A Study of Rituximab-Gemcitabine-Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma
Public ClinicalTrials.gov record NCT04442022. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2/3, Multicenter Randomized Study of Rituximab-Gemcitabine-Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma (RR DLBCL)
Study identification
- NCT ID
- NCT04442022
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Lead sponsor
- Karyopharm Therapeutics Inc
- Industry
- Enrollment
- 501 participants
Conditions and interventions
Interventions
- Cisplatin (combination therapy) Drug
- Dexamethasone (combination therapy) Drug
- Gemcitabine (combination therapy) Drug
- Placebo matching for Selinexor (combination therapy) Drug
- Placebo matching for Selinexor (continuous therapy) Drug
- Rituximab (combination therapy) Drug
- Selinexor (combination therapy) Drug
- Selinexor (continuous therapy) Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2, 2020
- Primary completion
- Nov 30, 2026
- Completion
- Nov 30, 2026
- Last update posted
- May 5, 2026
2020 – 2026
United States locations
- U.S. sites
- 8
- U.S. states
- 6
- U.S. cities
- 7
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers | Chandler | Arizona | 85224 | — |
| Arizona Oncology Associates | Tucson | Arizona | 85711 | — |
| The Oncology Institute (TOI) Clinical Research | Cerritos | California | 90703 | — |
| Norton Cancer Institute, St. Matthews | Louisville | Kentucky | 40207 | — |
| University of Maryland Greenebaum Comprehensive Cancer Center | Baltimore | Maryland | 21201 | — |
| Stony Brook | Stony Brook | New York | 11794 | — |
| Texas Oncology - Tyler | Tyler | Texas | 75702 | — |
| The University of Texas Health Science Center at Tyler DBA UT Health East Texas HOPE Cancer Center | Tyler | Texas | 75702 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 30 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04442022, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 5, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04442022 live on ClinicalTrials.gov.