Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors

ClinicalTrials.gov ID: NCT04165772

Public ClinicalTrials.gov record NCT04165772. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 5:03 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase II Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors

Study identification

NCT ID: NCT04165772
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Enrollment: 200 participants

Conditions and interventions

Conditions

Interventions

Intensity Modulated Radiation Therapy (IMRT) Radiation
TSR-042 or Dostarlimab Drug
capecitabine or 5-FU Drug

Radiation · Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 10, 2019
Primary completion: Nov 29, 2026
Completion: Nov 29, 2026
Last update posted: Jan 22, 2026

2019 – 2026

United States locations

U.S. sites: 10
U.S. states: 5
U.S. cities: 10

Facility	City	State	ZIP	Site status
Hartford Healthcare (Data Collection)	Hartford	Connecticut	06102	Recruiting
Baptist Alliance MCI (Data Collection Only)	Miami	Florida	33143	Recruiting
Memorial Sloan Kettering Basking Ridge - Limited Protocol Activities	Basking Ridge	New Jersey	07920	Recruiting
Memorial Sloan Kettering Monmouth - Limited Protocol Activities	Middletown	New Jersey	07748	Recruiting
Memorial Sloan Kettering Bergen - Limited Protocol Activities	Montvale	New Jersey	07645	Recruiting
Memorial Sloan Kettering Commack - Limited Protocol Activities	Commack	New York	11725	Recruiting
Memorial Sloan Kettering Westchester - Limited Protocol Activities	Harrison	New York	10604	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
Memorial Sloan Kettering Nassau - Limited Protocol Activities	Uniondale	New York	11553	Recruiting
Lehigh Valley Health Network (Data Collection Only)	Allentown	Pennsylvania	18103	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04165772, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jan 22, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04165772 live on ClinicalTrials.gov.

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