Approaches and Decisions for Acute Pediatric TBI Trial
Public ClinicalTrials.gov record NCT04077411. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Approaches and Decisions for Acute Pediatric TBI (ADAPT) Trial
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Approaches and Decisions in Acute Pediatric TBI Trial (ADAPT) is an international research study designed to evaluate the impact of interventions on the outcomes of children with severe traumatic brain injury. Pediatric traumatic brain injury (TBI) is the leading killer of children, resulting in more than 7000 deaths and $2 billion in acute care costs each year. Despite this large burden of disease, advances in the field have been limited due to weak evidenced-based guidelines and the limitations of randomized, controlled trials (RCTs) to demonstrate efficacy of single treatment strategies due to wide treatment variability. ADAPT is a practical study design in a novel approach - an observational cohort study designed to evaluate the association of 6 aspects of pediatric TBI care with outcomes using statistical modeling to correct for confounding variables. Completion of this study will provide compelling evidence to change clinical practices, provide evidence for new Level II recommendations for future guidelines and lead to improved research protocols that would limit variability in TBI treatments - helping children immediately through better clinical practices and ultimately through more effective investigation.
Study identification
- NCT ID
- NCT04077411
- Recruitment status
- Completed
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 1,000 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- Up to 18 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 20, 2014 (Actual)
- Primary completion
- Sep 26, 2016 (Actual)
- Completion
- Aug 28, 2018 (Actual)
- Last update posted
- Dec 8, 2023
2014 – 2018
United States locations
- U.S. sites
- 30
- U.S. states
- 22
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Children's Hospital of Alabama | Birmingham | Alabama | 35294 | — |
| Phoenix Children's Hospital | Phoenix | Arizona | 85016 | — |
| University of California, San Diego / Rady's Children's Hospital | La Jolla | California | 92093 | — |
| Children's Hospital of Los Angeles | Los Angeles | California | 90027 | — |
| UCLA Mattel Children's Hospital | Los Angeles | California | 90095 | — |
| UC Davis Medical Center | West Sacramento | California | 95798 | — |
| Children's Hospital Colorado | Denver | Colorado | 80045 | — |
| Children's National Medical Center | Washington D.C. | District of Columbia | 20010 | — |
| Miami Children's Hospital | Miami | Florida | 33155 | — |
| Children's Healthcare of Atlanta | Atlanta | Georgia | 30322 | — |
| University of Iowa Children's Hospita | Iowa City | Iowa | 52252 | — |
| John Hopkins Children's Center of Baltimore | Baltimore | Maryland | 21287 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02241 | — |
| Boston Children's Hospital / Harvard University | Boston | Massachusetts | 414413 | — |
| Wayne State University in Detroit / Children's Hospital of Michigan | Detroit | Michigan | 13201 | — |
| Washington University - St. Louis | St Louis | Missouri | 63112 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Carolinas Medical Center Levine Children's Hospital | Charlotte | North Carolina | 28260 | — |
| University of Cincinnati / Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | 45229 | — |
| Nationwide Children's Hospital | Columbus | Ohio | 43271 | — |
| Penn State University - Hershey | Hershey | Pennsylvania | 17033 | — |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19178 | — |
| Children's Hospital of Pittsburgh of UPMC | Pittsburgh | Pennsylvania | 15213 | — |
| University of Tennessee / Le Bonheur Children's Hospita | Memphis | Tennessee | 38163 | — |
| UT Southwestern / Children's Medical Center at Dallas | Dallas | Texas | 75284 | — |
| Texas Children's Hospital (Baylor College of Medicine) | Houston | Texas | 77030 | — |
| Primary Children's Hospital | Salt Lake City | Utah | 84113 | — |
| Children's Hospital of Richmond at VCU | Richmond | Virginia | 23298 | — |
| University of Washington - Seattle | Seattle | Washington | 98185 | — |
| University of Wisconsin - Madison | Madison | Wisconsin | 53715 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 18 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04077411, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 8, 2023 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04077411 live on ClinicalTrials.gov.