Kentucky	40536	Recruiting
Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	48201	Suspended
Siteman Cancer Center at Saint Peters Hospital	City of Saint Peters	Missouri	63376	Recruiting
Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	63141	Recruiting
University of Kansas Cancer Center at North Kansas City Hospital	North Kansas City	Missouri	64116	Active, not recruiting
Washington University School of Medicine	St Louis	Missouri	63110	Recruiting
Siteman Cancer Center-South County	St Louis	Missouri	63129	Recruiting
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center	Lebanon	New Hampshire	03756	Active, not recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone	New York	New York	10016	Active, not recruiting
Ohio State University Comprehensive Cancer Center	Columbus	Ohio	43210	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	19107	Active, not recruiting
UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	75390	Suspended
Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	84112	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04071236, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 28, 2026 · Synced May 6, 2026

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The complete protocol, eligibility criteria, and contact information for NCT04071236 live on ClinicalTrials.gov.

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