ClinicalTrials.gov record
A Study of NGM621 in Participants With Geographic Atrophy
ClinicalTrials.gov ID: NCT04465955
Public ClinicalTrials.gov record NCT04465955. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 13, 2026, 7:32 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Multicenter, Randomized, Double-Masked, Sham-Controlled Study of the Safety and Efficacy of Intravitreal Injections of NGM621 in Subjects With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)
Study identification
- NCT ID
- NCT04465955
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- NGM Biopharmaceuticals, Inc
- Industry
- Enrollment
- 320 participants
Conditions and interventions
Conditions
Interventions
- NGM621 Biological
- Sham Comparator Other
Biological · Other
Eligibility (public fields only)
- Age range
- 55 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 21, 2020
- Primary completion
- Aug 15, 2022
- Completion
- Aug 15, 2022
- Last update posted
- Jun 30, 2025
2020 – 2022
United States locations
- U.S. sites
- 65
- U.S. states
- 25
- U.S. cities
- 62
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Associated Retina Consultants | Phoenix | Arizona | 85020 | — |
| California Retina Consultants | Bakersfield | California | 93309 | — |
| Retina Vitreous Associates | Beverly Hills | California | 90211 | — |
| Retinal Diagnostic Center | Campbell | California | 95008 | — |
| The Retina Partners | Encino | California | 91436 | — |
| Retina Consultants of Orange County | Fullerton | California | 92835 | — |
| Loma Linda University Health | Loma Linda | California | 92354 | — |
| University of California Los Angeles | Los Angeles | California | 90095 | — |
| Northern California Retina Vitreous Associates | Mountain View | California | 94040 | — |
| Retina Institute of California | Palm Desert | California | 92260 | — |
| California Eye Specialists | Pasadena | California | 91107 | — |
| Retina Consultants San Diego | Poway | California | 92064 | — |
| Retinal Consultants Medical Group Inc | Sacramento | California | 95841 | — |
| University of California San Francisco | San Francisco | California | 94143 | — |
| Orange County Retina Medical Group | Santa Ana | California | 92705 | — |
| California Retina Consultants | Santa Barbara | California | 93103 | — |
| Retina Consultants of Southern Colorado PC | Colorado Springs | Colorado | 80909 | — |
| Colorado Retina Associates PC | Golden | Colorado | 80401 | — |
| New England Retina Associates PC | Waterford | Connecticut | 06385 | — |
| Florida Eye Microsurgical Institute | Boynton Beach | Florida | 33426 | — |
| University of Miami | Coral Gables | Florida | 33146 | — |
| Specialty Retina Center (Coral Springs) | Coral Springs | Florida | 33067 | — |
| Retina Group of Florida | Fort Lauderdale | Florida | 33308 | — |
| National Ophthalmic Research Institute | Fort Myers | Florida | 33912 | — |
| Florida Eye Associates | Melbourne | Florida | 32901 | — |
| Retina Specialty Institute | Pensacola | Florida | 32503 | — |
| Southern Vitreoretinal Associates | Tallahassee | Florida | 32308 | — |
| Retina Vitreous Associates of Florida | Tampa | Florida | 33607 | — |
| Georgia Retina PC | Marietta | Georgia | 30060 | — |
| Gailey Eye Clinic - Bloomington | Bloomington | Illinois | 61704 | — |
| University of Illinois | Chicago | Illinois | 60612 | — |
| University Retina and Macula Associates, PC | Lemont | Illinois | 60439 | — |
| Raj K. Maturi, MD, PC | Indianapolis | Indiana | 46290 | — |
| Retina Associates, PA | Shawnee Mission | Kansas | 66204 | — |
| Thompson Sjaarda, PA | Baltimore | Maryland | 21204 | — |
| Elman Retina Group PA | Baltimore | Maryland | 21237 | — |
| Ophthalmic Consultants of Boston | Boston | Massachusetts | 02114 | — |
| Associated Retina Consultants PC | Royal Oak | Michigan | 48073 | — |
| Associated Retina Consultants PC | Traverse City | Michigan | 49686 | — |
| Vitreoretinal Surgery PA | Minneapolis | Minnesota | 55435 | — |
| Deep Blue Retina Clinical Research | Southaven | Mississippi | 38671 | — |
| Sierra Eye Associates | Reno | Nevada | 89502 | — |
| Long Island Vitreoretinal Consultants | Great Neck | New York | 11021 | — |
| Vitreous Retina Macula Consultants of NY | New York | New York | 10022 | — |
| Albany Troy Cataract & Laser Associates | Troy | New York | 12180 | — |
| Western Carolina Retinal Associates | Asheville | North Carolina | 18803 | — |
| Southeast Clinical Research | Charlotte | North Carolina | 28210 | — |
| Duke University | Durham | North Carolina | 27705 | — |
| Sterling Research Group, Ltd. | Cincinnati | Ohio | 45219 | — |
| Retina Associates of Cleveland | Cleveland | Ohio | 44122 | — |
| The Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Cascade Medical Research Institute | Springfield | Oregon | 97477 | — |
| Eye Care Specialists | Kingston | Pennsylvania | 18704 | — |
| Retinovitreous Associates | Philadelphia | Pennsylvania | 19107 | — |
| Black Hills Regional Eye Institute | Rapid City | South Dakota | 57701 | — |
| Southeastern Retina Associates | Knoxville | Tennessee | 37922 | — |
| Tennessee Retina | Nashville | Tennessee | 37203 | — |
| Texas Retina Associates | Arlington | Texas | 76012 | — |
| Retina Foundation of the Southwest | Dallas | Texas | 75231 | — |
| Texas Retina Associates-Plano | Dallas | Texas | 75231 | — |
| Retina Consultants of Houston | Houston | Texas | 77030 | — |
| Retina Consultants of Houston | The Woodlands | Texas | 77384 | — |
| Strategic Clinical Research Group, LLC | Willow Park | Texas | 76087 | — |
| University of Virginia | Charlottesville | Virginia | 22903 | — |
| Spokane Eye Clinical Research | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04465955, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 30, 2025 · Synced May 13, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04465955 live on ClinicalTrials.gov.