A Multicenter, Randomized Study in Participants With Diabetic Retinopathy Without Center-involved Diabetic Macular Edema To Evaluate the Efficacy, Safety, and Pharmacokinetics of Ranibizumab Delivered Via the Port Delivery System Relative to the Comparator Arm
Public ClinicalTrials.gov record NCT04503551. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Multicenter, Randomized Study of the Efficacy, Safety, and Pharmacokinetics of the Port Delivery System With Ranibizumab in Patients With Diabetic Retinopathy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Study GR41675 is a Multicenter, Randomized Study in Participants with Diabetic Retinopathy (DR) Without Center-Involved Diabetic Macular Edema (CI-DME) to Evaluate the Efficacy, Safety of the Port Delivery System with Ranibizumab (PDS) Relative to the Comparator Arm
Study identification
- NCT ID
- NCT04503551
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 174 participants
Conditions and interventions
Conditions
Interventions
- PDS Implant Pre-Filled with 100 mg/mL Ranibizumab Drug
- Intravitreal Ranibizumab 0.5 mg Injection Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 10, 2020 (Actual)
- Primary completion
- Oct 3, 2022 (Actual)
- Completion
- Feb 23, 2026 (Actual)
- Last update posted
- Apr 2, 2026
2020 – 2026
United States locations
- U.S. sites
- 64
- U.S. states
- 28
- U.S. cities
- 62
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Barnet Dulaney Perkins Eye Center | Mesa | Arizona | 85206 | — |
| Retinal Consultants of Arizona;Opthalmology | Phoenix | Arizona | 85014 | — |
| Associated Retina Consultants | Phoenix | Arizona | 85020 | — |
| California Retina Consultants | Bakersfield | California | 93309 | — |
| The Retina Partners | Encino | California | 91436 | — |
| Retina Consultants of Orange County;Clinical Research | Fullerton | California | 92835 | — |
| Jules Stein Eye Institute/ UCLA | Los Angeles | California | 90095 | — |
| California Eye Specialists Medical Group | Pasadena | California | 91107 | — |
| Kaiser Permanente;RESEARCH AND EVALUATION | Riverside | California | 92505 | — |
| Retina Consultants Medical Group | Sacramento | California | 95841 | — |
| Orange County Retina Medical Group | Santa Ana | California | 92705 | — |
| Southwest Retina Research Center | Durango | Colorado | 81303 | — |
| Colorado Clinical Research | Lakewood | Colorado | 80228 | — |
| Retina Group of New England | Waterford | Connecticut | 06385 | — |
| Retina Specialty Institute | Pensacola | Florida | 32503 | — |
| Fort Lauderdale Eye Institute | Plantation | Florida | 33324 | — |
| Retina Associates of Florida;Retina Associates of Florida | Tampa | Florida | 33609 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| Georgia Retina | Marietta | Georgia | 30060 | — |
| Retina Consultants of Hawaii at Pali Momi Medical Center | ‘Aiea | Hawaii | 96701 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| Illinois Retina Associates | Joliet | Illinois | 60435 | — |
| University Retina | Lemont | Illinois | 60439 | — |
| Retina Associates | Lenexa | Kansas | 66215 | — |
| Maine Eye Center | Portland | Maine | 04605 | — |
| The Retina Care Center | Baltimore | Maryland | 21209 | — |
| Johns Hopkins Hospital;Johns Hopkins Med;Wilmer Eye Inst | Baltimore | Maryland | 21287 | — |
| Cumberland Valley Retina Consultants;Clinical Research | Hagerstown | Maryland | 21740 | — |
| Associated Retinal Consultants - Royal Oak | Royal Oak | Michigan | 48073 | — |
| VitreoRetinal Surgery PLLC;DBA Retina Consultants of Minnesota | Minneapolis | Minnesota | 55435 | — |
| Pepose Vision Institute | Chesterfield | Missouri | 63017 | — |
| Sierra Eye Associates | Reno | Nevada | 89502 | — |
| Envision Ocular, LLC | Bloomfield | New Jersey | 07003 | — |
| Retina Associates of New Jersey | Teaneck | New Jersey | 07666 | — |
| Retina Vitreous Surgeons of Central New York | Liverpool | New York | 13088 | — |
| New York University (NYU) | New York | New York | 10012 | — |
| Asheville Eye Associates Western Carolina Retinal Associates;Clinical Research | Asheville | North Carolina | 28803 | — |
| Charlotte Eye Ear Nose and Throat Associates- SouthPark;Retina | Charlotte | North Carolina | 28210 | — |
| Duke Eye Center | Durham | North Carolina | 27705 | — |
| Cape Fear Retinal Associates | Wilmington | North Carolina | 28401 | — |
| Ohio State Havener Eye Institute;Ophthalmology Research | Columbus | Ohio | 43212 | — |
| Retina Vitreous Center - Glen Eagles | Edmond | Oklahoma | 73013 | — |
| Retina Northwest;Research Department | Portland | Oregon | 97221 | — |
| Mid Atlantic Retina;Retina Research | Philadelphia | Pennsylvania | 19107 | — |
| Charleston Neuroscience | Ladson | South Carolina | 29456 | — |
| Palmetto Retina Center | West Columbia | South Carolina | 29169 | — |
| Charles Retina Institution;Retina surgery | Germantown | Tennessee | 38138 | — |
| Southeastern Retina Associates | Knoxville | Tennessee | 37922 | — |
| Tennessee Retina | Nashville | Tennessee | 37203 | — |
| Retina Research Institute of Texas | Abilene | Texas | 79606 | — |
| Austin Retina Associates;Opthalmology | Austin | Texas | 78705 | — |
| Retina & Vitreous of Texas | Bellaire | Texas | 77401 | — |
| Texas Retina Associates;Research | Dallas | Texas | 75231 | — |
| Retina Center of Texas | Grapevine | Texas | 76051 | — |
| Retina Consultants of Texas | Houston | Texas | 77401 | — |
| Medical Center Ophthalmology Associates | San Antonio | Texas | 78240 | — |
| Retina Consultants of Texas | The Woodlands | Texas | 77384 | — |
| Rocky Mountain Retina Consultants | Murray | Utah | 84107 | — |
| Retina Associates of Utah, PLLC;Clinical Research | Salt Lake City | Utah | 84107 | — |
| Piedmont Eye Center | Lynchburg | Virginia | 24502 | — |
| Wagner Kapoor Institute;Opthalmology | Norfolk | Virginia | 23502 | — |
| Retina Institute of Virginia | Richmond | Virginia | 23235 | — |
| Pacific Northwest Retina | Silverdale | Washington | 98383 | — |
| Spokane Eye Clinical Research;Spokane Eye Surgery Center | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04503551, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 2, 2026 · Synced Oct 28, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04503551 live on ClinicalTrials.gov.