Safety and Efficacy of Lenvatinib (E7080/MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma (MK-7902-012/E7080-G000-318/LEAP-012)
Public ClinicalTrials.gov record NCT04246177. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Multicenter, Randomized, Double-blinded, Active-controlled, Clinical Study to Evaluate the Safety and Efficacy of Lenvatinib (E7080/MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) Versus TACE in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma (LEAP-012)
Study identification
- NCT ID
- NCT04246177
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Merck Sharp & Dohme LLC
- Industry
- Enrollment
- 479 participants
Conditions and interventions
Conditions
Interventions
- IV Placebo Drug
- Lenvatinib Drug
- Oral Placebo Drug
- Pembrolizumab Biological
- TACE Procedure
Drug · Biological · Procedure
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 21, 2020
- Primary completion
- Aug 18, 2025
- Completion
- Mar 25, 2026
- Last update posted
- May 13, 2026
2020 – 2026
United States locations
- U.S. sites
- 27
- U.S. states
- 20
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Oncology Associates PC- HOPE ( Site 0770) | Tucson | Arizona | 85711 | — |
| Scripps Clinic Torrey Pines ( Site 0714) | La Jolla | California | 92037 | — |
| USC Norris Comprehensive Cancer Center ( Site 0717) | Los Angeles | California | 90033 | — |
| UCLA Hematology/Oncology - Santa Monica ( Site 0720) | Los Angeles | California | 90404 | — |
| UC Irvine Health ( Site 0718) | Orange | California | 92868 | — |
| Yale Cancer Center ( Site 0724) | New Haven | Connecticut | 06510 | — |
| Tampa General Hospital ( Site 0764) | Tampa | Florida | 33606 | — |
| Mountain States Tumor Institute ( Site 0773) | Boise | Idaho | 83712 | — |
| University of Iowa Hospital and Clinics ( Site 0729) | Iowa City | Iowa | 52242 | — |
| University of Kansas Cancer Center ( Site 0731) | Westwood | Kansas | 66205 | — |
| University of Louisville ( Site 0757) | Louisville | Kentucky | 40202 | — |
| Tulane Medical Center ( Site 0787) | New Orleans | Louisiana | 70112 | — |
| University Medical Center New Orleans ( Site 0733) | New Orleans | Louisiana | 70112 | — |
| Henry Ford Hospital-GI/Hepatology Research ( Site 0735) | Detroit | Michigan | 48202 | — |
| Saint Louis University ( Site 0769) | St Louis | Missouri | 63110 | — |
| University of New Mexico Comprehensive Cancer Center ( Site 0805) | Albuquerque | New Mexico | 87106 | — |
| Monter Cancer Center ( Site 0780) | Lake Success | New York | 11042 | — |
| Icahn School of Medicine at Mount Sinai ( Site 0744) | New York | New York | 10029 | — |
| Wake Forest Baptist Health ( Site 0741) | Winston-Salem | North Carolina | 27157 | — |
| University of Cincinnati Medical Center ( Site 0791) | Cincinnati | Ohio | 45219 | — |
| The Ohio State University Wexner Medical Center ( Site 0759) | Columbus | Ohio | 43210 | — |
| ProMedica Flower Hospital ( Site 0796) | Sylvania | Ohio | 43560 | — |
| Stephenson Cancer Center ( Site 0745) | Oklahoma City | Oklahoma | 73104 | — |
| OHSU Center for Health & Healing ( Site 0746) | Portland | Oregon | 97239 | — |
| Penn State Hershey Medical Center ( Site 0766) | Hershey | Pennsylvania | 17033-0850 | — |
| Houston Methodist Research Institute ( Site 0784) | Houston | Texas | 77030 | — |
| Edwards Comprehensive Cancer Center ( Site 0786) | Huntington | West Virginia | 25701 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 178 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04246177, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 13, 2026 · Synced May 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04246177 live on ClinicalTrials.gov.