Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders
Public ClinicalTrials.gov record NCT04079179. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Study to Assess the Safety and Efficacy of Cobimetinib in Refractory Langerhans Cell Histiocytosis, LCH-Associated Neurodegenerative Disease, and Other Histiocytic Disorders.
Study identification
- NCT ID
- NCT04079179
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Carl Allen
- Other
- Enrollment
- 90 participants
Conditions and interventions
Conditions
Interventions
- Cobimetinib Drug
Drug
Eligibility (public fields only)
- Age range
- Not listed
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 18, 2021
- Primary completion
- Nov 30, 2025
- Completion
- Nov 30, 2029
- Last update posted
- Sep 17, 2025
2021 – 2029
United States locations
- U.S. sites
- 12
- U.S. states
- 10
- U.S. cities
- 12
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Phoenix Children's Hospital | Phoenix | Arizona | 85016 | Recruiting |
| Arkansas Children's Hospital | Little Rock | Arkansas | 72202 | Recruiting |
| Children's Hospital of Orange County | Orange | California | 92868 | Recruiting |
| UCSF Benioff Children's Hospital | San Francisco | California | 94158 | Recruiting |
| Children's National Hospital | Washington D.C. | District of Columbia | 20010 | Recruiting |
| John Hopkins University School of Medicine | Baltimore | Maryland | 21287 | Recruiting |
| Dana Farber Cancer Institute, Boston Children's | Boston | Massachusetts | 02215 | Recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Recruiting |
| NACHO Consortium | Memphis | Tennessee | 38105 | Not yet recruiting |
| Children's Medical Center- UTSW | Dallas | Texas | 75235 | Recruiting |
| Texas Children's Hospital | Houston | Texas | 77030 | Recruiting |
| University of Wisconsin-American Family Children's Hospital | Madison | Wisconsin | 53792 | Terminated |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04079179, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 17, 2025 · Synced May 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04079179 live on ClinicalTrials.gov.