A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder
Public ClinicalTrials.gov record NCT04375033. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
CSP #2014 - Comparative Effectiveness of Two Formulations of Buprenorphine for Treating Opioid Use Disorder in Veterans (VA-BRAVE)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
VA-BRAVE will determine whether a 28-day long-acting injectable sub-cutaneous formulation of buprenorphine at a target dose of 300mg is superior in retaining Veterans in opioid treatment and in sustaining opioid abstinence compared to the daily sublingual (under the tongue) buprenorphine formulation at a target dose of 4-32 mg (standard of care). This is an open-label, randomized, controlled trial including 952 Veterans with opioid use disorder (OUD) recruited over 7 years and followed actively for 52 weeks. There are a number of secondary objectives that will be studied as well and include: comorbid substance use, both non-fatal and fatal opioid overdose, HIV and Hepatitis B (HBV) and C (HCV) testing results and risk behaviors, incarceration, quality of life, psychiatric symptoms of depression and posttraumatic stress disorder, housing status, dental health and utilization, and cost-effectiveness.
Study identification
- NCT ID
- NCT04375033
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 952 participants
Conditions and interventions
Conditions
Interventions
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 2, 2020
- Primary completion
- Sep 29, 2028
- Completion
- May 30, 2029
- Last update posted
- Jan 11, 2026
2020 – 2029
United States locations
- U.S. sites
- 25
- U.S. states
- 18
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Tuscaloosa VA Medical Center, Tuscaloosa, AL | Tuscaloosa | Alabama | 35404-5015 | Terminated |
| Phoenix VA Health Care System, Phoenix, AZ | Phoenix | Arizona | 85012 | Recruiting |
| VA Long Beach Healthcare System, Long Beach, CA | Long Beach | California | 90822 | Recruiting |
| VA Palo Alto Health Care System, Palo Alto, CA | Palo Alto | California | 94304-1207 | Recruiting |
| San Francisco VA Medical Center, San Francisco, CA | San Francisco | California | 94121-1563 | Recruiting |
| CERC (VISN1, West Haven, CT) | West Haven | Connecticut | 06516-2770 | Recruiting |
| VA Connecticut Healthcare System West Haven Campus, West Haven, CT | West Haven | Connecticut | 06516-2770 | Active, not recruiting |
| Wilmington VA Medical Center, Wilmington, DE | Wilmington | Delaware | 19805-4917 | Recruiting |
| Bay Pines VA Healthcare System, Pay Pines, FL | Bay Pines | Florida | 33744-0000 | Recruiting |
| North Florida/South Georgia Veterans Health System, Gainesville, FL | Gainesville | Florida | 32608-1135 | Recruiting |
| VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA | Boston | Massachusetts | 02130 | Terminated |
| Minneapolis VA Health Care System, Minneapolis, MN | Minneapolis | Minnesota | 55417-2309 | Terminated |
| Louis Stokes VA Medical Center, Cleveland, OH | Cleveland | Ohio | 44106 | Terminated |
| Dayton VA Medical Center, Dayton, OH | Dayton | Ohio | 45428 | Recruiting |
| Philadelphia MultiService Center, Philadelphia, PA | Philadelphia | Pennsylvania | 19106 | Recruiting |
| VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA | Pittsburgh | Pennsylvania | 15240 | Terminated |
| Providence VA Medical Center, Providence, RI | Providence | Rhode Island | 02908-4734 | Terminated |
| VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX | Dallas | Texas | 75216-7167 | Recruiting |
| VA Salt Lake City Health Care System, Salt Lake City, UT | Salt Lake City | Utah | 84148-0001 | Recruiting |
| White River Junction VA Medical Center, White River Junction, VT | White River Junction | Vermont | 05001-3833 | Terminated |
| Hampton VA Medical Center, Hampton, VA | Hampton | Virginia | 23667 | Recruiting |
| Salem VA Medical Center, Salem, VA | Salem | Virginia | 24153-6404 | Recruiting |
| VA Puget Sound Health Care System Seattle Division, Seattle, WA | Seattle | Washington | 98108-1532 | Recruiting |
| Huntington VA Medical Center, Huntington, WV | Huntington | West Virginia | 25704-9300 | Not yet recruiting |
| Clement J. Zablocki VA Medical Center, Milwaukee, WI | Milwaukee | Wisconsin | 53295-0001 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04375033, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 11, 2026 · Synced Sep 4, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04375033 live on ClinicalTrials.gov.