EMPACT-MI: A Study to Test Whether Empagliflozin Can Lower the Risk of Heart Failure and Death in People Who Had a Heart Attack (Myocardial Infarction)
Public ClinicalTrials.gov record NCT04509674. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
EMPACT-MI: A Streamlined, Multicentre, Randomised, Parallel Group, Double-blind Placebo-controlled Superiority Trial to Evaluate the Effect of EMPAgliflozin on Hospitalisation for Heart Failure and Mortality in Patients With aCuTe Myocardial Infarction
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a study in adults who had a heart attack (myocardial infarction). The purpose of this study is to find out whether a medicine called empagliflozin helps to lower the chances of having to go to the hospital for heart failure and whether it lowers the chances of dying from cardiovascular disease. People who are in hospital may join the study soon after being treated for their heart attack. Participants are put into 2 groups by chance. One group takes 1 empagliflozin tablet a day. The other group takes 1 placebo tablet a day. Placebo tablets look like empagliflozin tablets but do not contain any medicine. All participants continue their standard treatment. Empagliflozin belongs to a class of medicines known as SGLT-2 inhibitors. Empagliflozin is a medicine that helps people with type 2 diabetes to lower their blood sugar. Researchers think that empagliflozin might also help people after heart attack who are at risk for heart failure, whether or not they have diabetes. Participants are in the study for about 1 to 2 years. During this time, there are about 4 visits inperson, 2 visits are done either by phone or by use of an mobile application. Results between the empagliflozin and placebo groups are compared. The doctors also regularly check the general health of the participants.
Study identification
- NCT ID
- NCT04509674
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 6,522 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 16, 2020 (Actual)
- Primary completion
- Nov 5, 2023 (Actual)
- Completion
- Nov 5, 2023 (Actual)
- Last update posted
- Jan 7, 2025
2020 – 2023
United States locations
- U.S. sites
- 85
- U.S. states
- 29
- U.S. cities
- 78
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Advanced Cardiovascular LLC | Alexander City | Alabama | 35010 | — |
| Grandview Medical Center | Birmingham | Alabama | 35243 | — |
| Heart Center Research, LLC | Huntsville | Alabama | 35801 | — |
| Mercy Gilbert Medical Center | Gilbert | Arizona | 85297 | — |
| Arkansas Cardiology, PA | Little Rock | Arkansas | 72205 | — |
| Comprehensive Cardiovascular Medical Group | Bakersfield | California | 93309 | — |
| Valley Clinical Trials, Inc. | Covina | California | 91723 | — |
| Cardiovascular Innovation and Research Center | Long Beach | California | 90813 | — |
| University of California Los Angeles | Los Angeles | California | 90095 | — |
| InvivoCure | Mission Hills | California | 91346 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Valley Clinical Trials, Inc. | Pasadena | California | 91105 | — |
| Kaiser Permanente | San Diego | California | 92123 | — |
| San Diego Cardiac Center | San Diego | California | 92123 | — |
| The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Torrance | California | 90502 | — |
| Interventional Cardiology Medical Group | West Hills | California | 91307 | — |
| George Washington University Medical Faculty Associates | Washington D.C. | District of Columbia | 20037 | — |
| Clearwater Cardiovascular Consultants | Clearwater | Florida | 33756 | — |
| Integrative Research Associates | Fort Lauderdale | Florida | 33312 | — |
| University of Florida Health Jacksonville | Jacksonville | Florida | 32209 | — |
| Cardiology Partners Clinical Research Institute | Palm Beach Gardens | Florida | 33410 | — |
| Charlotte Heart Group Research Center | Port Charlotte | Florida | 33952 | — |
| Grady Memorial Hospital | Atlanta | Georgia | 30303 | — |
| Cardiovascular Consultants of South Georgia, LLC | Thomasville | Georgia | 31792 | — |
| Atlanta Heart Specialists, LLC | Tucker | Georgia | 30084 | — |
| Advanced Heart Care, LLC, Medicoricum, LLC | Fairview Heights | Illinois | 62208 | — |
| Midwest Cardiovascular Research and Education Foundation | Elkhart | Indiana | 46514 | — |
| Cardiovascular Research of Northwest Indiana, LLC | Munster | Indiana | 46321 | — |
| Reid Physician Associates | Richmond | Indiana | 47374 | — |
| Midwest Heart and Vascular Specialists | Overland Park | Kansas | 66211 | — |
| University of Kentucky Medical Center | Lexington | Kentucky | 40536-0200 | — |
| University of Louisville | Louisville | Kentucky | 40202 | — |
| Eastern Maine Medical Center | Bangor | Maine | 04401 | — |
| Cardiovascular Specialists of Central Maryland | Columbia | Maryland | 21044 | — |
| Shady Grove Adventist Hospital | Rockville | Maryland | 20850 | — |
| Healthy Heart Cardiology | Grand Rapids | Michigan | 49546 | — |
| Western Michigan University | Kalamazoo | Michigan | 49009 | — |
| Mid Michigan Medical Center | Midland | Michigan | 48670 | — |
| Michigan Heart, PC | Ypsilanti | Michigan | 48197 | — |
| Minneapolis Heart Institute Foundation | Minneapolis | Minnesota | 55407 | — |
| Cardiology Associates Research, LLC | Tupelo | Mississippi | 38801 | — |
| Missouri Cardiovascular Specialists, LLP | Columbia | Missouri | 65201 | — |
| University of Missouri Health System | Columbia | Missouri | 65212 | — |
| North Kansas City Hospital | North Kansas City | Missouri | 64116 | — |
| Gateway Cardiology, PC | St Louis | Missouri | 63128 | — |
| St. Louis Heart and Vascular, P.C. | St Louis | Missouri | 63136 | — |
| Holy Name Medical Center | Hackensack | New Jersey | 07601 | — |
| AtlantiCare | Pomona | New Jersey | 08240 | — |
| The Heart House | Vineland | New Jersey | 08360 | — |
| SJH Cardiology Associates | Liverpool | New York | 13088 | — |
| Stony Brook University Hospital | Stony Brook | New York | 11794 | — |
| Asheville Cardiology Associates | Asheville | North Carolina | 28803 | — |
| The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27517 | — |
| Duke University Medical Center | Durham | North Carolina | 27705 | — |
| Moses H. Cone Memorial Hospital | Greensboro | North Carolina | 27401 | — |
| Medication Management, LLC | Greensboro | North Carolina | 27405 | — |
| North Carolina Heart and Vascular | Raleigh | North Carolina | 27607 | — |
| Trinity Health Center Medical Arts | Minot | North Dakota | 58701 | — |
| Aultman Hospital | Canton | Ohio | 44710 | — |
| Cincinnati VA Medical Center | Cincinnati | Ohio | 45220 | — |
| Kettering Medical Center | Kettering | Ohio | 45429 | — |
| Oklahoma Heart Hospital Research Foundation, Incorporated | Oklahoma City | Oklahoma | 73120 | — |
| South Oklahoma Heart Research Group | Oklahoma City | Oklahoma | 73135 | — |
| Capital Area Research, LLC | Camp Hill | Pennsylvania | 17011 | — |
| Penn Presbyterian Medical Center | Philadelphia | Pennsylvania | 19104 | — |
| Guthrie Medical Group PC | Sayre | Pennsylvania | 18840 | — |
| Upstate Cardiology, PA | Greenville | South Carolina | 29607 | — |
| Carolina Heart Specialists, LLC | Lancaster | South Carolina | 29720 | — |
| Monument Health | Rapid City | South Dakota | 57701 | — |
| Centennial Heart Cardiovascular Consultants, LLC | Nashville | Tennessee | 37203 | — |
| Parkway Cardiology Associates | Oak Ridge | Tennessee | 37830 | — |
| Cardiovascular Research of Knoxville | Powell | Tennessee | 37849 | — |
| Texas Health Presbyterian Hospital Allen | Allen | Texas | 75013 | — |
| Amarillo Heart Clinical Research Institute, Incorporated | Amarillo | Texas | 79106 | — |
| Pharmatex Research | Amarillo | Texas | 79109 | — |
| Dallas VA Medical Center | Dallas | Texas | 75216 | — |
| Baylor Scott and White Health | Plano | Texas | 75093 | — |
| South Texas Cardiovascular Consultants | San Antonio | Texas | 78201 | — |
| Revival Research Institute, LLC. | Sherman | Texas | 75092 | — |
| Cardiovascular Associates of East Texas, PA | Tyler | Texas | 75701 | — |
| Carient Heart and Vascular | Manassas | Virginia | 20109 | — |
| Riverside Regional Medical Center | Newport News | Virginia | 23601 | — |
| Tidewater Physicians Multispecialty Group | Newport News | Virginia | 23606 | — |
| Sentara Hospitals | Norfolk | Virginia | 23507 | — |
| Roanoke Heart Institute PLC | Roanoke | Virginia | 24014 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 354 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04509674, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 7, 2025 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04509674 live on ClinicalTrials.gov.