A Ph2b to Evaluate Clinical Efficacy and Safety of Tildacerfont in Adult CAH
Public ClinicalTrials.gov record NCT04457336. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of SPR001 (Tildacerfont) in Adult Subjects With Classic Congenital Adrenal Hyperplasia
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
An investigation of the efficacy and safety of up to 70 weeks of treatment with Tildacerfont in subjects with classic CAH who have elevated biomarkers at baseline on their current GC regimen. Optional open label treatment extension period up to 240 weeks with 200mg Tildacerfont QD.
Study identification
- NCT ID
- NCT04457336
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 96 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 26, 2020 (Actual)
- Primary completion
- Feb 9, 2024 (Actual)
- Completion
- May 23, 2024 (Actual)
- Last update posted
- Jul 8, 2025
2020 – 2024
United States locations
- U.S. sites
- 28
- U.S. states
- 17
- U.S. cities
- 27
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Spruce Study Site | Birmingham | Alabama | 35294 | — |
| Spruce Study Site | Los Angeles | California | 90027 | — |
| Spruce Clinical Site | Orange | California | 92868 | — |
| Spruce Study Site | Sacramento | California | 95817 | — |
| Spruce Study Site | Englewood | Colorado | 80113 | — |
| Spruce Clinical Site | Tampa | Florida | 33612 | — |
| Spruce Study Site | West Palm Beach | Florida | 33401 | — |
| Spruce Study Site | Chicago | Illinois | 60611 | — |
| Spruce Clinical Site | Indianapolis | Indiana | 46202 | — |
| Spruce Study Site | Baltimore | Maryland | 21287 | — |
| Spruce Clinical Site | Minneapolis | Minnesota | 55454 | — |
| Spruce Study Site | Rochester | Minnesota | 55905 | — |
| Spruce Clinical Site | Las Vegas | Nevada | 89148 | — |
| Spruce Study Site | Hickory | North Carolina | 28601 | — |
| Spruce Study Site | Canton | Ohio | 44718 | — |
| Spruce Study Site | Cincinnati | Ohio | 45219 | — |
| Spruce Study Site | Cleveland | Ohio | 44195 | — |
| Spruce Study Site | Columbus | Ohio | 43210 | — |
| Spruce Clinical Site | Bend | Oregon | 97702 | — |
| Spruce Study Site | Philadelphia | Pennsylvania | 19104 | — |
| Spruce Study Site | Philadelphia | Pennsylvania | 19107 | — |
| Spruce Study Site | Providence | Rhode Island | 02903 | — |
| Spruce Study Site | Columbia | South Carolina | 28203 | — |
| Spruce Clinical Site | Memphis | Tennessee | 38163 | — |
| Spruce Study Site | Austin | Texas | 78731 | — |
| Spruce Study Site | Dallas | Texas | 75093 | — |
| Spruce Clinical Site | Edinburg | Texas | 78539 | — |
| Spruce Clinical Site | Fort Worth | Texas | 76104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 37 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04457336, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 8, 2025 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04457336 live on ClinicalTrials.gov.