Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) Trial
Public ClinicalTrials.gov record NCT04095663. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The COSMID (Comparison of Surgery and Medicine on the Impact of Diverticulitis) trial is a pragmatic, patient-level randomized superiority trial of elective colectomy vs. best medical management for patients with quality of life (QoL) limiting diverticular disease. A parallel observational cohort will include those who are disinclined to have their treatment choice randomized, but are willing to contribute information about their outcomes. The goal of the COSMID trial is to answer the question: For patients with QoL-limiting diverticular disease, is elective colectomy more effective than best medical management? The hypothesis being tested in the COSMID trial is that patient-reported outcomes (PROs) among patients in the surgery arm will be superior to those in the best medical management arm.
Study identification
- NCT ID
- NCT04095663
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 255 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 1, 2019 (Actual)
- Primary completion
- Feb 1, 2027 (Estimated)
- Completion
- Feb 1, 2027 (Estimated)
- Last update posted
- Feb 19, 2026
2019 – 2027
United States locations
- U.S. sites
- 29
- U.S. states
- 16
- U.S. cities
- 27
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| UC San Diego Health | San Diego | California | 92103 | — |
| UCSF Health | San Francisco | California | 94143 | — |
| Stanford University Medical Center | Stanford | California | 94305 | — |
| University of Colorado | Denver | Colorado | 80045 | — |
| University of Florida | Gainesville | Florida | 32608 | — |
| University of South Florida | Tampa | Florida | 33606 | — |
| Memorial Health University Medical Center | Savannah | Georgia | 31404 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Northwestern University | Evanston | Illinois | 60201 | — |
| University of Iowa Healthcare | Iowa City | Iowa | 52242 | — |
| Boston University Medical Center | Boston | Massachusetts | 02118 | — |
| Lahey Clinic | Burlington | Massachusetts | 01805 | — |
| Albany Medical College | Albany | New York | 12208 | — |
| New York Presbyterian-Queens | Flushing | New York | 11355 | — |
| Columbia University Medical Center | New York | New York | 10027 | — |
| Weill Cornell Medicine | New York | New York | 10065 | — |
| University of Rochester Medical Center | Rochester | New York | 14618 | — |
| Atrium Health-Carolinas Medical Center | Charlotte | North Carolina | 28203 | — |
| Mount Carmel Health Systems | Columbus | Ohio | 43213 | — |
| Penn Medicine | Philadelphia | Pennsylvania | 19104 | — |
| Allegheny-Singer Research Institute | Pittsburgh | Pennsylvania | 15212 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | — |
| UTHealth Houston | Houston | Texas | 77026 | — |
| University of Utah Health | Salt Lake City | Utah | 84112 | — |
| VCU Medical Center | Richmond | Virginia | 23298 | — |
| Benaroya Research Institute at Virginia Mason | Seattle | Washington | 98101 | — |
| University of Washington | Seattle | Washington | 98105 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04095663, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 19, 2026 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04095663 live on ClinicalTrials.gov.