Phase 2a Evaluation of Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Patients With Primary Sclerosing Cholangitis (PSC)
Public ClinicalTrials.gov record NCT04480840. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Dose-ranging, Placebo-controlled, Phase 2a Evaluation of the Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Participants With Primary Sclerosing Cholangitis (PSC) and Suspected Liver Fibrosis (INTEGRIS-PSC)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A Phase 2a, multicenter, randomized, double-blind, dose-ranging, placebo-controlled, study to evaluate the safety, tolerability, and PK of PLN-74809 in participants with primary sclerosing cholangitis and suspected liver fibrosis
Study identification
- NCT ID
- NCT04480840
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 121 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 27, 2020 (Actual)
- Primary completion
- Feb 26, 2024 (Actual)
- Completion
- Mar 18, 2024 (Actual)
- Last update posted
- Jan 23, 2026
2020 – 2024
United States locations
- U.S. sites
- 21
- U.S. states
- 14
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| California Liver Research Institute | Pasadena | California | 91105 | — |
| Stanford University School of Medicine | Redwood City | California | 94063 | — |
| University of California, Davis Medical Center | Sacramento | California | 95817 | — |
| California Pacific Medical Center Research Institute | San Francisco | California | 94109 | — |
| University of California San Francisco | San Francisco | California | 94143 | — |
| Yale School of Medicine | New Haven | Connecticut | 06511 | — |
| Florida Research Institute | Lakewood Rch | Florida | 34211 | — |
| Schiff Center of Liver Diseases/University of Miami | Miami | Florida | 33136 | — |
| Piedmont Atlanta Hospital | Atlanta | Georgia | 30309 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Indiana University Health University Hospital | Indianapolis | Indiana | 46202 | — |
| Massachusetts General Hospital Gastroenterology Liver Center | Boston | Massachusetts | 02114 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Health System | Novi | Michigan | 48377 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Perelman Center for Advanced Medicine | Philadelphia | Pennsylvania | 19104 | — |
| Vanderbilt Digestive Disease Center | Nashville | Tennessee | 37232 | — |
| Baylor College of Medicine - Advanced Liver Therapies | Houston | Texas | 77030 | — |
| Bon Secours Liver Institute of Hampton Roads | Newport News | Virginia | 23602 | — |
| VCU Health Clinical Research Services Unit | Richmond | Virginia | 23298 | — |
| Liver Institute Northwest | Seattle | Washington | 98105 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 39 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04480840, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 23, 2026 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04480840 live on ClinicalTrials.gov.