A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Public ClinicalTrials.gov record NCT04487080. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib Versus Lazertinib as First-Line Treatment in Patients With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer.
Study identification
- NCT ID
- NCT04487080
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Janssen Research & Development, LLC
- Industry
- Enrollment
- 1,074 participants
Conditions and interventions
Conditions
Interventions
- Amivantamab Drug
- Lazertinib Drug
- Osimertinib Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 29, 2020
- Primary completion
- Aug 10, 2023
- Completion
- Nov 29, 2027
- Last update posted
- May 7, 2026
2020 – 2027
United States locations
- U.S. sites
- 20
- U.S. states
- 16
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Oncology Associates, PC - HAL | Goodyear | Arizona | 85395 | — |
| Yuma Regional Medical Center | Yuma | Arizona | 85364 | — |
| City of Hope Long Beach Elm | Long Beach | California | 90813 | — |
| University of California Irvine | Orange | California | 92868 | — |
| Rocky Mountain Cancer Centers | Lone Tree | Colorado | 80124 | — |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32256 | — |
| University Cancer And Blood Center LLC | Athens | Georgia | 30607 | — |
| East Jefferson General Hospital | Metairie | Louisiana | 70006 | — |
| Maryland Oncology Hematology, PA | Columbia | Maryland | 21044 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Minnesota Oncology Hematology P A | Edina | Minnesota | 55435 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Washington University School Of Medicine | St Louis | Missouri | 63110 | — |
| Astera Cancer Care | East Brunswick | New Jersey | 08816 | — |
| Willamette Valley Cancer Institute and Research Center | Eugene | Oregon | 97401 | — |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15232 | — |
| Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | — |
| Texas Oncology P A | Austin | Texas | 78745 | — |
| Oncology Consultants Texas | Houston | Texas | 77030 | — |
| Virginia Cancer Specialists | Fairfax | Virginia | 22031 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 249 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04487080, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 7, 2026 · Synced May 10, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04487080 live on ClinicalTrials.gov.