Study of Efficacy and Safety of Brolucizumab Versus Panretinal Photocoagulation Laser in Patients With Proliferative Diabetic Retinopathy
Public ClinicalTrials.gov record NCT04278417. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 96-week, Two-arm, Randomized, Single-masked, Multi-center, Phase III Study Assessing the Efficacy and Safety of Brolucizumab 6 mg Compared to Panretinal Photocoagulation Laser in Patients With Proliferative Diabetic Retinopathy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study was to evaluate the efficacy and safety of brolucizumab compared to panretinal photocoagulation laser (PRP) in patients with proliferative diabetic retinopathy (PDR). This evaluation will provide information that brolucizumab is non-inferior to PRP with respect to the change in best corrected visual acuity at Week 54.
Study identification
- NCT ID
- NCT04278417
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 689 participants
Conditions and interventions
Conditions
Interventions
- Brolucizumab 6 mg Biological
- Panretinal photocoagulation laser Procedure
Biological · Procedure
Eligibility (public fields only)
- Age range
- 18 Years to 100 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 19, 2020 (Actual)
- Primary completion
- Oct 30, 2023 (Actual)
- Completion
- Aug 19, 2024 (Actual)
- Last update posted
- Oct 16, 2025
2020 – 2024
United States locations
- U.S. sites
- 40
- U.S. states
- 16
- U.S. cities
- 35
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retina Associates SW | Tucson | Arizona | 85704 | — |
| Retina- Vitreous Assoc Medical Group | Beverly Hills | California | 90211 | — |
| Retina Consultants of Orange County | Fullerton | California | 92835 | — |
| Salehi Retina Institute | Huntington Beach | California | 92647 | — |
| Retina Consultants of Southern California | Redlands | California | 92374 | — |
| Premiere Practice Management LLC | Torrance | California | 90505 | — |
| Lundquist Inst BioMed at Harbor | Torrance | California | 90509-2910 | — |
| Miramar Eye Specialists | Ventura | California | 93003 | — |
| Advanced Research LLC | Deerfield Beach | Florida | 33064 | — |
| Rand Eye Institute | Deerfield Beach | Florida | 33064 | — |
| Pinnacle Research Institute | Fort Lauderdale | Florida | 33309 | — |
| National Ophthalmic Research Institute | Fort Myers | Florida | 33912-7125 | — |
| Florida Retina Institute | Jacksonville | Florida | 32216 | — |
| Blue Oc Clin Res at Palm Bch Eye Ct | Lakeland | Florida | 33801 | — |
| MedEye Associates | Miami | Florida | 33143 | — |
| Florida Retina Institute | Orlando | Florida | 32804 | — |
| Eye Center of North Florida | Panama City | Florida | 32405 | — |
| Fort Lauderdale Eye Institute | Plantation | Florida | 33324 | — |
| Retina Associates | Elmhurst | Illinois | 60126 | — |
| Midwest Eye Institute | Indianapolis | Indiana | 46280 | — |
| John-Kenyon American Eye Institute PC | New Albany | Indiana | 47150 | — |
| Retina Associates PA | Lenexa | Kansas | 66215 | — |
| Cumberland Valley Retina Consultants | Hagerstown | Maryland | 21740 | — |
| University of Mississippi Med Ctr | Jackson | Mississippi | 39216 | — |
| Retina Associates Of Cleveland | Cleveland | Ohio | 44122 | — |
| Dean McGee Eye Institute | Oklahoma City | Oklahoma | 73104 | — |
| Cascade Medical Research Institute | Springfield | Oregon | 97477 | — |
| Erie Retinal Surgery | Erie | Pennsylvania | 16507 | — |
| Charleston Neuroscience Institute | Ladson | South Carolina | 29456 | — |
| Southeastern Retina Associates P C | Knoxville | Tennessee | 37923 | — |
| Austin Retina Associates | Austin | Texas | 78705 | — |
| Texan Eye P A | Austin | Texas | 78731 | — |
| Retina And Vitreous Of Texas | Bellaire | Texas | 77401 | — |
| Retina Consultants TX Rsrch Ctr | Bellaire | Texas | 77401 | — |
| Texas Retina Associates | Fort Worth | Texas | 76104 | — |
| Valley Retina Institute PA | Harlingen | Texas | 78550 | — |
| Retina Consultants of Houston PA | Houston | Texas | 77030 | — |
| Medical Center Opthamology Assoc | San Antonio | Texas | 78240 | — |
| Retina Associates Of South Texas PA | San Antonio | Texas | 78240 | — |
| Virginia Eye Consultants | Norfolk | Virginia | 23502 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 80 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04278417, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 16, 2025 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04278417 live on ClinicalTrials.gov.