Safety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced Malignancies
Public ClinicalTrials.gov record NCT04137900. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A First-in-Human, Multicenter, Open-Label, Phase 1 Dose-Escalation and Cohort Expansion Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TAB004 as Monotherapy and in Combination With Toripalimabin Subjects With Advanced Solid Malignancies Including Lymphoma
Study identification
- NCT ID
- NCT04137900
- Recruitment status
- Not listed
- Study type
- Interventional
- Phase
- Phase 1
- Lead sponsor
- TopAlliance Biosciences
- Industry
- Enrollment
- 499 participants
Conditions and interventions
Interventions
- TAB004 Drug
- Toripalimab Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 29, 2019
- Primary completion
- Feb 28, 2026
- Completion
- Feb 28, 2026
- Last update posted
- Feb 4, 2024
2019 – 2026
United States locations
- U.S. sites
- 24
- U.S. states
- 18
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | Recruiting |
| University of Arizona College of Medicine-Tucson | Tucson | Arizona | 85721 | Recruiting |
| UCLA Health Westwood Cancer Care | Los Angeles | California | 90095 | Recruiting |
| University of California Irvine (UCI) Medical Center | Orange | California | 92868 | Recruiting |
| University of California San Francisco (UCSF) Medical Center-Mission Bay | San Francisco | California | 22902 | Recruiting |
| University of California at San Francisio | San Francisco | California | 94158 | Recruiting |
| Boca Raton Clinical Research (BRCR) | Boca Raton | Florida | 33432 | Withdrawn |
| Winship Cancer Institute at Emory University | Atlanta | Georgia | 30322 | Recruiting |
| University of Iowa Hospitals | Iowa City | Iowa | 52242 | Recruiting |
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Recruiting |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | Recruiting |
| Washington University | St Louis | Missouri | 63110 | Recruiting |
| University of Nebraska Medical Center | Omaha | Nebraska | 68105 | Suspended |
| Northwell Health | New Hyde Park | New York | 11042 | Not yet recruiting |
| New York Presbyterian / Weill Cornell Medical Center | New York | New York | 10021 | Active, not recruiting |
| Carolina BioOncology Institute | Huntersville | North Carolina | 28078 | Active, not recruiting |
| UC Health - University of Cincinnati Medical Center | Cincinnati | Ohio | 45219 | Suspended |
| The Ohio State University Wexner Medical Center The James Cancer Hospital and Solove Research Institute | Columbus | Ohio | 43210 | Recruiting |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | Recruiting |
| Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | Active, not recruiting |
| University of Texas Southwestern Medical Center Harold C. Simmons Comprehensive Cancer Center | Dallas | Texas | 75390-8565 | Recruiting |
| MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| University of Wisconsin | Madison | Wisconsin | 53792 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04137900, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 4, 2024 · Synced May 12, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04137900 live on ClinicalTrials.gov.