A Study to Evaluate the Safety, Tolerability, and Efficacy of Long-Term Gantenerumab Administration in Participants With Alzheimer's Disease (AD)
Public ClinicalTrials.gov record NCT04374253. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-Label, Multicenter, Rollover Study to Evaluate the Safety, Tolerability, and Efficacy of Long-Term Gantenerumab Administration in Participants With Alzheimer's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is an open-label, multicenter, rollover study to evaluate the safety, tolerability, and efficacy of long-term administration of open-label gantenerumab in participants with AD who completed Study WN29922 or WN39658, either the double-blind or open-label extension (OLE) part.
Study identification
- NCT ID
- NCT04374253
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,382 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- Not listed
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 26, 2021 (Actual)
- Primary completion
- Mar 6, 2023 (Actual)
- Completion
- Mar 6, 2023 (Actual)
- Last update posted
- May 8, 2024
2021 – 2023
United States locations
- U.S. sites
- 67
- U.S. states
- 25
- U.S. cities
- 61
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner Alzheimer?s Institute | Phoenix | Arizona | 85006 | — |
| Barrow Neurological Institute | Phoenix | Arizona | 85013 | — |
| Banner Sun Health Research Insitute | Sun City | Arizona | 85351 | — |
| Health Initiatives Research, PLLC | Fayetteville | Arkansas | 72703 | — |
| Fullerton Neurology and Headache Center | Fullerton | California | 92835 | — |
| Neurology Center of North Orange County | Fullerton | California | 92835 | — |
| Irvine Center for Clinical Research | Irvine | California | 92614 | — |
| Desert Valley Research | Redlands | California | 92374 | — |
| Sutter Medical Group, Neurology | Sacramento | California | 95816 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| California Neuroscience Research Medical Group, Inc | Sherman Oaks | California | 91403 | — |
| Southern California Research LLC | Simi Valley | California | 93065 | — |
| Yale University School Of Medicine | New Haven | Connecticut | 06519 | — |
| Research Center for Clinical Studies, Inc. | Norwalk | Connecticut | 06851 | — |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | — |
| JEM Research LLC | Atlantis | Florida | 33462 | — |
| Accel Research Sites - CRU Tampa | Bradenton | Florida | 34201 | — |
| Bradenton Research Center | Bradenton | Florida | 34205 | — |
| Brain Matters Research, Inc. | Delray Beach | Florida | 33445 | — |
| ClinCloud, LLC | Maitland | Florida | 32751 | — |
| Optimus U Corp | Miami | Florida | 33125 | — |
| Allied Biomedical Research Institute, Inc | Miami | Florida | 33155 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| Intercoastal Medical Group | Sarasota | Florida | 34239 | — |
| Infinity Clinical Research, LLC | Sunrise | Florida | 33351 | — |
| Axiom Clinical Research of Florida | Tampa | Florida | 33609 | — |
| Alzheimer?s Research and Treatment Center | Wellington | Florida | 33414 | — |
| Emory University | Atlanta | Georgia | 30329 | — |
| Center for Advanced Research & Education | Gainesville | Georgia | 30501 | — |
| Southern Illinois University, School of Medicine | Springfield | Illinois | 62702 | — |
| American Health Network Institute, LLC | Avon | Indiana | 46123 | — |
| Fort Wayne Neurological Center | Fort Wayne | Indiana | 46805 | — |
| Via Christi Research | Wichita | Kansas | 67214 | — |
| Brigham and Womens Hospital; Center for Alzheimer Research & Treatment | Boston | Massachusetts | 02115 | — |
| Boston Center for Memory | Newton | Massachusetts | 02459 | — |
| Precise Research Centers | Flowood | Mississippi | 39232 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Missouri Memory Center | Bolivar | Missouri | 65613 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| University of Nebraska Medical Center; Dept of Neurological Sciences | Omaha | Nebraska | 68198-8440 | — |
| Cleveland Clinic Lou Ruvo; Center for Brain Research | Las Vegas | Nevada | 89106 | — |
| The Cognitive and Research Center of New Jersey | Springfield | New Jersey | 07081 | — |
| Advanced Memory Research Institute of NJ | Toms River | New Jersey | 08755 | — |
| Neurological Associates of Long Island, PC | Lake Success | New York | 11042 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| AD-CARE, University of Rochester Medical Center | Rochester | New York | 14620 | — |
| Richmond Behavioral Associates | Staten Island | New York | 10314 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| Behavioral Health Research | Charlotte | North Carolina | 28211 | — |
| Alzheimer's Memory Center | Matthews | North Carolina | 28105 | — |
| Raleigh Neurology Associates | Raleigh | North Carolina | 27607-6520 | — |
| Wake Forest University | Winston-Salem | North Carolina | 27157 | — |
| Cleveland Clinic; Cleveland Lou Ruvo Center for Brain Health ? Neurological Institute | Cleveland | Ohio | 44195 | — |
| Ohio State University; College of Medicine | Columbus | Ohio | 43210 | — |
| Summit Research Network Inc. | Portland | Oregon | 97210 | — |
| Abington Neurological Associates | Abington | Pennsylvania | 19001 | — |
| The Clinical Trial Center, LLC | Jenkintown | Pennsylvania | 19046 | — |
| Senior Adults Specialty Research | Austin | Texas | 78757 | — |
| Kerwin Medical Center | Dallas | Texas | 75231 | — |
| Neurology Consultants of Dallas; Research Department | Dallas | Texas | 75243 | — |
| Alzheimers Disease & Memory Disorders Center; Department of Neurology Baylor College of Medicine | Houston | Texas | 77030 | — |
| The University of Texas Health Science Center at Houston | Houston | Texas | 77054 | — |
| Wasatch Clinical Research, LLC | Salt Lake City | Utah | 84107 | — |
| University of Virginia | Charlottesville | Virginia | 22906 | — |
| Sentara Neurology Specialists | Norfolk | Virginia | 23507 | — |
| National Clinical Research Inc.-Richmond | Richmond | Virginia | 23294 | — |
| UW Wisconsin-Madison | Madison | Wisconsin | 53705 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 201 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04374253, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 8, 2024 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04374253 live on ClinicalTrials.gov.