ClinicalTrials.gov record
KEAPSAKE: A Study of Telaglenastat (CB-839) With Standard-of-Care Chemoimmunotherapy in 1L KEAP1/NRF2-Mutated, Nonsquamous NSCLC
ClinicalTrials.gov ID: NCT04265534
Public ClinicalTrials.gov record NCT04265534. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced Apr 25, 2026, 7:51 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Randomized, Multicenter, Double-Blind Study of the Glutaminase Inhibitor Telaglenastat With Pembrolizumab and Chemotherapy Versus Placebo With Pembrolizumab and Chemotherapy in First-Line, Metastatic KEAP1/NRF2-Mutated, Nonsquamous, Non-Small Cell Lung Cancer (NSCLC)
Study identification
- NCT ID
- NCT04265534
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Calithera Biosciences, Inc
- Industry
- Enrollment
- 40 participants
Conditions and interventions
Conditions
Interventions
- Carboplatin Chemotherapy Drug
- Dexamethasone 4 mg Drug
- Folic acid 400 -1000 μg Dietary Supplement
- Pembrolizumab Immunotherapy Biological
- Pemetrexed Chemotherapy Drug
- Placebo Drug
- Telaglenastat Drug
- Vitamin B12 1000 μg Dietary Supplement
Drug · Dietary Supplement · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 23, 2020
- Primary completion
- Nov 4, 2021
- Completion
- Feb 8, 2022
- Last update posted
- Sep 20, 2022
2020 – 2022
United States locations
- U.S. sites
- 102
- U.S. states
- 34
- U.S. cities
- 89
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| University of South Alabama - Mitchell Cancer Center | Mobile | Alabama | 36604 | — |
| Yuma Regional Medical Center | Yuma | Arizona | 85364 | — |
| Compassionate Cancer Care | Fountain Valley | California | 92708 | — |
| St. Joseph Heritage Healthcare | Fullerton | California | 92835 | — |
| Loma Linda University Medical Center | Loma Linda | California | 92350 | — |
| University of Southern California (USC) | Los Angeles | California | 90033 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| UCLA | Los Angeles | California | 90095 | — |
| University of California Irvine, Chao Family Comprehensive Cancer Center | Orange | California | 92868 | — |
| St. Joseph Heritage Healthcare - Santa Rosa | Santa Rosa | California | 95403 | — |
| Johns Hopkins Sibley Memorial Hospital | Washington D.C. | District of Columbia | 20016 | — |
| Sibley Memorial Hospital | Washington D.C. | District of Columbia | 20016 | — |
| Boca Raton Regional Hospital Lynn Cancer Institute | Boca Raton | Florida | 33486 | — |
| Holy Cross Hospital - Bines Cancer Center | Fort Lauderdale | Florida | 33308 | — |
| Florida Cancer Specialist - South (SCRI) | Fort Myers | Florida | 33901 | — |
| Memorial Cancer Institute at Memorial Hospital West | Hollywood | Florida | 33021 | — |
| University of Miami Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | — |
| Ocala Oncology Center | Ocala | Florida | 34474 | — |
| Florida Cancer Specialist - North (SCRI) | St. Petersburg | Florida | 33705 | — |
| Florida Cancer Specialist - Panhandle (SCRI) | Tallahassee | Florida | 32308 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Florida Cancer Specialist - East (SCRI) | West Palm Beach | Florida | 33401 | — |
| University Cancer and Blood Center | Athens | Georgia | 30607 | — |
| Piedmont Cancer Institute | Atlanta | Georgia | 30318 | — |
| Emory University Hospital | Atlanta | Georgia | 30322 | — |
| Northwest Georgia Oncology | Marietta | Georgia | 30060 | — |
| Hawaii Cancer Care | Honolulu | Hawaii | 96813 | — |
| Oncology of Northshore | Rolling Meadows | Illinois | 60008 | — |
| Orchard Healthcare Research Inc. | Skokie | Illinois | 60077 | — |
| Fort Wayne Medical Oncology and Hematology | Fort Wayne | Indiana | 46804 | — |
| Beacon Health | South Bend | Indiana | 46601 | — |
| University of Kansas Medical Center (KUMC) | Westwood | Kansas | 66205 | — |
| Pontchartrain Cancer Center | Covington | Louisiana | 70443 | — |
| Johns Hopkins Bayview Memorial Hospital | Baltimore | Maryland | 21224 | — |
| Center for Cancer and Blood Disorders | Bethesda | Maryland | 20817 | — |
| Maryland Oncology Hematology - USOR | Columbia | Maryland | 21044 | — |
| Frederick Health - James M. Stockman Cancer Institute | Frederick | Maryland | 21702 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Henry Ford Cancer Institute | Detroit | Michigan | 48202 | — |
| Bronson Methodist Hospital (West Michigan Cancer Center) | Kalamazoo | Michigan | 49001 | — |
| St. Joseph Mercy Hospital Cancer Care Center | Ypsilanti | Michigan | 48197 | — |
| Minnesota Oncology Hematology, P.A. | Coon Rapids | Minnesota | 55433 | — |
| Minnesota Oncology Hematology, P.A. | Edina | Minnesota | 55435 | — |
| Minnesota Oncology Hematology, P.A. | Maplewood | Minnesota | 55109 | — |
| Minnesota Oncology Hematology, P.A. | Minneapolis | Minnesota | 55404 | — |
| Minnesota Oncology Hematology, P.A. | Saint Paul | Minnesota | 55102 | — |
| Minnesota Oncology Hematology, P.A. | Woodbury | Minnesota | 55125 | — |
| Central Care Cancer Center | Bolivar | Missouri | 65613 | — |
| Washington University | St Louis | Missouri | 63110 | — |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68114 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89169 | — |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03766 | — |
| New Jersey Cancer Care and Blood Disorders (NJCCBD) | Belleville | New Jersey | 07109 | — |
| Summit Medical Group | Berkeley Heights | New Jersey | 07932 | — |
| The Valley Hospital - Luckow Pavilion | Paramus | New Jersey | 07652 | — |
| University of New Mexico Comprehensive Cancer Center | Albuquerque | New Mexico | 87131 | — |
| New York Oncology Hematology, P.C. (400 Patoon Creek Blvd.) | Albany | New York | 12206 | — |
| New York Oncology Hematology, P.C. (43 New Scotland Ave.) | Albany | New York | 12208 | — |
| Roswell Park Comprehensive Cancer Center | Buffalo | New York | 14263 | — |
| New York Oncology Hematology, P.C. | Clifton Park | New York | 12065 | — |
| Pelmutter Cancer Center at Winthrop | Mineola | New York | 11501 | — |
| New York University Langone (NYU) | New York | New York | 10016 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| Weill Cornell Medical College - New York Presbyterian Hospital | New York | New York | 10065 | — |
| Cone Health at Alamance Regional | Burlington | North Carolina | 27215 | — |
| Cone Health Cancer Center | Greensboro | North Carolina | 27403 | — |
| Aultman Hospital | Canton | Ohio | 44710 | — |
| TriHealth Cancer Institute | Cincinnati | Ohio | 45220 | — |
| Ohio State University, James Cancer Hospital and Solove Research Institute | Columbus | Ohio | 43210 | — |
| Ohio Health | Columbus | Ohio | 43214 | — |
| Toledo Clinic Cancer Center | Toledo | Ohio | 43623 | — |
| Oklahoma Cancer Specialists and Research Institute (OCSRI) | Tulsa | Oklahoma | 74146 | — |
| Providence Portland Medical Center | Portland | Oregon | 92713 | — |
| Oregon Health & Science University (OHSU) Knight Cancer Institute | Portland | Oregon | 97239 | — |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| Pennsylvania State University Milton S. Hershey Medical Center | State College | Pennsylvania | 16801 | — |
| Sanford Health | Sioux Falls | South Dakota | 57104 | — |
| Tennessee Oncology - Chattanooga (SCRI) | Chattanooga | Tennessee | 37404 | — |
| Tennessee Oncology - Nashville (SCRI) | Nashville | Tennessee | 37203 | — |
| Texas Oncology - Austin Midtown | Austin | Texas | 78705 | — |
| Texas Oncology - Austin Central | Austin | Texas | 78731 | — |
| Texas Oncology - South Austin | Austin | Texas | 78745 | — |
| Texas Oncology Beaumont - USOR | Beaumont | Texas | 77701 | — |
| Texas Oncology - Denison | Denison | Texas | 75020 | — |
| Texas Oncology - Fort Worth Cancer Center | Fort Worth | Texas | 76104 | — |
| Oncology Consultants | Houston | Texas | 770390 | — |
| Oncology and Hematology of South Texas | Laredo | Texas | 78041 | — |
| Utah Cancer Specialist | Salt Lake City | Utah | 84106 | — |
| University of Utah - Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | — |
| Oncology and Hematology Associates of Southwest Virginia | Blacksburg | Virginia | 24060 | — |
| Virginia Cancer Specialists | Fairfax | Virginia | 22031 | — |
| Oncology and Hematology Associates of Southwest Virginia | Low Moor | Virginia | 24457 | — |
| Virginia Commonwealth University (VCU) Massey Cancer Center | Richmond | Virginia | 23298 | — |
| Oncology and Hematology Associates of Southwest Virginia | Roanoke | Virginia | 24014 | — |
| Oncology and Hematology Associates of Southwest Virginia | Salem | Virginia | 24153 | — |
| Oncology and Hematology Associates of Southwest Virginia | Wytheville | Virginia | 24382 | — |
| University of Washington Seattle Cancer Care Alliance (SCCA) | Seattle | Washington | 98109 | — |
| Northwest Medical Specialities | Tacoma | Washington | 98405 | — |
| University of Wisconsin Carbone Cancer Center | Madison | Wisconsin | 53705 | — |
| Froedtert Hospital and the Medical College of Wisconsin (MCW) | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04265534, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 20, 2022 · Synced Apr 25, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04265534 live on ClinicalTrials.gov.