Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
Public ClinicalTrials.gov record NCT04541082. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A First-in-human Phase I Single-agent Dose-escalation, Food Effect and Dose Expansion Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
Study identification
- NCT ID
- NCT04541082
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Lead sponsor
- Jazz Pharmaceuticals
- Industry
- Enrollment
- 102 participants
Conditions and interventions
Conditions
- Anaplastic Astrocytoma
- Anaplastic Meningioma
- Anaplastic Oligodendroglioma
- Anaplastic Pleomorphic Xanthoastrocytoma
- Atypical Meningioma
- Central Nervous System Neoplasms
- Choroid Plexus Neoplasms
- Diffuse Astrocytoma
- Diffuse Midline Glioma, H3 K27M-Mutant
- Ependymoma
- Ependymoma, Anaplastic
- Glial Tumor
- Glioblastoma
- Gliomatosis Cerebri
- Gliosarcoma, Adult
- Medulloblastoma
- Neuroectodermal Tumors
- Neuroectodermal Tumors, Primitive
- Oligodendroglioma
- Pilocytic Astrocytoma
- Pineal Tumor
- Pleomorphic Xanthoastrocytoma
- Teratoid Rhabdoid Tumor
Interventions
- ONC206 Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 25, 2020
- Primary completion
- Jun 30, 2026
- Completion
- Nov 30, 2026
- Last update posted
- Dec 17, 2025
2020 – 2026
United States locations
- U.S. sites
- 1
- U.S. states
- 1
- U.S. cities
- 1
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| National Institutes of Health | Bethesda | Maryland | 20892 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04541082, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 17, 2025 · Synced May 19, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04541082 live on ClinicalTrials.gov.