A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome

ClinicalTrials.gov ID: NCT04462770

Public ClinicalTrials.gov record NCT04462770. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 20, 2026, 10:24 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A 20-Week Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of EPX-100 (Clemizole Hydrochloride) as Adjunctive Therapy in Children and Adult Participants With Dravet Syndrome (ARGUS Trial)

Study identification

NCT ID: NCT04462770
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Epygenix; Industry
Enrollment: 150 participants

Conditions and interventions

Conditions

Dravet Syndrome

Interventions

Clemizole HCl Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 2 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 14, 2020
Primary completion: Mar 31, 2027
Completion: Apr 30, 2029
Last update posted: May 13, 2026

2020 – 2029

United States locations

U.S. sites: 31
U.S. states: 21
U.S. cities: 30

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham	Birmingham	Alabama	35233	Active, not recruiting
Arkansas Children's Hospital	Little Rock	Arkansas	72202	Active, not recruiting
Children's Hospital of Los Angeles	Los Angeles	California	90027	Terminated
University of California Irvine	Orange	California	92868	Recruiting
UCSF Medical Center	San Francisco	California	94158	Recruiting
Yale University School of Medicine	New Haven	Connecticut	06510	Not yet recruiting
The Nemours Foundation	Wilmington	Delaware	19803	Terminated
Rare Disease Research FL	Kissimmee	Florida	34746	Recruiting
Pediatric Neurology and Epilepsy Specialists	Winter Park	Florida	32789	Recruiting
Clinical Integrative Research Center of Atlanta (CIRCA)	Atlanta	Georgia	30328	Withdrawn
Ann & Robert H. Lurie Children's Hospital of Chicago	Chicago	Illinois	60611	Terminated
Norton Children's Research Institute	Louisville	Kentucky	40202	Recruiting
University of Michigan- Mott Children's Hospital	Ann Arbor	Michigan	48109	Terminated
Children's Nebraska	Omaha	Nebraska	68114	Recruiting
Northeast Regional Epilepsy Group	Hackensack	New Jersey	07601	Terminated
Neurology Center for Epilepsy and Seizures	Marlboro	New Jersey	07746	Active, not recruiting
Weill Cornell Medical Center	New York	New York	10021	Recruiting
Northwell Health - Lenox Hill Hospital	New York	New York	10075	Not yet recruiting
Duke University Health System	Durham	North Carolina	27710	Recruiting
Science 37	Morrisville	North Carolina	27560	Active, not recruiting
Wake Forest Baptist Medical Center	Winston-Salem	North Carolina	27157	Recruiting
Cincinnati Children's Hospital Medical Center	Cincinnati	Ohio	45229	Recruiting
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting
Nationwide Children's Hospital	Columbus	Ohio	43205	Withdrawn
The Children's Hospital of Philadelphia	Philadelphia	Pennsylvania	19104	Recruiting
Le Bonheur Children's Hospital	Memphis	Tennessee	38103	Terminated
Child Neurology Consultants of Austin	Austin	Texas	78757	Recruiting
UT Southwestern/Children's Health	Dallas	Texas	75207	Withdrawn
University of Utah	Salt Lake City	Utah	84112	Recruiting
Seattle Children's Hospital	Seattle	Washington	98105	Recruiting
Medical College of Wisconsin, Children's Wisconsin	Milwaukee	Wisconsin	53266	Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 27 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04462770, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 13, 2026 · Synced May 20, 2026

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The complete protocol, eligibility criteria, and contact information for NCT04462770 live on ClinicalTrials.gov.

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