A Study to Evaluate Efficacy and Safety of Macitentan 75 mg in Inoperable or Persistent/Recurrent Chronic Thromboembolic Pulmonary Hypertension
Public ClinicalTrials.gov record NCT04271475. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Prospective, Randomized, Double-blind, Multicenter, Placebo-controlled, Parallel Group, Adaptive Phase 3 Study With Open-label Extension to Evaluate Efficacy and Safety of Macitentan 75 mg in Inoperable or Persistent/Recurrent Chronic Thromboembolic Pulmonary Hypertension
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the study is to evaluate the effect of macitentan 75 mg versus placebo on exercise capacity at Week 28 in participants with chronic thromboembolic pulmonary hypertension (CTEPH).
Study identification
- NCT ID
- NCT04271475
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 127 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 7, 2020 (Actual)
- Primary completion
- Dec 21, 2023 (Actual)
- Completion
- Dec 21, 2023 (Actual)
- Last update posted
- Jun 27, 2025
2020 – 2023
United States locations
- U.S. sites
- 24
- U.S. states
- 20
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of California San Diego Medical Center | La Jolla | California | 92037 | — |
| Keck School of Medicine of USC | Los Angeles | California | 90033 | — |
| UC Davis Medical Center | Sacramento | California | 95817-2201 | — |
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
| Yale University School Of Medicine | New Haven | Connecticut | 06519 | — |
| University of Florida Health Jacksonville | Gainesville | Florida | 32608 | — |
| Piedmont Healthcare | Atlanta | Georgia | 30309 | — |
| Northwestern University Feinberg School of Medicine | Chicago | Illinois | 60611 | — |
| Indiana University | Indianapolis | Indiana | 46202 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| University of Maryland | Baltimore | Maryland | 21201 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Tufts Medical Center | Boston | Massachusetts | 21118 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198-2265 | — |
| VA Sierra Nevada Health Care System | Reno | Nevada | 89509 | — |
| University of New Mexico School of Medicine | Albuquerque | New Mexico | 87131 | — |
| Syracuse VA Medical Center | Syracuse | New York | 13210 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Legacy Hospital | Portland | Oregon | 97210 | — |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15213 | — |
| Baylor Scott White - Plano | Plano | Texas | 75093 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| University of Utah Cardiovascular Center | Salt Lake City | Utah | 84132 | — |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792-2442 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 144 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04271475, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 27, 2025 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04271475 live on ClinicalTrials.gov.