A Study of Ipatasertib in Combination With Atezolizumab and Paclitaxel as a Treatment for Participants With Locally Advanced or Metastatic Triple-Negative Breast Cancer
Public ClinicalTrials.gov record NCT04177108. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Double-blind, Placebo-controlled, Randomized Study of Ipatasertib in Combination With Atezolizumab and Paclitaxel as a Treatment for Patients With Locally Advanced Unresectable or Metastatic Triple-Negative Breast Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study evaluated the efficacy and safety of ipatasertib in combination with atezolizumab and paclitaxel in locally advanced or metastatic Triple-Negative Breast Cancer (TNBC) previously untreated in this setting.
Study identification
- NCT ID
- NCT04177108
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 242 participants
Conditions and interventions
Conditions
Interventions
- Atezolizumab Drug
- Ipatasertib Drug
- Paclitaxel Drug
- Placebo for Atezolizumab Drug
- Placebo for Ipatasertib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 25, 2019 (Actual)
- Primary completion
- Feb 28, 2023 (Actual)
- Completion
- Feb 28, 2023 (Actual)
- Last update posted
- Mar 27, 2024
2019 – 2023
United States locations
- U.S. sites
- 31
- U.S. states
- 19
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| USA Mitchell Cancer Institute | Mobile | Alabama | 36688 | — |
| Highlands Oncology Group | Springdale | Arkansas | 72762 | — |
| UCLA | Los Angeles | California | 90095 | — |
| Kaiser Permanente-SCPMG; Oncology Research | San Diego | California | 92108 | — |
| Stanford Cancer Center | Stanford | California | 94305-5820 | — |
| Kaiser Permanente - Franklin | Denver | Colorado | 80205 | — |
| Stamford Hospital; BCC, MOHR | Stamford | Connecticut | 06904 | — |
| Holy Cross Hospital | Fort Lauderdale | Florida | 33308 | — |
| Memorial Healthcare System - Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| Memorial Cancer Institute at Memorial West | Pembroke Pines | Florida | 33028 | — |
| Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Nancy N. and J.C. Lewis Cancer & Research Pavillion -St. Josephs / Candler Health System-CCD PRIME | Savannah | Georgia | 31405 | — |
| Rush University | Chicago | Illinois | 60612 | — |
| Ochsner Clinic Foundation | Baton Rouge | Louisiana | 70809 | — |
| Ochsner Health System | New Orleans | Louisiana | 70121 | — |
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| Mercy Medical Center | Baltimore | Maryland | 21202 | — |
| Medstar Franklin Square Medical Center | Baltimore | Maryland | 21237 | — |
| St. Joseph Mercy Hospital; Cancer Care Center. | Ann Arbor | Michigan | 48106 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Jackson Oncology Associates, PLLC | Jackson | Mississippi | 39202 | — |
| CHI Health Saint Francis; Oncology | Grand Island | Nebraska | 68803 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Hackensack Univ Med Ctr | Hackensack | New Jersey | 07601 | — |
| Wake Forest University Baptist Medical Center | Winston-Salem | North Carolina | 27157 | — |
| Kaiser Permanente - Portland | Portland | Oregon | 97227 | — |
| Oregon Health and Science University | Portland | Oregon | 97229 | — |
| Charleston Oncology, P .A | Charleston | South Carolina | 29414 | — |
| Greenville Health System; Cancer Center | Greenville | South Carolina | 29605-4292 | — |
| The West Clinic; West Cancer Center | Germantown | Tennessee | 38138 | — |
| Vanderbilt Univ Medical Ctr | Nashville | Tennessee | 37203 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 151 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04177108, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 27, 2024 · Synced Oct 26, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04177108 live on ClinicalTrials.gov.