Study to Explore the Efficacy and Safety of BIO89-100 (Pegozafermin) in Participants With Severe Hypertriglyceridemia
Public ClinicalTrials.gov record NCT04541186. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Explore the Efficacy and Safety of BIO89-100 in Subjects With Severe Hypertriglyceridemia
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is designed to assess the efficacy, safety, and tolerability of different doses and dose regimens (once weekly \[QW\] or every 2 weeks \[Q2W\]), subcutaneous (SC) dosing of BIO89-100 (pegozafermin) compared to placebo in participants with severe hypertriglyceridemia (SHTG).
Study identification
- NCT ID
- NCT04541186
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 86 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 21 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 1, 2020 (Actual)
- Primary completion
- May 19, 2022 (Actual)
- Completion
- May 31, 2022 (Actual)
- Last update posted
- Jul 25, 2024
2020 – 2022
United States locations
- U.S. sites
- 32
- U.S. states
- 14
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| 89Bio Clinical Study Site | La Mesa | California | 91942 | — |
| 89Bio Clinical Study Site | San Francisco | California | 94158 | — |
| 89Bio Clinical Study Site | Clearwater | Florida | 33756 | — |
| 89Bio Clinical Study Site | Greenacres City | Florida | 33467 | — |
| 89Bio Clinical Study Site | Jacksonville | Florida | 32205 | — |
| 89Bio Clinical Study Site | Miami | Florida | 33125 | — |
| 89Bio Clinical Study Site | Miami | Florida | 33135 | — |
| 89Bio Clinical Study Site | Miami Lakes | Florida | 33014 | — |
| 89Bio Clinical Study Site | Miami Lakes | Florida | 33016 | — |
| 89Bio Clinical Study Site | North Miami Beach | Florida | 33162 | — |
| 89Bio Clinical Study Site | Orlando | Florida | 32825 | — |
| 89Bio Clinical Study Site | Tampa | Florida | 33606 | — |
| 89Bio Clinical Study Site | Lawrenceville | Georgia | 30044 | — |
| 89Bio Clinical Study Site | Quincy | Illinois | 62301 | — |
| 89Bio Clinical Study Site | Wauconda | Illinois | 60084 | — |
| 89Bio Clinical Study Site | West Des Moines | Iowa | 50266 | — |
| 89Bio Clinical Study Site | Louisville | Kentucky | 40213 | — |
| 89Bio Clinical Study Site | Olive Branch | Mississippi | 38654 | — |
| 89Bio Clinical Study Site | Albany | New York | 12203 | — |
| 89Bio Clinical Study Site | Greensboro | North Carolina | 27408 | — |
| 89Bio Clinical Study Site | Morganton | North Carolina | 28655 | — |
| 89Bio Clinical Study Site | Marion | Ohio | 43303 | — |
| 89Bio Clinical Study Site | Summerville | South Carolina | 29435 | — |
| 89Bio Clinical Study Site | Chattanooga | Tennessee | 37421 | — |
| 89Bio Clinical Study Site | Kingsport | Tennessee | 37660 | — |
| 89Bio Clinical Study Site | Austin | Texas | 78705 | — |
| 89Bio Clinical Study Site | Dallas | Texas | 75204 | — |
| 89Bio Clinical Study Site | Dallas | Texas | 77365 | — |
| 89Bio Clinical Study Site | Houston | Texas | 77089 | — |
| 89Bio Clinical Study Site | Lampasas | Texas | 76550 | — |
| 89Bio Clinical Study Site | Magnolia | Texas | 77355 | — |
| 89Bio Clinical Study Site | Manassas | Virginia | 20110 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 16 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04541186, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 25, 2024 · Synced Oct 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04541186 live on ClinicalTrials.gov.