RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Neovascular Age-Related Macular Degeneration (nAMD)
Public ClinicalTrials.gov record NCT04514653. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Dose-escalation, Ranibizumab-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of RGX-314 Gene Therapy Delivered Via One or Two Suprachoroidal Space (SCS) Injections in Participants With Neovascular Age-Related Macular Degeneration (nAMD) (AAVIATE)
Study identification
- NCT ID
- NCT04514653
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- AbbVie
- Industry
- Enrollment
- 146 participants
Conditions and interventions
Interventions
- ABBV-RGX-314 Dose 1 Genetic
- ABBV-RGX-314 Dose 2 Genetic
- ABBV-RGX-314 Dose 3 Genetic
- ABBV-RGX-314 Dose 4 Genetic
- Local Steroid Drug
- Ranibizumab Biological
- Topical Steroid Drug
Genetic · Drug · Biological
Eligibility (public fields only)
- Age range
- 50 Years to 89 Years
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 24, 2020
- Primary completion
- Jul 31, 2026
- Completion
- Jan 31, 2027
- Last update posted
- Feb 26, 2026
2020 – 2027
United States locations
- U.S. sites
- 18
- U.S. states
- 12
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retinal Research Institute /ID# 255925 | Phoenix | Arizona | 85053 | — |
| California Retina Consultants - Bakersfield /ID# 255910 | Bakersfield | California | 93309-1677 | — |
| Retina Vitreous Assoc Med Grp /ID# 255921 | Beverly Hills | California | 90211 | — |
| Retinal Diagnostic Center /ID# 272275 | Campbell | California | 95008 | — |
| Northern California Retina Vitreous Associates Medical Group, Inc /ID# 255920 | Mountain View | California | 94040-4101 | — |
| Retina Consultants of San Diego /ID# 255911 | Poway | California | 92064-2530 | — |
| California Retina Consultants - Santa Barbara /ID# 255923 | Santa Barbara | California | 93103 | — |
| Southeast Retina Center /ID# 255912 | Augusta | Georgia | 30909 | — |
| Springfield Clinic - First /ID# 272274 | Springfield | Illinois | 62702 | — |
| Johns Hopkins Hospital /ID# 255919 | Baltimore | Maryland | 21287 | — |
| Ophthalmic Consultants of Boston /ID# 255917 | Boston | Massachusetts | 02114 | — |
| Sierra Eye Associates /ID# 255908 | Reno | Nevada | 89502 | — |
| Eye Associates of New Mexico /ID# 255915 | Albuquerque | New Mexico | 87109 | — |
| Duke University Medical Center /ID# 267646 | Durham | North Carolina | 27710 | — |
| Mid Atlantic Retina /ID# 255906 | Philadelphia | Pennsylvania | 19107 | — |
| Charles Retina Institute /ID# 255922 | Germantown | Tennessee | 38138 | — |
| Tennessee Retina - Nashville /ID# 255918 | Nashville | Tennessee | 37203-1513 | — |
| Retina Consultants - The Woodlands /ID# 255924 | The Woodlands | Texas | 77384 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04514653, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 26, 2026 · Synced Apr 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04514653 live on ClinicalTrials.gov.