Efficacy and Safety Study of IV Ravulizumab in Patients With COVID-19 Severe Pneumonia
Public ClinicalTrials.gov record NCT04369469. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared With Best Supportive Care in Patients With COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study evaluated the efficacy, safety, pharmacokinetics, and pharmacodynamics of ravulizumab administered in adult participants with coronavirus disease 2019 (COVID-19) severe pneumonia, acute lung injury, or acute respiratory distress syndrome. Participants were randomly assigned to receive ravulizumab in addition to best supportive care (BSC) (2/3 of the participants) or BSC alone (1/3 of the participants). BSC consisted of medical treatment and/or medical interventions per routine hospital practice.
Study identification
- NCT ID
- NCT04369469
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 202 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 10, 2020 (Actual)
- Primary completion
- Feb 8, 2021 (Actual)
- Completion
- Apr 8, 2021 (Actual)
- Last update posted
- May 24, 2022
2020 – 2021
United States locations
- U.S. sites
- 24
- U.S. states
- 16
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Central Arkansas Veterans Healthcare System | Little Rock | Arkansas | 72205 | — |
| LAC/USC Health Center | Los Angeles | California | 90033 | — |
| UC Irvine Medical Center | Orange | California | 92868 | — |
| MedStar Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| University of Florida | Jacksonville | Florida | 32209 | — |
| Mayo Clinic Florida | Jacksonville | Florida | 32224 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Norton Healthcare | Louisville | Kentucky | 40241 | — |
| Baltimore VA Medical Center | Baltimore | Maryland | 21201 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Mayo Clinic Health System | Mankato | Minnesota | 56001 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| NYU Langone Health Center | New York | New York | 10016 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| Westchester Medical Center | Valhalla | New York | 10595 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Baptist Memorial Hospital | Memphis | Tennessee | 38120 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| Mayo Clinic Health System in Eau Claire | Eau Claire | Wisconsin | 54703 | — |
| Mayo Clinic Health System | La Crosse | Wisconsin | 54601 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 15 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04369469, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 24, 2022 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04369469 live on ClinicalTrials.gov.