I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients
Public ClinicalTrials.gov record NCT04488081. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
I-SPY COVID TRIAL: An Adaptive Platform Trial to Reduce Mortality and Ventilator Requirements for Critically Ill Patients
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this project is to rapidly screen promising agents, in the setting of an adaptive platform trial, for treatment of critically ill COVID-19 patients. In this phase 2 platform design, agents will be identified with a signal suggesting a big impact on reducing mortality and the need for, as well as duration, of mechanical ventilation.
Study identification
- NCT ID
- NCT04488081
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 1,500 participants
Conditions and interventions
Conditions
Interventions
- Remdesivir Drug
- Imatinib Mesylate Drug
- Dexamethasone Drug
- Cenicriviroc Drug
- Icatibant Drug
- Apremilast Drug
- dornase alfa Biological
- Celecoxib Drug
- Famotidine Drug
- IC14 Biological
- Aviptadil Drug
- narsoplimab Biological
- Cyproheptadine Drug
- Cyclosporine Drug
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 31, 2020 (Actual)
- Primary completion
- Jul 31, 2028 (Estimated)
- Completion
- Jul 31, 2030 (Estimated)
- Last update posted
- Mar 16, 2026
2020 – 2030
United States locations
- U.S. sites
- 36
- U.S. states
- 20
- U.S. cities
- 33
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| UC Davis Medical Center | Davis | California | 95817 | — |
| UC Irvine Medical Center | Irvine | California | 92868 | — |
| Long Beach Memorial Medical Center | Long Beach | California | 90806 | — |
| Kaiser LAMC | Los Angeles | California | 90027 | — |
| University of Southern California | Los Angeles | California | 90033 | — |
| Hoag Memorial Hospital Presbyterian | Newport Beach | California | 92663 | — |
| University of California San Francisco (UCSF) | San Francisco | California | 94115 | — |
| University of Colorado | Aurora | Colorado | 80045 | — |
| Yale Cancer Center | New Haven | Connecticut | 06510 | — |
| Stamford Health | Stamford | Connecticut | 06904 | — |
| Georgetown University | Washington D.C. | District of Columbia | 20007 | — |
| University of Miami | Coral Gables | Florida | 33124 | — |
| University of Florida | Gainesville | Florida | 32608 | — |
| Emory University | Atlanta | Georgia | 30322 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Corewell Health | Grand Rapids | Michigan | 49503 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| Kalispell Regional Medical Center | Kalispell | Montana | 59901 | — |
| Logan Health Medical Center | Kalispell | Montana | 59901 | — |
| Virtua Mount Holly Hospital | Mount Holly | New Jersey | 08060 | — |
| Virtua Voorhees Hospital | Voorhees Township | New Jersey | 08043 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Montefiore Medical Center | The Bronx | New York | 10461 | — |
| Wake Forest Baptist Comprehensive Cancer Center | Winston-Salem | North Carolina | 27157 | — |
| University Hospital Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| University of Pennsylvania (U Penn) | Philadelphia | Pennsylvania | 19104 | — |
| Lankenau Medical Center (Mainline Health) | Wynnewood | Pennsylvania | 19096 | — |
| Main Line Health - Lankenau Medical Center | Wynnewood | Pennsylvania | 19096 | — |
| Sanford Health | Souix Falls | South Dakota | 57109 | — |
| DHR Health | Edinburg | Texas | 78539 | — |
| University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| WVU Medicine | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04488081, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 16, 2026 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04488081 live on ClinicalTrials.gov.