A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

ClinicalTrials.gov ID: NCT04094610

Public ClinicalTrials.gov record NCT04094610. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 7, 2026, 12:11 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1/2, Open-Label, Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity Study of Repotrectinib in Pediatric and Young Adult Subjects With Advanced or Metastatic Malignancies Harboring ALK, ROS1, NTRK1-3 Alterations

Study identification

NCT ID: NCT04094610
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Turning Point Therapeutics, Inc.; Industry
Enrollment: 75 participants

Conditions and interventions

Conditions

Interventions

Oral repotrectinib (TPX-0005) Drug

Drug

Eligibility (public fields only)

Age range: Up to 25 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 11, 2020
Primary completion: Sep 29, 2026
Completion: Sep 29, 2027
Last update posted: Nov 18, 2025

2020 – 2027

United States locations

U.S. sites: 20
U.S. states: 15
U.S. cities: 17

Facility	City	State	ZIP	Site status
Children's Hospital Los Angeles	Los Angeles	California	90027-6062	Recruiting
University of California at Los Angeles	Los Angeles	California	90095	Recruiting
Children's Hospital Colorado - Anschutz Medical Campus	Aurora	Colorado	80045	Recruiting
Local Institution - 2105	Orlando	Florida	32806	Completed
Local Institution - 2120	Orlando	Florida	32827	Completed
Children's Healthcare of Atlanta - Egleston Hospital	Atlanta	Georgia	30329	Recruiting
Maine Medical Center	Scarborough	Maine	04074	Recruiting
Dana Farber Cancer Institute.	Boston	Massachusetts	02215	Recruiting
Washington University School of Medicine in St. Louis	St Louis	Missouri	63110	Recruiting
Local Institution - 2110	New Brunswick	New Jersey	08901	Completed
Local Institution - 2102	New York	New York	10065	Completed
Levine Children's Hospital- Pediatric Neuro-Oncology	Charlotte	North Carolina	28203	Recruiting
Local Institution - 2112	Cleveland	Ohio	44195	Completed
Local Institution - 2114	Hershey	Pennsylvania	17033	Completed
Children's Hospital of Philadelphia-Center for Childhood Cancer Research	Philadelphia	Pennsylvania	19104	Recruiting
St. Jude Children's Research Hospital	Memphis	Tennessee	38015	Recruiting
The University of Texas Southwestern Medical Center - Harold C Simmons Comprehensive Cancer Center	Dallas	Texas	75390	Recruiting
Baylor College of Medicine	Houston	Texas	77030	Recruiting
Local Institution - 2104	Houston	Texas	77030	Completed
Children's Hospital of Richmond at VCU	Richmond	Virginia	23219	Withdrawn

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 48 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04094610, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Nov 18, 2025 · Synced May 7, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04094610 live on ClinicalTrials.gov.

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