A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis

ClinicalTrials.gov ID: NCT04176198

Public ClinicalTrials.gov record NCT04176198. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:41 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1/2, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of Oral Nuvisertib (TP-3654) in Patients With Intermediate or High-Risk Primary or Secondary Myelofibrosis

Study identification

NCT ID: NCT04176198
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Sumitomo Pharma America, Inc.; Industry
Enrollment: 240 participants

Conditions and interventions

Conditions

Myelofibrosis

Interventions

Momelotinib Drug
Nusivertib Drug
Ruxolitinib Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 15, 2019
Primary completion: Apr 29, 2027
Completion: Apr 29, 2030
Last update posted: Apr 30, 2026

2019 – 2030

United States locations

U.S. sites: 32
U.S. states: 23
U.S. cities: 28

Facility	City	State	ZIP	Site status
University of Alabama	Birmingham	Alabama	35294	Recruiting
The University of Arizona Cancer Center	Tucson	Arizona	85724	Recruiting
City of Hope	Duarte	California	91010	Recruiting
University of Southern California	Los Angeles	California	90033	Recruiting
Hoag Family Cancer Institute	Newport Beach	California	92663	Recruiting
Blood Cancer Center	Denver	Colorado	80218	Recruiting
Yale School of Medicine	New Haven	Connecticut	06510	Recruiting
University of Florida Health Shands Cancer Hospital	Gainesville	Florida	32608	Completed
University of Miami	Miami	Florida	33136	Recruiting
Baptist Health - Miami Cancer Institute	Miami	Florida	33176	Recruiting
Emory University	Atlanta	Georgia	30322	Recruiting
University of Chicago	Chicago	Illinois	60637	Recruiting
University of Maryland	Baltimore	Maryland	21201	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
University of Michigan	Ann Arbor	Michigan	48109	Recruiting
University of Minnesota	Minneapolis	Minnesota	55455	Recruiting
Washington University of Medicine	St Louis	Missouri	63110	Recruiting
John Theurer Cancer Center at Hackensack University Medical Center	Hackensack	New Jersey	07601	Recruiting
Roswell Park Comprehensive Cancer Center	Buffalo	New York	14263	Completed
Icahn School of Medicine at Mount Sinai	New York	New York	10029	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
Weill Cornell Medical Center	New York	New York	10065	Recruiting
Montefiore Cancer Center	The Bronx	New York	10461	Recruiting
Duke Cancer Institute	Durham	North Carolina	27710	Recruiting
Ohio State University	Columbus	Ohio	43210	Recruiting
Medical University of South Carolina	Charleston	South Carolina	29425	Recruiting
Tri-Star Centennial Medical Center	Nashville	Tennessee	37203	Recruiting
Vanderbilt University	Nashville	Tennessee	37232	Recruiting
MD Anderson Cancer Center	Houston	Texas	77054	Recruiting
Huntsman Cancer Institute	Salt Lake City	Utah	84112	Recruiting
University of Virginia Cancer Center	Charlottesville	Virginia	22903	Recruiting
University of Washington - Fred Hutchinson Cancer Center	Seattle	Washington	98109	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 52 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04176198, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 30, 2026 · Synced May 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04176198 live on ClinicalTrials.gov.

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