Osimertinib Alone or With Chemotherapy for EGFR-Mutant Lung Cancers
Public ClinicalTrials.gov record NCT04410796. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Randomized Study of Osimertinib Versus Osimertinib Plus Chemotherapy for Patients With Metastatic EGFR-Mutant Lung Cancers That Have Detectable EGFR-Mutant cfDNA in Plasma After Initiation of Osimertinib
Study identification
- NCT ID
- NCT04410796
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Memorial Sloan Kettering Cancer Center
- Other
- Enrollment
- 571 participants
Conditions and interventions
Conditions
Interventions
- Carboplatin Drug
- Osimertinib Drug
- Pemetrexed Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 27, 2020
- Primary completion
- Apr 30, 2026
- Completion
- Apr 30, 2026
- Last update posted
- Nov 5, 2025
2020 – 2026
United States locations
- U.S. sites
- 18
- U.S. states
- 9
- U.S. cities
- 16
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UC Davis Cancer Center (Data Collection Only) | Sacramento | California | 95817 | Recruiting |
| University of California San Francisco | San Francisco | California | 94143 | Active, not recruiting |
| Moffitt Cancer Center | Tampa | Florida | 33612 | Recruiting |
| John Hopkins Medical Center | Baltimore | Maryland | 21287 | Recruiting |
| Massachusetts General Hospital (Data Collection Only) | Boston | Massachusetts | 02114 | Recruiting |
| Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities) | Basking Ridge | New Jersey | 07920 | Recruiting |
| Hackensack Meridian Health | Hackensack | New Jersey | 07601 | Recruiting |
| Memorial Sloan Kettering Monmouth (Limited Protocol Activities) | Middletown | New Jersey | 07748 | Recruiting |
| Memorial Sloan Kettering Bergen (Limited Protocol Activities) | Montvale | New Jersey | 07645 | Recruiting |
| Memorial Sloan Kettering Commack (Limited protocol activities) | Commack | New York | 11725 | Recruiting |
| Memorial Sloan Kettering Westchester (Limited protocol activities) | Harrison | New York | 10604 | Recruiting |
| New York University | New York | New York | 10010 | Recruiting |
| Columbia University (Data Collection Only) | New York | New York | 10032 | Active, not recruiting |
| Memorial Sloan Kettering Cancer Center (All protocol activities) | New York | New York | 10065 | Recruiting |
| Memorial Sloan Kettering Nassau (Limited Protocol Activities) | Uniondale | New York | 11553 | Recruiting |
| Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | Recruiting |
| MD ANDERSON CANCER CENTER (Data Collection Only) | Houston | Texas | 77030 | Recruiting |
| University of Washington (Data Collection Only) | Seattle | Washington | 98109 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04410796, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 5, 2025 · Synced May 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04410796 live on ClinicalTrials.gov.